Search results for "NCS"
showing 10 items of 54 documents
Stress test based on Oliver Wyman in Bank of Spain: an evaluation
2016
This paper, based on econometric techniques, has done a study to improve the predictions of the stress test, concerning the estimation of impairment losses. The main results obtained are: 1) the impact of the explanatory variables on the impairment loss is different at stages of growth, compared to times of recession; 2) there is a certain inertia of the dependent variable, but this inertia is different in intensity, and even the sign in the growth stages concerning the stages of recession; 3) of the explanatory variables, nominal GDP and equity are those that have a greater impact on the impairment loss; 4) finally, the two dummy variables that assess the impact of adjustment to market val…
Green Nanocomposites-Based on PLA and Natural Organic Fillers
2017
Over the past decades, many efforts have been carried out for the development of novel green nanocomposites based on biopolymers and natural organic nanofillers. Indeed, these nanocomposites could replace some oil-derived polymers and thus helping to overcome environmental problems. In this regard, poly (lactic acid) (PLA) as matrix and polysaccharide nanocrystals (cellulose, chitin, and starch) as bio-based nanoreinforcements are the most promising components to obtain high-performance green nanocomposites. This chapter covers the basic features of PLA and polysaccharide nanocrystals derived from biomass-based raw materials such as cellulose, chitin, and starch. In particular, this chapter…
Drug connectivity mapping and functional analysis reveal therapeutic small molecules that differentially modulate myelination
2022
Disruption or loss of oligodendrocytes (OLs) and myelin has devastating effects on CNS function and integrity, which occur in diverse neurological disorders, including Multiple Sclerosis (MS), Alzheimer’s disease and neuropsychiatric disorders. Hence, there is a need to develop new therapies that promote oligodendrocyte regeneration and myelin repair. A promising approach is drug repurposing, but most agents have potentially contrasting biological actions depending on the cellular context and their dose-dependent effects on intracellular pathways. Here, we have used a combined systems biology and neurobiological approach to identify compounds that exert positive and negative effects on olig…
Efficient Synthesis and X-ray Structure of [1,2,4]Triazolo[4,3-a]pyridines via Oxidative Cyclization Using N-Chlorosuccinimide (NCS)
2021
Triazolopyridines are a family of compounds that, owing to their biological activity, have many pharmaceutical applications. In this study, 3-(pyridine-4-yl)-[1,2,4]triazolo[4,3-a]pyridine and 6-bromo-3-(pyridine-4-yl)-[1,2,4]triazolo[4,3-a]pyridine were synthesized by using the chlorinated agent NCS for hydrazones under very mild conditions. The characterization of these compounds was achieved by 1H NMR, 13C NMR, FTIR, MS and X-ray diffraction. The compound 3-(pyridine-4-yl)-[1,2,4]triazolo[4,3-a]pyridine was crystallized in the monoclinic space group P 21/c with a = 15.1413(12), b = 6.9179(4), c = 13.0938(8) Å, β = 105.102(6)°, V = 1324.16(16)Å3, Z = 4, and R = 0.0337. Also compound 6-bro…
Motor Conduction Studies and Handgrip in Hereditary TTR Amyloidosis: Simple Tools to Evaluate the Upper Limbs
2022
PurposeHereditary transthyretin amyloidosis with polyneuropathy (ATTRv) is caused by mutations in the TTR gene, leading to misfolded monomers that aggregate generating amyloid fibrils. The clinical phenotype is heterogeneous, and characterized by a multisystemic disease affecting the sensorimotor and autonomic functions along with other organs.Materials and MethodsAll the patients were assessed by complete neurological assessment, neurophysiological evaluation, of the median nerve, and handgrip analysis. The data are presented as means and standard deviations. Parametric and non-parametric assessments have been performed to identify differences between groups. Pearson's correlation has been…
Determinants of interest margins in Spanish credit institutions before and after the 2008 financial crash
2017
As interest margins of credit institutions affect economic performance of countries, finding out which are the main determinants of their evolution is a research task of great interest at current times. This is the purpose of the present paper as regards to the Spanish case over the period 2004-2012. Based on the econometric contributions by Ho and Saunders (1981) and some of its extensions, the authors develop a model that includes as explanatory variables the factors usually examined in the literature and other singular variables that might be relevant. Particularly, the rate of leverage, the quality of their assets measured according to their risk, and the profit obtained from the sellin…
Los empleados de las entidades de créditos españolas, desde una óptica de responsabilidad social empresarial
2015
La exigencia de la sociedad occidental de considerar algo más que beneficios económicos por parte de las entidades de crédito, requiere y reclama beneficios sociales. Es cada vez mayor, el convencimiento de que la repercusión de las actividades de una entidad de crédito en los derechos humanos de sus empleados y de las comunidades locales, sobrepasa el ámbito de los derechos laborales. El objetivo es evaluar si las entidades de crédito con mayor sensibilidad hacia Responsabilidad Social Empresarial implementan prácticas de valores compartidos con sus empleados. El trabajo de campo se realizó a través de una encuesta postal contestada por los responsables de la Responsabilidad Social Empresa…
Zvaigžņotā Debess: 2009, Pavasaris (203)
2009
Contents: E.R.Mustel, President of the Astronomical Council of the USSR Academy of Sciences. Congratulations to Editorial Board of “Zvaigžņotā debess” ; Z.Alksne. Gould’s Belt ; I.Daube. At the Radioastrophysical Observatory of the Latvian Academy of Sciences ; Z.Alksne, A.Alksnis. Lopsided Galaxies ; A.Alksnis. HII Region Gum 29 – a Stellar Nursery ; D.Docenko. On Collision of Asteroid 2008 TC3 with the Earth ; V.Lapoška. On „Leap Second” ; I.Vilks, M.Gills. Beginning of the International Year of Astronomy in Paris: Impressions by Latvian Delegates ; J.Jaunbergs. Equatorial Ridge on Iapetus ; M.Sudārs. Space Shuttle Is Not Likely to Retire Next Year ; I.Vilks. Planet Satellite Names in Lat…