Search results for "NAC"
showing 10 items of 4556 documents
The release of choline from phospholipids mediated by beta-adrenoceptor activation in isolated hearts.
1986
The resting efflux of choline into the perfusate (Tyrode's solution) of isolated hearts was equal to the rate, at which choline was liberated from phospholipid degradation (Lindmar et al. 1986). Infusion of isoprenaline (2 X 10(-7) mol/l), forskolin (1-3 X 10(-6) mol/l) or 3-isobutyl-1-methylxanthine (IBMX; 3 X 10(-4) mol/l) for 40 min markedly enhanced the efflux of choline. The increase was linear during the experimental period and, in the case of isoprenaline, was blocked by 3 X 10(-7) mol/l atenolol. In the guinea-pig heart, IBMX at a threshold concentration of 10(-4) mol/l shifted the concentration-response curve for the effect of forskolin on the efflux of choline to the left by one l…
Participatory Ergonomics: A Model for the Prevention of Occupational Musculoskeletal Disorders
2009
La ergonomía participativa es una estrategia de intervención sobre los riesgos por carga física en los lugares de trabajo escasamente conocida en España, aunque en otros países se cuenta con numerosas experiencias y evidencias en este campo. Son varias las razones que justifican su interés. En primer lugar, aborda una de las categorías de riesgos laborales que mayor impacto tiene sobre la salud de los trabajadores en la mayoría de países, tanto en términos de incidencia, como de prevalencia o incapacidad. En segundo lugar, el principio básico de la ergonomía participativa es la capacitación de los trabajadores para que participen tanto en la identificación de los riesgos y daños a la salud …
Safety of Topical Non-steroidal Anti-Inflammatory Drugs in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis
2019
Objective We aimed to assess the safety of topical non-steroidal anti-inflammatory drugs (NSAIDs) in the management of osteoarthritis (OA) in a systematic review and meta-analysis of randomized, placebo-controlled trials. Methods A comprehensive literature search was undertaken in the MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), and Scopus electronic databases. Randomized, double-blind, placebo-controlled, parallel-group trials that assessed adverse events (AEs) with topical NSAIDs in patients with OA were eligible for inclusion. Authors and/or study sponsors were contacted to obtain the full report of AEs. The primary outcomes were overall severe and serious AEs, as w…
Epidemiological and virological studies into the poliomyelitis in Valencia (1959-1969)
2009
Studies into the polio virus began in Valencia in 1959 with the work undertaken by the microbiologist Vicente Sanchis-Bayarri Vaillant. After his education at the Rochester University and at the Pasteur Institute, Sanchis-Bayarri Vaillant established a laboratory of cell cultures at the Faculty of Medicine in Valencia, where he developed a new diagnostic technique for the poliomyelitis virus. In addition, epidemiological studies were carried out both prior to and post the 1963 vaccination campaign, which proved that Sabin’s oral vaccine was both effective and safe for use.
Trasplante de córnea: aspectos bioéticos
2019
Resumen: Este trabajo aborda los aspectos bioéticos del trasplante de córnea, desde la donación y los tipos de la misma, incluyendo el comercio de órganos y tejidos, así como la metodología del trasplante y el uso de tratamientos inmunosupresores, además del consentimiento informado y la participación del paciente en las decisiones. Se analizan las técnicas actuales, la efectividad y las circunstancias en las que se puede aplicar cada una de ellas así como los estudios emergentes basados en la terapia celular. Algunos de los estudios emplean células troncales derivadas de embriones humanos, y otras de tejidos adultos y células troncales pluripotentes inducidas (iPS). Se propone un análisis …
Comment: Why are females with Fabry disease affected?
2019
Air pollution exposure during pregnancy and childhood autistic traits in four European population-based cohort studies: The ESCAPE Project
2015
Background: Prenatal exposure to air pollutants has been suggested as a possible etiologic factor for the occurrence of autism spectrum disorder. Objectives: We aimed to assess whether prenatal air pollution exposure is associated with childhood autistic traits in the general population. Methods: Ours was a collaborative study of four European population-based birth/child cohorts—CATSS (Sweden), Generation R (the Netherlands), GASPII (Italy), and INMA (Spain). Nitrogen oxides (NO2, NOx) and particulate matter (PM) with diameters of ≤ 2.5 μm (PM2.5), ≤ 10 μm (PM10), and between 2.5 and 10 μm (PMcoarse), and PM2.5 absorbance were estimated for birth addresses by land-use regression models bas…
Kinetic and Kinematic Analysis of Iatrogenic Medial Patellar Instability: Clinical Relevance
2012
We speculate that chronic recurrent soft tissue fatigue or overload due to patellofemoral imbalance could cause anterior knee pain. However, many chondropathies can be asymptomatic due to the biomechanic defence strategies used by the patients. Moreover, we emphasize the importance of the passive restraining structures in patellar stability, in contrast to the role of muscle function advocated by some authors. This could explain why an exercise rehabilitation program could be unsuccessful in improving patellar instability, as it occurred in our cases. Finally, these cases highlight the need for surgeons to be more judicious in their surgical selection for patellofemoral instability and serv…
Factores de rendimiento en el desplazamiento del tenista influenciados por el calzado. (Performance factors on tennis player displacements influenced…
2009
Los desplazamientos laterales son de gran importancia en el tenis. Sin embargo, no ha sido publicado ningun estudio sobre el efecto del calzado sobre el rendimiento en este tipo de movimientos. En el estudio participaron 5 jugadores habituales de tenis y se analizaron 10 calzados comerciales de tenis. El movimiento estudiado consistio en un desplazamiento lateral con parada y cambio de sentido, registrandose las fuerzas mediante una plataforma dinamometrica Dinascan-IBV y grabandose el movimiento con dos camaras de video S-VHS Panasonic WV-BL600. Los resultados de los ANOVAs realizados mostraron que algunas de las variables analizadas eran dependientes del calzado (p < 0.05). De estas, dest…
Canakinumab in systemic juvenile idiopathic arthritis: real-world data from a retrospective Italian cohort
2021
Abstract Objective The objective of this study was to use real-world data to evaluate the effectiveness and safety of canakinumab in Italian patients with systemic JIA (sJIA). Methods A retrospective multicentre study of children with sJIA was performed. Clinical features, laboratory parameters and adverse events were collected at baseline, and 6 and 12 months after starting canakinumab. The primary outcome measure of effectiveness was clinically inactive disease (CID) off glucocorticoids (GCs) treatment at 6 months. Results A total of 80 children from 15 Italian centres were analysed. Of the 12 patients who started canakinumab in CID while receiving anakinra, all maintained CID. Of the 68 …