Search results for "NASH"

Multiproduct trading with a common agent under complete information: Existence and characterization of Nash equilibrium

2014

This paper focuses on oligopolistic markets in which indivisible goods are sold by multiproduct firms to a continuum of homogeneous buyers, with measure normalized to one, who have preferences over bundles of products. Our analysis contributes to the literature on private, delegated agency games with complete information, extending the insights by Chiesa and Denicolò (2009) to multiproduct markets with indivisibilities and where the agent's preferences need not be monotone. By analyzing a kind of extended contract schedules -mixed bundling prices- that discriminate on exclusivity, the paper shows that efficient equilibria always exist in such settings. There may also exist inefficient equil…

- STRATEGIC PIGOUVIAN TAXATION, STOCK EXTERNALITIES AND POLLUTING NON-RENEWABLE RESOURCES

2001

This paper extends Wirl and Dockner¿s (1995) model designed to analyze the long-term bilateral interdependence between a resource exporting cartel and a coalition of resource importing country governments. Firstly, depletion effects are introduced into the analysis of the intertemporal properties of a pigouvian tax. Secondly, the feedback Stackelberg equilibria are computed. The results show that the dynamics of the tax depends critically on the level of the marginal environmental damage. Moreover, they also show that the tax defined by the Markov-perfect Nash equilibrium is a neutral pigouvian tax in the sense that it only corrects the market inefficiency caused by the stock externality. H…

Evolutionary design optimization with Nash games and hybridized mesh/meshless methods in computational fluid dynamics

2012

A Novel Multi-step Finite-State Automaton for Arbitrarily Deterministic Tsetlin Machine Learning

2020

Due to the high energy consumption and scalability challenges of deep learning, there is a critical need to shift research focus towards dealing with energy consumption constraints. Tsetlin Machines (TMs) are a recent approach to machine learning that has demonstrated significantly reduced energy usage compared to neural networks alike, while performing competitively accuracy-wise on several benchmarks. However, TMs rely heavily on energy-costly random number generation to stochastically guide a team of Tsetlin Automata (TA) to a Nash Equilibrium of the TM game. In this paper, we propose a novel finite-state learning automaton that can replace the TA in TM learning, for increased determinis…

PSD3 downregulation confers protection against fatty liver disease

2022

Fatty liver disease (FLD) is a growing health issue with burdening unmet clinical needs. FLD has a genetic component but, despite the common variants already identified, there is still a missing heritability component. Using a candidate gene approach, we identify a locus (rs71519934) at the Pleckstrin and Sec7 domain-containing 3 (PSD3) gene resulting in a leucine to threonine substitution at position 186 of the protein (L186T) that reduces susceptibility to the entire spectrum of FLD in individuals at risk. PSD3 downregulation by short interfering RNA reduces intracellular lipid content in primary human hepatocytes cultured in two and three dimensions, and in human and rodent hepatoma cell…

Macrophage MerTK promotes profibrogenic cross-talk with hepatic stellate cells via soluble mediators

2022

Background & aims: Activation of Kupffer cells and recruitment of monocytes are key events in fibrogenesis. These cells release soluble mediators which induce the activation of hepatic stellate cells (HSCs), the main fibrogenic cell type within the liver. Mer tyrosine kinase (MerTK) signaling regulates multiple processes in macrophages and has been implicated in the pathogenesis of non-alcoholic steatohepatitis-related fibrosis. In this study, we explored if MerTK activation in macrophages influences the profibrogenic phenotype of HSCs. Methods: Macrophages were derived from THP-1 cells or differentiated from peripheral blood monocytes towards MerTK+/CD206+/CD163+/CD209- macrophages. Th…

AGILE 3+ Score for the Diagnosis of Advanced Fibrosis and for Predicting Liver-related Events in NAFLD.

2022

Background & aims: We aimed to assess the diagnostic accuracy of AGILE 3+, a recently developed score based on the combination of aspartate aminotransferase/alanine aminotransferase ratio, platelet count, diabetes status, sex, age, and liver stiffness measurement (LSM) by transient elastography, when compared with Fibrosis-4 (FIB-4) and LSM, for the diagnosis of advanced fibrosis and for the prediction of liver-related events (LREs) occurrence in patients with NAFLD. Methods: A total of 614 consecutive patients with biopsy-proven NAFLD or clinical diagnosis of NAFLD-related compensated cirrhosis were enrolled. LREs were recorded during follow-up. FIB-4, LSM by transient elastography (Fi…

WEPP calibration for improved predictions of interrill erosion in semi-arid to arid environments

2013

Abstract Modeling soil erosion contributes to the understanding of the erosion processes and needs to predict accurately the erosion rates under different environmental conditions. Few studies have investigated the WEPP's applicability for arid and semi-arid conditions that differ from those where the model was developed. This research was carried out to evaluate and improve the WEPP model for arid and semiarid regions for interrill erosion using a rainfall simulator at plot scale. The results showed that measured interrill erosion rates ranged from 9.3 × 10− 6 to 89.6 × 10− 6 kg m− 2 s− 1. In comparison, the WEPP-interrill erosion prediction values were on average 14.5 times lower than the…

Testing the long term applicability of USLE-M equation at a olive orchard microcatchment in Spain

2016

Abstract Universal Soil Loss Equation USLE-based erosion models have been used extensively to complement erosion measurements, to understand the interactions of the different geophysical features into erosion processes and to assess adequate alternative management practices and scenarios analyses. Despite its proved usefulness on different land-uses around the world, there is an urgent need to set up simple tools which do not require an advanced management expertise in terms of both choose of model parameters and calculation ability and which are accurate particularly at the event scale. In this paper the suitability of the Modified USLE (USLE-M) model at the event and the annual scale were…

The effect of early or late R&D inbound alliance on innovation

2016

In the research-and-development (R&D) supply chain, firms can agree an inbound alliance at different times along the R&D process; this decision affects the supplier's effort and the innovation that firms achieve at the end of the agreement. Because the supplier's effort is not entirely observable, firms cannot enforce effort contractually. Early contracts demand greater effort and offer risk-sharing opportunities; in late contracts suppliers have a stronger ex-ante bargaining-power position because of the shorter (and less risky) contract length and the experience suppliers already have. This study argues that later inbound alliances allow a higher innovation value when both partner…