Search results for "N-3"
showing 10 items of 365 documents
CCDC 1846986: Experimental Crystal Structure Determination
2018
Related Article: Sebastian Lips, Dieter Schollmeyer, Robert Franke, Siegfried R. Waldvogel|2018|Angew.Chem.,Int.Ed.|57|13325|doi:10.1002/anie.201808555
CCDC 1044956: Experimental Crystal Structure Determination
2015
Related Article: Tiia-Riikka Tero, Kirsi Salorinne, Sami Malola, Hannu Häkkinen, Maija Nissinen|2015|CrystEngComm|17|8231|doi:10.1039/C5CE01144B
CCDC 1571124: Experimental Crystal Structure Determination
2017
Related Article: Toms Rekis, Agris Be¯rzinš, Inese Sarcevica, Artis Kons, Ma¯rtinš Balodis, Lia¯na Orola, Heike Lorenz, Andris Actinš|2018|Cryst.Growth Des.|18|264|doi:10.1021/acs.cgd.7b01203
CCDC 1402129: Experimental Crystal Structure Determination
2016
Related Article: Carla Queirós, Andreia Leite, Maria G. M. Couto, mLuís Cunha-Silva, Giampaolo Barone, Baltazar de Castro, Maria Rangel, André M. N. Silva, Ana M. G. Silva|2015|Chem.-Eur.J.|21|15692|doi:10.1002/chem.201502093
9-benzil-9-azabiciklo[3.3.1]nonan-3-ona sintēze
2016
9-benzil-9-azabiciklo[3.3.1]nonān-3-ona sintēze. Mertsa K., zinātniskais vadītājs Dr.Chem. Kļimenkovs I. Bakalaura darbs, 37 lappuses, 5 attēli, 1 tabula, 22 literatūras avoti, 8 pielikumi. Latviešu valodā. Darbā tika izpētītas un salīdzinātas dažādas 9-benzil-9-azabiciklo[3.3.1]nonān-3-ona sintēzes metodes, no kurām tika izvēlētas dažas, kas teorētiski ir izdevīgākas. Eksperimentālajā daļā tika atkārtotas sintēzes pēc publikāciju aprakstiem, kā arī daļēji mainīti reakciju apstākļi. Pēc iegūtajiem rezultātiem tika analizēta dažādu reakcijas apstākļu ietekme uz reakcijas gaitu, izvirzot pieņēmumus, kuri no tiem ir labāk piemēroti. Rezultātu izvērtējumā tika izvirzīti priekšlikumi, kā uzlabot…
Notch‐1 signaling activation sustains overexpression of interleukin 33 in the epithelium of nasal polyps
2019
Abstract BACKGROUND: Alterations in the nasal epithelial barrier homeostasis and increased interleukin 33 (IL-33) expression contribute to the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). AIMS: As Notch-1 signaling is crucial in repair processes of mucosa, the current study assessed Notch-1/Jagged-1 signaling and IL-33 in the epithelium of nasal polyps biopsies from allergic (A-CRSwNP; n = 9) and not allergic (NA-CRSwNP; n = 9) subjects by immunohistochemistry. We also assessed, in a model of nasal epithelial cells, the effects of stimulation of Notch-1 with Jagged-1 on the expression of IL-33 (by flow cytometry, immunofluorescence, and immunocytochemistry), Jagged-1 (…
Interleukin 3 in the treatment of chemotherapy induced thrombocytopenia.
1998
We enrolled 19 cancer patients (11 females, 8 males) with thrombocytopenia after standard dose of chemotherapy to receive IL3 10 mg/kg/day s.c. until hematologic recovery. Therapeutic success was obtained in 69.6% of cycles; a major response in 39.3% and a minor response in 30.3% of cycles. We obtained the best results in case of platelet count <49,000/mm3. The main toxicity was a flu-like syndrome. In two cycles (6%) we registered allergic episodes with flushing and lipothymia. In the 47% of cycles evaluable for toxicity no side effect was registered.
IL-34 is overexpressed in the inflamed salivary glands of patients with Sjogren's syndrome and is associated with the local expansion of pro-inflamma…
2013
Objectives To investigate the expression of IL-34 in labial salivary glands (LSGs) of patients with primary SS (p-SS) and its role in inducing a pro-inflammatory monocyte phenotype. Methods LSG biopsies were obtained from 20 patients with p-SS and 10 patients with non-Sjogren's sicca syndrome (n-SS). The expression of IL-34, IL-1β, TNF-α, IL-17 and IL-23 was assessed by real-time PCR. IL-34 expression was also investigated in LSGs by immunohistochemistry. The frequencies of subpopulations of CD14(+) monocytes were evaluated by flow cytometry among isolated mononuclear cells from peripheral blood and salivary glands from both patients and controls. The role of recombinant IL-34 on isolated p…
Establishing the upper reference limit of Galectin-3 in healthy blood donors
2017
Introduction Galectin-3 (Gal-3) is an independent predictor of poor outcomes and mortality in patients with heart failure (HF). Thus, it has been proposed as a reliable prognostic biomarker for HF. The definition of reference intervals is mandatory for interpreting the findings of experimental studies and encouraging the routine use of biomarkers in clinical practice. To date, no study assessed the reference intervals of Gal-3 and identified the biological variables that affect its concentration in a well-defined healthy population. The aim of this study was to determine the upper reference limit (URL) of Gal-3 in a highly reliable population of healthy subjects. Materials and methods We re…
Effect of interleukin-3 pretreatment on granulocyte/macrophage colony-stimulating factor induced mobilization of circulating haemopoietic progenitor …
1995
Recombinant human colony stimulating factors (CSFs) as single agents are increasingly used for mobilizing peripheral blood progenitor cells (PBPCs) for stem cell transplantation. We have shown in rhesus monkeys that interleukin-3 (IL-3) pretreatment markedly potentiated the increase in PBPC numbers of subsequent administration of granulocyte/macrophage-CSF (GM-CSF). Here we studied the effect of IL-3 pretreatment on GM-CSF-induced mobilization of PB progenitors in patients who were potential candidates for autologous stem cell transplantation (n = 16). Patients were treated with GM-CSF at a dose of 5 micrograms/kg/d for 5 d and after a treatment free interval received another cycle of GM-CS…