Search results for "NANOGELS"

Studies of network organization and dynamics of e-beam crosslinked PVPs: From macro to nano

2012

Abstract In this work the influence of poly(N-vinyl pyrrolidone) (PVP) concentration in water on the organization and dynamics of the corresponding macro-/nanogel networks has been systematically investigated. Irradiation has been performed at the same irradiation dose (within the sterilization dose range) and dose rate. In the selected irradiation conditions, the transition between macroscopic gelation and micro-/nanogels formation is observed just below the critical overlap concentration (∼1 wt%), whereas the net prevalence of intra-molecular over inter-molecular crosslinking occurs at a lower polymer concentration (below 0.25 wt%). Dynamic–mechanical spectroscopy has been applied as a cl…

Studies of network structure and dynamics of e-beam crosslinked PVPs: From macro to nano

2011

Much interest has been paid to develop a variety of radiation-crosslinked hydrated polymeric materials, which swell in water but do not dissolve, as biocompatible materials used for wound healing, drug delivery system, surface-coating material for medically used devices, etc. With the aim of establishing design rules to produce hydrogels of controlled size at the nanoscale and desired internal network structure using conventional electron accelerators and set-ups, here we attempt a description in terms of structural and dynamic properties of polymer networks generated through e-beam irradiation of aqueous solutions of the same model polymer, a commercial grade poly(N-vinyl-pyrrolidone), sub…

Large-scale manufacturing of radiation sculptured therapeutic nanogels

2013

Nanogels (NGs), or small particles formed by physically or chemically crosslinked polymer networks, represent a niche in the development of “smart” nanoparticles for drug delivery and diagnostics. Yet, they offerunique advantages over other systems, including a large and flexible surface for multivalent bio-conjugation; an internal 3D aqueous environment for incorporation and protection of (bio)molecular drugs; the possibility to entrap light-activemolecules, metal or mineral nanoparticles for imaging or phototherapeutic purposes; stimuli-responsiveness to achieve temporal and/or site control of the release function and biocompatibility. The availability of inexpensive, robust and versatile…

Radiation engineered nanogels as platforms for medical diagnostics and therapeutic nanodevices

2015

A scalable, single step, synthetic approach for the manufacture of biocompatible, functionalized microgels and nanogels has been developed. Pulsed EB irradiation of PVP aqueous solutions, at relatively low energies per pulse and doses within the sterilization dose range, has led to a variety of ‘as-born’ sterile, functional nanostructures that exhibit a combination of favourable properties which make them suitable as biomedical nanocarriers. Reactive functional groups have been generated by graft copolymerization of functional acrylic monomers. These groups can be used to attach fluorescent probes to the NPs, to bioconjugate ligands of specific cell receptors and to incorporate therapeutics…

Biodistribution of Insulin-Nanogels in Mouse: A Preliminary Study for the Treatment of Alzheimer's Disease

2017

A growing body of evidence shows that Insulin, Insulin Receptor (IR) and IR signaling are involved in brain cognitive functions and their dysfunction is implicated in Alzheimer's disease (AD) neurodegeneration. Thus, administration of insulin could be a strategy for AD treatment. For this aim we have designed, synthesized and characterized a nanogel system (NG) that has been conjugated to insulin molecules (NG-In) to deliver the protein into the brain, as a tool for the development of a new therapy against AD. In our preclinical study in mice, intraperitoneal injection of fluorescent-labeled NG has allowed to determine the biodistribution of NG vs time in the whole body and its clearance th…

FOLATE-DECORATED E-BEAM CROSSLINKED NANOGELS TO ENHANCE UPTAKE BY TUMOR CELLS

2014

Conjugation strategies of insulin to nanogels: new hope for nanogels Alzheimer's disease therapy?

2014

Crosslinking of polymers activated by electrogenerated hydroxyl radicals.

2015

Nanogels (NGs) are systems created by crosslinking of polymers taking nanosized dimensions and they have been proposed for biomedical and pharmaceutical applications due to their soft consistency, biocompatibility and good chemical properties that make them excellent drug delivery agents (1). Differently from typical hydrogels, nanogels are able to dissolve in solvents and to swell releasing the drug molecules loaded in the nano-vector. Furthermore, if properly functionalized with reactive groups, these materials can represent a very interestingly vector for different pharmacological treatments (2). Several methods have been investigated to prepare polymeric nanogels starting from preformed…

Understanding generation of multifunctional nanogels in chemical-free e-beam irradation synthesis

2018

Radiation engineered nanogels are the core of very promising theranostic nanodevoces. They can be produced starting from aqueous solutions of chemically inert polymers by pulsed e-beam irradiation.

Water-borne polymeric nanoparticles for glutathione-mediated intracellular delivery of anticancer drugs

2013

A new family of water-borne, biocompatible and carboxyl- functionalized nanogels was developed for glutathione- mediated delivery of anticancer drugs. Poly(N-vinyl- pyrrolidone)-co-acrylic acid nanogels were generated by e- beam irradiation of aqueous solutions of a crosslinkable polymer, using industrial-type linear accelerators and set- ups. Nanogels physico-chemical properties and colloidal stability, in a wide pH range, were investigated. In vitro cell studies proved that the nanogels are fully biocompatible and able to quantitatively bypass cellular membrane. An anticancer drug, doxorubicin (DOX), was linked to the carboxyl groups of NGs through a spacer containing a disulphide cleavab…