Search results for "NASAL"

showing 10 items of 426 documents

Protective effect of adenylate deaminase (from Penicillium lanoso-viride) against acute infections in mice

1996

We examined the effects of the immunomodulator-adenylate deaminase (E.C. 3.5.4.6) from Penicillium lanoso-viride on experimental mice infections. Prophylactic intraperitoneal administration of adenylate deaminase (ADA) increased survival time and numbers of survivors after infection with Salmonella typhimurium, Pseudomonas aeruginosa and influenza A (H3N2) virus. Protection against influenza virus after intranasal ADA application was also observed. The influence of ADA was time and dose dependent. The most pronounced protection was obtained by administration of 3 U ADA/mice 24 h prior to infection. ADA had no antibiotic effect against these bacterial strains. Protective effects of ADA were …

Salmonella typhimuriumcongenital hereditary and neonatal diseases and abnormalitiesSalmonellamedicine.disease_causeVirusAMP DeaminaseMicrobiologyMicechemistry.chemical_compoundOrthomyxoviridae Infectionsimmune system diseasesCyclosporin amedicineAnimalsMacrophagePseudomonas InfectionsPharmacologyMice Inbred ICRSalmonella Infections AnimalbiologyPseudomonas aeruginosaPenicilliumnutritional and metabolic diseaseshemic and immune systemsbiology.organism_classificationenzymes and coenzymes (carbohydrates)chemistryInfluenza A virusAcute DiseaseImmunologyPenicilliumMice Inbred CBAFemaleNasal administrationTrypan blueImmunopharmacology
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Nasal pressure swings as the measure of inspiratory effort in spontaneously breathing patients with de novo acute respiratory failure.

2022

Abstract Background Excessive inspiratory effort could translate into self-inflicted lung injury, thus worsening clinical outcomes of spontaneously breathing patients with acute respiratory failure (ARF). Although esophageal manometry is a reliable method to estimate the magnitude of inspiratory effort, procedural issues significantly limit its use in daily clinical practice. The aim of this study is to describe the correlation between esophageal pressure swings (ΔPes) and nasal (ΔPnos) as a potential measure of inspiratory effort in spontaneously breathing patients with de novo ARF. Methods From January 1, 2021, to September 1, 2021, 61 consecutive patients with ARF (83.6% related to COVID…

Self-inflicted lung injuryCritical Care and Intensive Care MedicineAcute respiratory failureself-inflicted lung injuryNon-invasive Mechanical ventilationesophageal pressure swingsacute respiratory failure non-invasive mechanical ventilation esophageal pressure swings nasal pressure swings endotracheal intubation COVID-19 respiratory monitoring inspiratory effort self-inflicted lung injuryHumansInspiratory effortendotracheal intubationEsophageal pressure swingsAcute respiratory failure Non-invasive Mechanical ventilation Esophageal pressure swings Nasal pressure swings Endotracheal intubation COVID-19 Respiratory monitoring Inspiratory effort Self-inflicted lung injuryRespiratory Distress Syndromeacute respiratory failurenon-invasive mechanical ventilationNoninvasive VentilationRespiratory monitoringCOVID-19Endotracheal intubationRespiration ArtificialAcute respiratory failure; COVID-19; Endotracheal intubation; Esophageal pressure swings; Inspiratory effort; Nasal pressure swings; Non-invasive Mechanical ventilation; Respiratory monitoring; Self-inflicted lung injuryNasal pressure swingsnasal pressure swingsrespiratory monitoringRespiratory Insufficiencyinspiratory effortCritical care (London, England)
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All'ombra delle due lupe. Gli anni della formazione di 'Battistino' tra Piacenza e Roma (1872-1907)

2022

This chapter analyses the early years and the education of Cardinal Giovanni Battista Nasalli Rocca di Corneliano between Piacenza and Rome.

Settore M-STO/07 - Storia Del Cristianesimo E Delle ChiesePiacenzaGubbioGiovanni Battista Nasalli Roccatwentieth centuryfascismChurchBolognacardinalate
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PEDICLED PERFORATOR FLAPS IN NASAL RECONSTRUCTION: A REVIEW

2014

The use of perforator flaps in face reconstruction is becoming increasingly common. They are particularly useful in nose reconstruction, where they can be tailored to match the complex three-dimensional structure of the nasal concave and convex subunits. In this paper, we present a review of the literature on the use of pedicled perforator flaps in nose reconstruction, discussing current indications and outcomes. Literature on this topic is still limited, with only 12 studies reporting data on 129 reconstructions. Reconstruction of nasal defects with pedicled perforator flaps is a novel and expanding field. It allows for the achievement of good aesthetic results, with a single operation and…

Settore MED/19 - Chirurgia Plastica“perforator flap” “nose” “nasal reconstruction”
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Endoscopic treatment of maxillary sinus mucocele

2004

Settore MED/31 - Otorinolaringoiatriaendoscopic surgery nasal surgery FESS maxillary sinus mucocele sinusitisSettore MED/29 - Chirurgia Maxillofacciale
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Management of Naso-Septal Deformity in Childhood: Long Term Results

2009

Settore MED/31 - Otorinolaringoiatrianasal surgery septoplasty rhinoplasty pediatric surgery traumaSettore MED/19 - Chirurgia Plastica
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Benralizumab Effectiveness in Severe Eosinophilic Asthma with and without Chronic Rhinosinusitis with Nasal Polyps: A Real-World Multicenter Study

2021

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) affects around 60% of patients with severe eosinophilic asthma (SEA). Benralizumab was recently approved for SEA add-on treatment. Objective: To assess the real-world effectiveness of benralizumab in SEA with or without CRSwNP. Methods: We conducted a multicenter observational study, including patients with SEA treated with benralizumab for 24 weeks in 12 Italian specialized facilities. Asthma exacerbations, Asthma Control Test (ACT), lung function, oral corticosteroid (OCS) dosage, and eosinophil and basophil count in peripheral blood were recorded at baseline and after 4, 12, and 24 weeks. The 22-item Sino-Nasal Outcome Test (S…

Severe asthmaVital capacitymedicine.medical_specialtymedicine.drug_classSettore MED/10 - Malattie Dell'Apparato RespiratorioAntibodies Monoclonal HumanizedFEV1/FVC ratiochemistry.chemical_compoundNasal PolypsInternal medicinemedicineHumansImmunology and AllergyNasal polypsAnti-Asthmatic AgentsIL-5Nasal polypbusiness.industryMinimal clinically important differenceBenralizumabFunctional endoscopic sinus surgeryrespiratory systemEosinophilBenralizumabmedicine.diseaseAsthmaChronic rhinosinusitismedicine.anatomical_structureReal-worldchemistryChronic rhinosinusitiCorticosteroidbusinessHumanThe Journal of Allergy and Clinical Immunology: In Practice
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Navigation accuracy after automatic- and hybrid-surface registration in sinus and skull base surgery.

2016

Objective Computer-aided-surgery in ENT surgery is mainly used for sinus surgery but navigation accuracy still reaches its limits for skull base procedures. Knowledge of navigation accuracy in distinct anatomical regions is therefore mandatory. This study examined whether navigation accuracy can be improved in specific anatomical localizations by using hybrid registration technique. Study design Experimental phantom study. Setting Operating room. Subjects and methods The gold standard of screw registration was compared with automatic LED-mask-registration alone, and in combination with additional surface matching. 3D-printer-based skull models with individual fabricated silicone skin were u…

Skin NeoplasmsSiliconeslcsh:MedicineSurgical and Invasive Medical ProceduresDermatologyResearch and Analysis MethodsParanasal SinusesMedicine and Health SciencesHumanslcsh:ScienceMusculoskeletal SystemSkin TumorsSkeletonSkull BaseTitaniumExperimental Designlcsh:RSkullChemical CompoundsBiology and Life SciencesCancers and NeoplasmsOtolaryngological ProceduresChemistrySurgery Computer-AssistedOncologyResearch DesignPhysical Scienceslcsh:QAnatomyPlastic Surgery and Reconstructive TechniquesResearch ArticleChemical ElementsPloS one
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Poly(γ-Glutamic Acid) as an Exogenous Promoter of Chondrogenic Differentiation of Human Mesenchymal Stem/Stromal Cells

2015

Cartilage damage and/or aging effects can cause constant pain, which limits the patient's quality of life. Although different strategies have been proposed to enhance the limited regenerative capacity of cartilage tissue, the full production of native and functional cartilaginous extracellular matrix (ECM) has not yet been achieved. Poly(γ-glutamic acid) (γ-PGA), a naturally occurring polyamino acid, biodegradable into glutamate residues, has been explored for tissue regeneration. In this work, γ-PGA's ability to support the production of cartilaginous ECM by human bone marrow mesenchymal stem/stromal cells (MSCs) and nasal chondrocytes (NCs) was investigated. MSC and NC pellets were cultur…

Stromal cellBiomedical EngineeringType II collagenCell Culture TechniquesBioengineeringBiochemistryBiomaterialsExtracellular matrixTransforming Growth Factor beta1ChondrocytesNasal CartilagesmedicineHumansAggrecansAggrecanCells CulturedGlycosaminoglycansExtracellular Matrix ProteinsChemistryCartilageMesenchymal stem cellMesenchymal Stem CellsSOX9 Transcription FactorOriginal ArticlesChondrogenesisMolecular biologyCulture Mediamedicine.anatomical_structureBiochemistryPolyglutamic AcidCulture Media ConditionedCalciumCollagenStromal CellsChondrogenesisType I collagen
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Lesions of the dopaminergic innervation of the nucleus accumbens medial shell delay the generation of preference for sucrose, but not of sexual phero…

2011

Male sexual pheromones are rewarding stimuli for female mice, able to induce conditioned place preference. To test whether processing these natural reinforcing stimuli depends on the dopaminergic innervation of the nucleus accumbens, as for other natural rewards, we compare the effects of specific lesions of the dopaminergic innervation of the medial shell of the nucleus accumbens on two different appetitive behaviours, ‘pheromone seeking’ and sucrose preferential intake. Female mice, with no previous experience with either adult male chemical stimuli or with sucrose, received injections of 6-hydroxydopamine (or vehicle) in the medial shell of the accumbens. Then, we analyzed their preferen…

Sucrosemedicine.medical_specialtyTime FactorsVomeronasal organMotor ActivityNucleus accumbensNucleus Accumbensnatural rewardvomeronasal systemFood PreferencesMiceBehavioral Neurosciencechemistry.chemical_compoundRewardmotivationDopamineInternal medicinemedicineAnimalsSex AttractantsOxidopamineAccumbensSucrose preferenceNeophobiaDopaminergicmedicine.diseaseConditioned place preferenceEndocrinologychemistryNerve DegenerationPheromoneFemaledopaminePsychologyNeuroscienceOxidopaminemedicine.drug
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