Search results for "NAV"
showing 10 items of 2523 documents
Skandinavia
1565
Eero ja Erkki Fredriksonin säätiö
Vide kā dzīves telpas vieta jeb par to - kā domāt vidi
1999
Visi it kā zin, ko saprast ar jēdzienu „vide” līdz tam, kad izvirza jautājumu: kas ir vide? Līdz ar jaunākajiem laikiem arī Latvijā „vide” kļuvusi par vārdu, ko salīdzinoši bieži lieto gan ikdienas apziņas līmenī, gan teorētiskajā domā. Par vidi zinību vēsturē ir blīvs semantiskais lauks. Pieņemsim, ka šoreiz nav nepieciešama stingra definīcija, bet gan domāšana par to, kā saprast vidi un par to runāt humanitārā un sociālā diskursā. Mūsu valoda par vidi kā veselo lielā mērā ir veidota pēc analoģijas principa. Ja tā nebūtu, tad runa būtu tikai par apstākļiem, par vidi reduktīvā nozīmē u.tml., bet mazsvarīgāk nav, kā tiek ietekmēta vides veidošanās līdz ar cilvēka „domāšanas ainavu” .Izvēloti…
Autentiski teksti valodas apguvē: teorijas, pieejas un pieredzes stāsti
2020
Lingvodidaktisks izdevums, kas paredzēts valodniecības un pedagoģijas studiju programmu īstenošanai universitātēs, svešvalodu metodiķu un pedagogu profesionālajai pilnveidei. Izdevumā īpaša uzmanība ir pievērsta lingvistiskās ainavas pieejas un tekstu izmantojuma teorētiskajam pamatojumam un praksei, mācot latviešu valodu kā svešvalodu Latvijā un ārvalstīs.
Microstructural evaluation and recommendations for face masks in community use to reduce the transmission of respiratory infectious diseases
2022
Funding Information: A.K., H.Y. and R.J. also acknowledges the funding through Academy of Finland BESIMAL (Decision No. 334197) and Aalto University, Department of Communications and Networking. This work has also received funding in part from the EPSRC UK (grant number EP/R012091/1). A.K. would also like to thank Mr. Volkan Kaplan for the fruitful discussions in the early concept generation. Publisher Copyright: © 2022 The Author(s) Background and Objective: Recommendations for the use of face masks to prevent and protect against the aerosols (≤5µm) and respiratory droplet particles (≥5µm), which can carry and transmit respiratory infections including severe acute respiratory syndrome coro…
Genome sequence of SeIV-1, a novel virus from the Iflaviridae family infective to Spodoptera exigua
2011
Analysis of the transcriptome of Spodoptera exigua larvae revealed the presence of several ESTs with homology to virus of the order Picornavirales and with the highest similarity to Infectious flacherie virus (Iflaviridae) that infects Bombyx mori larvae. Iflaviridae is a recently defined family of insect-infecting viruses that consist of positive single strand RNA genomes translated into a single polyprotein of around 3000 amino acids long. Using the sequence information derived from the obtained ESTs, we have completed the genomic sequence of this virus. The novel S. exigua iflavirus (SeIV-1) has a genome of 10.3 kb and codes for a 3222 aa polyprotein. Expression analysis has revealed the…
Human Papillomavirus Type 16 E7 Peptide-Directed CD8+ T Cells from Patients with Cervical Cancer Are Cross-Reactive with the Coronavirus NS2 Protein
2003
ABSTRACTHuman papillomavirus type 16 (HPV16) E6 and E7 oncoproteins are required for cellular transformation and represent candidate targets for HPV-specific and major histocompatibility complex class I-restricted CD8+-T-cell responses in patients with cervical cancer. Recent evidence suggests that cross-reactivity represents the inherent nature of the T-cell repertoire. We identified HLA-A2 binding HPV16 E7 variant peptides from human, bacterial, or viral origin which are able to drive CD8+-T-cell responses directed against wild-type HPV16 E7 amino acid 11 to 19/20 (E711-19/20) epitope YMLDLQPET(T) in vitro. CD8+T cells reacting to the HLA-A2-presented peptide from HPV16 E711-19(20)recogni…
Immune responses during COVID-19 infection
2020
International audience; Over the past 16 years, three coronaviruses (CoVs), severe acute respiratory syndrome CoV (SARS-CoV) in 2002, Middle East respiratory syndrome CoV (MERS-CoV) in 2012 and 2015, and SARS-CoV-2 in 2020, have been causing severe and fatal human epidemics. The unpredictability of coronavirus disease-19 (COVID-19) poses a major burden on health care and economic systems across the world. This is caused by the paucity of in-depth knowledge of the risk factors for severe COVID-19, insufficient diagnostic tools for the detection of SARS-CoV-2, as well as the absence of specific and effective drug treatments. While protective humoral and cellular immune responses are usually m…
Molecular Basis of SARS-CoV-2 Nsp1-Induced Immune Translational Shutdown as Revealed by All-Atom Simulations.
2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic represents the most severe global health crisis in modern human history. One of the major SARS-CoV-2 virulence factors is nonstructural protein 1 (Nsp1), which, outcompeting with the binding of host mRNA to the human ribosome, triggers a translation shutdown of the host immune system. Here, microsecond-long all-atom simulations of the C-terminal portion of the SARS-CoV-2/SARS-CoV Nsp1 in complex with the 40S ribosome disclose that SARS-CoV-2 Nsp1 has evolved from its SARS-CoV ortholog to more effectively hijack the ribosome by undergoing a critical switch of Q/E158 and E/Q159 residues that perfects Nsp1's interactions…
SARS-CoV-2 envelope protein topology in eukaryotic membranes
2020
Coronavirus E protein is a small membrane protein found in the virus envelope. Different coronavirus E proteins share striking biochemical and functional similarities, but sequence conservation is limited. In this report, we studied the E protein topology from the new SARS-CoV-2 virus both in microsomal membranes and in mammalian cells. Experimental data reveal that E protein is a single-spanning membrane protein with the N-terminus being translocated across the membrane, while the C-terminus is exposed to the cytoplasmic side (Nt lum /Ct cyt ). The defined membrane protein topology of SARS-CoV-2 E protein may provide a useful framework to understand its interaction with other viral and ho…
Extraction d'un graphe de navigabilité à partir d'un nuage de points 3D enrichis
2017
International audience; Ce travail se place dans le cadre général du projet ANR pLaTINUM lié à la navigation autonome et plus parti-culièrement à la génération de cartes pour la navigation basée perception. Il consiste à développer une nouvelle méthode pour résumer une carte 3D (un nuage dense de points 3D) et extraire un graphe de navigabilité facilitant l'utilisation de cette carte par des systèmes de navigation à ressources matérielles limitées (smart-phones, voitures, robots.. .). Cette méthode vise à ex-traire les régions les plus saillantes de l'environnement étudié afin de construire une carte récapitulative. Ce processus de résumé de carte basé sur la vision est appliqué d'une façon…