Search results for "NAD"
showing 10 items of 2033 documents
Four-, five- and six-coordinated Zn-II complexes of OH-containing ligands: Syntheses, structure and reactivity
2002
Four-, five- and six-coordinated complexes of Zn-II with OH-rich molecules possessing an ONO binding core were synthesized, characterized and their structures were established by single-crystal X-ray diffraction, The corresponding metal ion geometries were found to be distorted tetrahedral, square pyramidal and octahedral, respectively. The complexes exhibit interesting lattice structures such as layered and corrugated sheets owing to the presence of a number of weak intermolecular interactions. The five-coordinated, water-bound Zn-II complex was studied because of its putative hydrolysis property towards p-nitrophenyl acetate. (C) Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.
Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (Complex I).
1994
Natural products from the plants of the family Annonaceae, collectively called Annonaceous acetogenins, are very potent inhibitors of the NADH-ubiquinone reductase (Complex I) activity of mammalian mitochondria. The properties of five of such acetogenins are compared with those of rotenone and piericidin, classical potent inhibitors of Complex I. Rolliniastatin-1 and rolliniastatin-2 are more powerful than piericidin in terms of both their inhibitory constant and the protein-dependence of their titre in bovine submitochondrial particles. These acetogenins could be considered therefore the most potent inhibitors of mammalian Complex I. Squamocin and otivarin also have an inhibitory constant …
Bisbenzyltetrahydroisoquinolines, a New Class of Inhibitors of the Mitochondrial Respiratory Chain Complex I
2004
Four bisbenzyltetrahydroisoquinoline alkaloids (-)-medelline, (+)-antioquine, (+)-aromoline, and (+)-obamegine were isolated from the fruits of Xylopia columbiana. These compounds, the previously isolated alkaloids (+)-thaligrisine and (+)-isotetrandrine, as well as their O-acetylated derivatives were assayed on submitochondrial particles from beef heart as inhibitors of the mammalian respiratory chain. The results revealed that these alkaloids act as selective inhibitors of mitochondrial complex I in a 0.15 - 4.71 microM range. O-Acetylation, which increases their lipophilicity, considerably increased the inhibitory potency.
Specific interactions of monotetrahydrofuranic annonaceous acetogenins as inhibitors of mitochondrial complex I.
2000
Annonaceous acetogenins (ACG) are a wide group of cytotoxic compounds isolated from plants of the Annonaceae family. Some of them are promising candidates to be a future new generation of antitumor drugs due to the ability to inhibit the NADH:ubiquinone oxidoreductase of the respiratory chain (mitochondrial complex I), main gate of the energy production in the cell. ACG are currently being tested on standard antitumor trials although little is known about the structure activity relationship at the molecular level. On recent studies, the relevance of several parts of the molecule for the inhibitory potency has been evaluated. Due to the great diversity of skeletons included in this family of…
New intermediates for the synthesis of olefin polymerization catalysts: the complexes [M2(µ-Cl)2Cl4(thf)4](M = Ti or V, thf = tetrahydrofuran); Cryst…
1993
The dimeric titanium(III) and vanadium(III) complexes [M2(µ-Cl)2Cl4(thf)4](M = Ti 1 or V 2, thf = tetrahydrofuran) have been prepared by recrystallization of [MCl3(thf)3] from dichloromethane. In the dimers, composed of slightly distorted edge-sharing octahedra, the metal atoms separated by Ti ⋯ Ti and V ⋯ V distances of 3.711 (3) and 3.619(1)A, respectively, are surrounded by two terminal Cl atoms, two oxygen atoms of thf molecules and are linked by two bridging Cl atoms. The geometry around the titanium atoms differs from that around vanadium because the thf molecules and the terminal chlorine atoms are differently located with respect to the bridging chlorine atoms of the M2(µ-Cl)2 unit.…
FIRST MEASUREMENT OF THE STRANGE QUARK ASYMMETRY AT THE Z(0) PEAK
1995
A measurement of the strange quark forward-backward asymmetry at the Z0 peak was performed using 718,000 multihadronic Z0 decays collected by the DELPHI detector at LEP in 1992. The s-quark was tagged by the presence of high momentum charged kaons identified by the Ring Imaging Cherenkov detector and by Λ0;s decaying into pπ-. The s-quark purity obtained was estimated for the two hadrons to be 43%. The average s-quark asymmetry was found to be 0.131±0.035 (stat.) ±0.013 (syst.). The forward-backward asymmetry was measured for unresolved d-and s-quarks, tagged by the detection of a high energy neutron or neutral kaon in the Hadron Calorimeter. The combined d-and s-quark purity was 69% and th…
Ética de las biotecnologías
2002
El poder que la Nueva Genética ha puesto en manos de los seres humanos requiere una ética desde la que sea posible tomar decisiones en cuestiones de manipulación genética. El trabajo se propone (1) situar la ética de las biotecnologías en el conjunto de la bioética, (2) señalar los distintos ámbitos de la Nueva Genética que plantean problemas éticos, reconociendo que cada uno de ellos requiere un tratamiento específico, (3) esbozar un marco ético desde el que orientar las respuestas, un marco elaborado desde la ética kantiana, el enfoque de las capacidades de Sen, la ética del discurso y el principio responsabilidad de Jonas, y (4) abordar la cuestión tal vez más candente en el ámbito ético…
Liminality and (Trans)Nationalism in the Rethinking of the African Canadian Subjectivity: Esi Edugyan’s The Second Life of Samuel Tyne
2015
Drawing on the concepts of liminality proposed by Arnold Van Gennep and Victor Turner and Althusser's three ideological tools that nationalism prescribe to be undertaken by individuals who try to become an integral part of a national community, this paper reads Esi Edugyan’s debut novel, The Second Life of Samuel Tyne (2004), as an exploration of the role of literature within the debate about the different positions of black Canadian subjectivity and national adherence. George Elliott Clarke and Rinaldo Walcott polarized the African Canadian criticism by proposing two different theories in an attempt to shape up and (re)define the subjectivity of black Canadians. Clarke advocates to include…
Sulfotransferase-mediated mutagenicity of 1-hydroxymethylpyrene and 4H-cyclopenta[def]chrysen-4-ol and its enhancement by chloride anions.
1993
1-Hydroxymethylpyrene (HMP), a primary benzylic alcohol, and 4H-cyclopenta[def]chrysen-4-ol (OH-CPC), a secondary benzylic alcohol, were investigated for mutagenicity in Salmonella typhimurium (reversion of the his- strain TA98) in the presence of various xenobiotic-metabolizing systems. In the direct test, HMP was inactive and OH-CPC was very weakly active. In the presence of NADPH-fortified postmitochondrial fraction from rat liver (S9/NADPH), no activation of OH-CPC was observed, whereas strong mutagenic effects were elicited by HMP. In the presence of cytosol and 3'-phosphoadenosine-5'-phosphosulfate (PAPS), both alcohols were activated to potent mutagens. For equal mutagenic effects, a…
Biotechnological potential of respiring Zymomonas mobilis: a stoichiometric analysis of its central metabolism.
2013
The active, yet energetically inefficient electron transport chain of the ethanologenic bacterium Zymomonas mobilis could be used in metabolic engineering for redox-balancing purposes during synthesis of certain products. Although several reconstructions of Z. mobilis metabolism have been published, important aspects of redox balance and aerobic catabolism have not previously been considered. Here, annotated genome sequences and metabolic reconstructions have been combined with existing biochemical evidence to yield a medium-scale model of Z. mobilis central metabolism in the form of COBRA Toolbox model files for flux balance analysis (FBA). The stoichiometric analysis presented here sugges…