Search results for "N2"

PEST-domain-enriched tyrosine phosphatase and glucocorticoids as regulators of anaphylaxis in mice

2011

To cite this article: Obiri DD, Flink N, Maier JV, Neeb A, Maddalo D, Thiele W, Menon A, Stassen M, Kulkarni RA, Garabedian MJ, Barrios AM, Cato ACB. PEST-domain-enriched tyrosine phosphatase and glucocorticoids as regulators of anaphylaxis in mice. Allergy 2012; 67: 175–182. Abstract Background:  PEST-domain-enriched tyrosine phosphatase (PEP) is a protein tyrosine phosphatase exclusively expressed in hematopoietic cells. It is a potent negative regulator of T-cell receptor signalling that acts on receptor-coupled protein tyrosine kinases. PEST-domain-enriched tyrosine phosphatase is also expressed in mast cell and is positively regulated by glucocorticoids, but its function is unknown. In…

Denitrification

2011

Descripción y comparación del perfil de expresión del sistema LIN28/Let-7 y microRNAs asociados en tejido placentario sano y tejido placentario proce…

2017

INTRODUCCIÓN El embarazo ectópico (EE) es una complicación precoz de la gestación en la cual un óvulo fecundado se implanta en un sitio distinto al endometrio de la cavidad uterina. siendo el lugar más frecuente la trompa de Falopio (95-98%). Su incidencia resulta variable en la literatura médica, oscilando entre el 0,6 y el 2% de los embarazos documentados, presentándose con picos más altos en la adolescencia. Este continúa siendo la principal causa de muerte materna en las primeras etapas de la gestación (4-10% de las muertes relacionadas con el embarazo en países desarrollados) y una de las urgencias quirúrgicas más frecuentes del primer trimestre. El EE no es solo una causa importante d…

Synthesis of self-assembled mesoporous 3D In2O3 hierarchical micro flowers composed of nanosheets and their electrochemical properties

2018

This report describes the methodology for the fabrication of mesoporous In2O3 microflowers by hydrothermal and calcination procedures in which In(OH)3/In2S3 acts as an intermediate. Both In2O3 and its precursor were analyzed with scanning electron microscopy, energy dispersive X-ray spectrophotometry, transmission electron microscopy and powder X-ray diffraction. BET surface area, pore size and pore volume analyses were also carried out. Electron microscopy images clearly evidence the self-assembly of 2D nanosheets into the micro flower structure. The mechanism of self-assembly and calcination is reported. Electrochemical properties of the synthesized In2O3 micro flowers were studied. peerR…

2019

Charcot–Marie tooth disease is a hereditary polyneuropathy caused by mutations in Mitofusin-2 (MFN2), a GTPase in the outer mitochondrial membrane involved in the regulation of mitochondrial fusion and bioenergetics. Autosomal-dominant inheritance of a R94Q mutation in MFN2 causes the axonal subtype 2A2A which is characterized by early onset and progressive atrophy of distal muscles caused by motoneuronal degeneration. Here, we studied mitochondrial shape, respiration, cytosolic, and mitochondrial ATP content as well as mitochondrial quality control in MFN2-deficient fibroblasts stably expressing wildtype or R94Q MFN2. Under normal culture conditions, R94Q cells had slightly more fragmented…

Brain Source Correlates of Speech Perception and Reading Processes in Children With and Without Reading Difficulties

2022

Neural correlates in reading and speech processing have been addressed extensively in the literature. While reading skills and speech perception have been shown to be associated with each other, their relationship remains debatable. In this study, we investigated reading skills, speech perception, reading, and their correlates with brain source activity in auditory and visual modalities. We used high-density event-related potentials (ERPs), fixation-related potentials (FRPs), and the source reconstruction method. The analysis was conducted on 12–13-year-old schoolchildren who had different reading levels. Brain ERP source indices were computed from frequently repeated Finnish speech stimuli…

Can differences in microbial abundances help explain enhanced N2O emissions in a permanent grassland under elevated atmospheric CO2?

2011

Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging

2013

Recent genome-wide association studies have linked type-2 diabetes mellitus to a genomic region in chromosome 9p21 near the Ink4/Arf locus, which encodes tumor suppressors that are up-regulated in a variety of mammalian organs during aging. However, it is unclear whether the susceptibility to type-2 diabetes is associated with altered expression of the Ink4/Arf locus. In the present study, we investigated the role of Ink4/Arf in age-dependent alterations of insulin and glucose homeostasis using Super-Ink4/Arf mice which bear an extra copy of the entire Ink4/Arf locus. We find that, in contrast to age-matched wild-type controls, Super-Ink4/Arf mice do not develop glucose intolerance with agi…

Genetic profile and immunohistochemical study of clear cell renal carcinoma: Pathological-anatomical correlation and prognosis.

2021

Abstract Introduction Renal cell carcinoma (RCC) accounts for 2–3% of all tumors being the most frequent solid lesion in the kidney. Objective To determine what genetic alterations and immunohistochemical (IHC) of clear cell renal carcinoma (ccRCC) are associated with prognosis and tumor aggressiveness. Patients and Methods Experimental analytical study with 57 patients who underwent radical and partial nephrectomy between 2005 and 2011, all with diagnosis of ccRCC and minimum post-operative follow-up of 36 months. The pathological study included IHC determination of biomarkers associated (CAIX, CAM 5.2, CD10, c-erbB-2, EGFR, HIF-1a, Ki67, MDM2, PAX-2 y 8, p53, survivin and VEGFR 1 and 2). …

Interlinkages between operational conditions and direct and indirect greenhouse gas emissions in a moving bed membrane biofilm reactor

2016

Nitrous oxide (N2O) can be emitted during wastewater treatment contributing to the global warming due to its high global warming potential,. During the last ten years, several efforts have been provided to improve knowledge on: key mechanisms, operating factors and influent features affecting the N2O production/emission. However, the knowledge on the investigated issues is not completely mature. Indeed, in terms of mathematical modelling, literature shows that a reliable model has not yet been established due to the huge data set required and the complexity of the mechanistic models indicated as the most accurate. In this work, the first attempt to perform a multiregression analysis is pres…