Search results for "N-3"
showing 10 items of 365 documents
Rôle du récepteur nucléaire d'activation et de prolifération des péroxysomes (PPAR-alpha) dans la modulation de l'inflammation et l'activation des ce…
2010
We assessed, in this study, the effects of PPARα deficiency on the expression of mRNAencoding for insulin gene transcription factors in pancreatic β-cells along with thoseimplicated in inflammation in adipose tissues. On fasting, the adult PPARα-null mice werehypoglycemic. Serum insulin concentrations and its pancreatic mRNA transcripts weredownregulated in PPARα-null mice, suggesting that PPARα gene deletion contributes to lowinsulin gene transcription. The PPARα gene deletion downregulates the mRNA expression ofinsulin gene transcription factors, i.e., Pdx-1, Nkx6.1 and MafA. Besides, the pancreaticfunction was diminished by PPARα deficiency as PPARα-null mice expressed low pancreaticGlut…
1-methil-3H-pyrazolo[1-2-a]benzo[1-2-3-4]tetrazin-3-ones, design synthesis and biological activity of new antitumoral agents
2005
1-Methylpyrazolo[1,2-a]benzo[1,2,3,4]tetrazin-3-ones 4, synthesized in good to excellent yields, were designed as novel alkylating agents because of their peculiar chemical behavior. All derivatives showed antiproliferative activity against more than 50 types of tumor cell lines with GI50 reaching sub-micromolar values. SAR studies revealed that the presence of a chlorine atom is well-tolerated in both positions 8 and 9, whereas in the case of the methyl group, switching from the 8 to the 9 position gives rise to the most active compound of the series, 4g, either for the number of cell lines inhibited and for selectivity against leukaemia and renal cancer subpanels. COMPARE and 3D-MIND comp…
The CD38-Positive and CD38-Negative Subsets of CD34(high)-Positive Primary Acute Myeloid Leukemia Blasts Differ Considerably in the Expression of Imm…
2008
Abstract Acute myeloid leukemia (AML) is thought to arise from a rare putative ‘leukemic stem cell’ that is capable of self-renewal and formation of leukemic blasts. Serial xenotransplantation studies in immunodeficient mice have shown that this leukemia-initiating cell resides at very low numbers within CD34(high)-positive CD38-negative AML cells. Thus, immunotherapeutic approaches successfully eradicating this cell compartment should result in cure from disease. The objective of our study was to characterize the immune phenotype of the CD38-negative and CD38-positive subsets of primary CD34(high)-positive AML blasts ex vivo. We obtained therapeutic leukapheresis products from 17 AML patie…
CCDC 864207: Experimental Crystal Structure Determination
2012
Related Article: R.W.Troff, R.Hovorka, T.Weilandt, A.Lutzen, M.Cetina, M.Nieger, D.Lentz, K.Rissanen, C.A.Schalley|2012|Dalton Trans.|41|8410|doi:10.1039/c2dt30190c
CCDC 996515: Experimental Crystal Structure Determination
2014
Related Article: Susana Ibañez, Larisa Oresmaa, Francisco Estevan, Pipsa Hirva, Mercedes Sanaú, Ma Angeles Úbeda|2014|Organometallics|33|5378|doi:10.1021/om500702j
Effects of n-3 Polyunsaturated Fatty Acids (ω-3) Supplementation on Some Cardiovascular Risk Factors with a Ketogenic Mediterranean Diet
2015
Background: the ketogenic diet (KD) has become a widely used nutritional approach for weight loss. Some of the KD’s positive effects on metabolism and cardiovascular risk factors are similar to those seen after n-3 polyunsaturated fatty acids (ω-3) supplementation. We hypothesized that a ketogenic Mediterranean diet with phytoextracts combined with ω-3 supplementation may have increased positive effects on cardiovascular risk factors and inflammation. Methods: We analyzed 34 male overweight subjects
CCDC 1823433: Experimental Crystal Structure Determination
2018
Related Article: Rajendhraprasad Tatikonda, Evgeny Bulatov, Zülal Özdemir, Nonappa, Matti Haukka|2019|Soft Matter|15|442|doi:10.1039/C8SM02006J
CCDC 1545350: Experimental Crystal Structure Determination
2017
Related Article: Rajendhraprasad Tatikonda, Evgeny Bulatov, Elina Kalenius, Matti Haukka|2017|Cryst.Growth Des.|17|5918|doi:10.1021/acs.cgd.7b01034
CCDC 1477302: Experimental Crystal Structure Determination
2016
Related Article: C. Köhler, E. Rentschler|2016|Dalton Trans.|45|12854|doi:10.1039/C6DT02023B
CCDC 993408: Experimental Crystal Structure Determination
2015
Related Article: Anna Świtlicka-Olszewska, Joanna Palion-Gazda, Tomasz Klemens, Barbara Machura, Julia Vallejo, Joan Cano, Francesc Lloret, Miguel Julve|2016|Dalton Trans.|45|10181|doi:10.1039/C6DT01160H