Search results for "NEAT"
showing 10 items of 229 documents
ALS-linked FUS mutations confer loss and gain of function in the nucleus by promoting excessive formation of dysfunctional paraspeckles
2019
Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). Mutant FUS is known to confer cytoplasmic gain of function but its effects in the nucleus are less understood. FUS is an essential component of paraspeckles, subnuclear bodies assembled on a lncRNA NEAT1. Paraspeckles may play a protective role specifically in degenerating spinal motor neurons. However it is still unknown how endogenous levels of mutant FUS would affect NEAT1/paraspeckles. Using novel cell lines with the FUS gene modified by CRISPR/Cas9 and human patient fibroblasts, we found that endogenous levels of mutant FUS cause accumulation of NEAT1 isoforms and paraspeckles. However, despite only mild cytoplasm…
Multiplicative loops of 2-dimensional topological quasifields
2015
We determine the algebraic structure of the multiplicative loops for locally compact $2$-dimensional topological connected quasifields. In particular, our attention turns to multiplicative loops which have either a normal subloop of positive dimension or which contain a $1$-dimensional compact subgroup. In the last section we determine explicitly the quasifields which coordinatize locally compact translation planes of dimension $4$ admitting an at least $7$-dimensional Lie group as collineation group.
Area minimizing projective planes on the projective space of dimension 3 with the Berger metric
2016
Abstract We show that, among the projective planes embedded into the real projective space R P 3 endowed with the Berger metric, those of least area are exactly the ones obtained by projection of the equatorial spheres of S 3 . This result generalizes a classical result for the projective spaces with the standard metric.
Partial spreads in finite projective spaces and partial designs
1975
A partial t-spread of a projective space P is a collection 5 p of t-dimensional subspaces of P of the same order with the property that any point of P is contained in at most one element of 50. A partial t-spread 5 p of P is said to be a t-spread if each point of P is contained in an element of 5P; a partial t-spread which is not a spread will be called strictly partial. Partial t-spreads are frequently used for constructions of affine planes, nets, and Sperner spaces (see for instance Bruck and Bose [5], Barlotti and Cofman [2]). The extension of nets to affine planes is related to the following problem: When can a partial t-spread 5 ~ of a projective space P be embedded into a larger part…
Zur Hyperebenenalgebraisierung in desargues-Schen projektiven Verbandsgeometrien
1991
As a completion and extension of a result of A. Day and D. Pickering [5] we obtain the following structure theorem in the conceptual frame of projective lattice geometries: In a Desarguesian projective geometry the subgeometry of every at least one-dimensional hyperplane is module induced.
Foliations, Lineations and Lattice Preferred Orientation
1998
Many microstructures in rocks are defined by a preferred orientation of minerals or fabric elements. We distinguish foliations, lineations and lattice-preferred orientation.
Dorsal Column Nuclei Neural Signal Features Permit Robust Machine-Learning of Natural Tactile- and Proprioception-Dominated Stimuli
2020
Neural prostheses enable users to effect movement through a variety of actuators by translating brain signals into movement control signals. However, to achieve more natural limb movements from these devices, the restoration of somatosensory feedback is required. We used feature-learnability, a machine-learning approach, to assess signal features for their capacity to enhance decoding performance of neural signals evoked by natural tactile and proprioceptive somatosensory stimuli, recorded from the surface of the dorsal column nuclei (DCN) in urethane-anesthetized rats. The highest performing individual feature, spike amplitude, classified somatosensory DCN signals with 70% accuracy. The hi…
An integrated assessment of the Good Environmental Status of Mediterranean Marine Protected Areas
2022
Este artículo contiene 11 páginas, 2 figuras, 2 tablas.
On some new reports on the spider fauna of Italy and Sicily (Arachnida Araneae)
2022
New spiders (Arachnida Araneae) from Sicily (Italy) are reported, some new for Italy, in this paper. Particularly, twelve genera and sixteen new species are examined: Agelena orientalis C.L. Koch, 1837; Cyclosa algerica Simon, 1885; Larinia lineata (Lucas, 1846); Argenna patula (Simon, 1874), Lathys arabs Simon, 1910, Marilynia bicolor (Simon, 1870), Canariphantes zonatus (Simon, 1884), Cresmatoneta mutinensis (Canestrini, 1868), Diplocephalus graecus (O. Pickard-Cambridge, 1873), Lepthyphantes leprosus (Ohlert, 1865), Ostearius melanopygius (O. Pickard-Cambridge, 1880), Pelecopsis bucephala (O. Pickard-Cambridge, 1875), Pelecopsis inedita (O. Pickard-Cambridge, 1875), Lasaeola convexa (Bla…
The Diapause Lipidomes of Three Closely Related Beetle Species Reveal Mechanisms for Tolerating Energetic and Cold Stress in High-Latitude Seasonal E…
2020
During winter insects face energetic stress driven by lack of food, and thermal stress due to sub-optimal and even lethal temperatures. To survive, most insects living in seasonal environments such as high latitudes, enter diapause, a deep resting stage characterized by a cessation of development, metabolic suppression and increased stress tolerance. The current study explores physiological adaptations related to diapause in three beetle species at high latitudes in Europe. From an ecological perspective, the comparison is interesting since one species (Leptinotarsa decemlineata) is an invasive pest that has recently expanded its range into northern Europe, where a retardation in range expa…