Search results for "NEFA"
showing 8 items of 18 documents
Regulation of the activity of the Cholesteryl Ester Tranfer Protein (CETP) : electrostatics interactions with carboxylic derivatives (Non Esterified …
1997
In human plasma, the cholesteryl ester transfer protein (CETP) plays a key role in lipoprotein metabolism by promoting the net mass transfer of cholesteryl esters from HDL towards apoB-containing lipoproteins, and the transfer of triglycerides from VLDL towards HDL and LDL. Thus CETP arises as a potentially important factor in plasma lipoproteins metabolism, a statement which raised a considerable interest in identifying the factors which may regulate CETP activity.In our in vitro studies, we demonstrated that amphipathic molecules (non esterified fatty acids and retinoic acids) constituted of one carboxylic head group and one hydrophobic carbon chain are able to increase the cholesteryl es…
Multigenerational study of the obesogen effects of bisphenol S after a perinatal exposure in C57BL6/J mice fed a high fat diet.
2021
International audience; Background : Bisphenol S is an endocrine disruptor exhibiting metabolic disturbances, especially following perinatal exposures. To date, no data are available on the obesogen effects of BPS in a mutligenerational issue.Objectives : We investigated obesogen effects of BPS in a multigenerational study by focusing on body weight, adipose tissue and plasma parameters in male and female mice.Methods : Pregnant C57BL6/J mice were exposed to BPS (1.5 μg/kg bw/day ie a human equivalent dose of 0.12 μg/kg bw/day) by drinking water from gestational day 0 to post natal day 21. All offsprings were fed with a high fat diet during 15 weeks. Body weight was monitored weekly and fat…
Drug-Induced Liver Injury Associated With Antidepressive Psychopharmacotherapy: An Explorative Assessment Based on Quantitative Signal Detection Usin…
2015
Drug-induced liver injury is a major problem of pharmacotherapy and is also frequent with antidepressive psychopharmacotherapy. However, there are only few studies using a consistent methodologic approach to study hepatotoxicity of a larger group of antidepress ants. We performed a quantitative signal detection analysis using data from the Uppsala Monitoring Centre from the WHO that records adverse drug reaction (ADR) data from worldwide sources; we retrieved substance- and country-specific (Australia, France, Germany, Italy, Spain, the United Kingdom, and the United States) ADR data and calculated reporting odds ratios as measures for disproportionality within a case/noncase approach. To a…
Effect of propylene glycol on pre- and post-partum performance by dairy ewes
2005
This study was carried out in order to determine the effects, after feeding propylene glycol to Valle del Belice ewes 30 days prepartum and 30 days postpartum, on metabolic profiles, body-condition score, milk yield, milk composition, milk clotting ability and the performance of suckling lambs. Ewes were blocked by parity, body-condition score and previous milk production, and assigned randomly to either a control diet or a diet containing propylene glycol fed at the rate of 80 g/ewe/day (low PG) or 160 g/ewe/day (high PG). Feeding propylene glycol prepartum decreased the concentration of BHBA and NEFA and increased the concentration of glucose in the ewes’ plasma. Milk yield from ewes fed …
Physical Activity Differentially Affects the Cecal Microbiota of Ovariectomized Female Rats Selectively Bred for High and Low Aerobic Capacity
2015
The gut microbiota is considered a relevant factor in obesity and associated metabolic diseases, for which postmenopausal women are particularly at risk. Increasing physical activity has been recognized as an efficacious approach to prevent or treat obesity, yet the impact of physical activity on the microbiota remains under-investigated. We examined the impacts of voluntary exercise on host metabolism and gut microbiota in ovariectomized (OVX) high capacity (HCR) and low capacity running (LCR) rats. HCR and LCR rats (age = 27 wk) were OVX and fed a high-fat diet (45% kcal fat) ad libitum and housed in cages equipped with (exercise, EX) or without (sedentary, SED) running wheels for 11 wk (…
Miega līdzekļu nozīmēšanas tendences
2021
Mūsdienās ar miega traucējumiem sirgst arvien vairāk cilvēku, tāpēc aktuāls kļūst jautājums par mēķtiecīgu miega traucējumu diagnostiku un multidisciplināru miega traucējumu ārstēšanu, ietverot atbilstošu farmakoloģisku un nefarmakoloģisku ārstēšanu. Maģistra darbs “Miega līdzekļu nozīmēšanas tendences” tika izveidots ar mērķi izvērtēt miega traucējumu ārstēšanas paradumus. Darbs sastāv no 2 daļām - teorētiskās un praktisās. Teorētiskā darba daļa tika izveidota, pielietojot literatūru latviešu un angļu valodā. Praktiskā darba daļa tika realizēta kā kvantitatīvs šķērsgrizuma pētījums, kura ietvaros tika izveidotas 3 anketas. Praktiski strādājoši medicīnas un farmācija nozares speciālisti (ģi…
Nefarmakoloģiskās atsāpināšanas metodes jaundzimušo intensīvās terapijas nodaļā
2018
Bakalaura darba tēma – Nefarmakoloģiskās atsāpināšanas metodes jaundzimušo intensīvās terapijas nodaļā. Šī tēma ir aktuāla, jo ik gadu pasaulē nāk ap 15 miljoniem bērnu , no kuriem vismaz viens no 10 jaundzimušajiem piedzimst pirms laika. Savukārt Latvijā katru gadu pirms laika jeb agrāk par pilnām 37 grūtniecības nedēļām dzimst vairāk nekā 1000 bērni, tie ir aptuveni 6% no kopējā dzimušo skaita. Darba izstrādāšanas mērķis - Noskaidrot un analizēt nefarmakoloģisko atsāpināšanas metožu izmantošanu procedūru sāpju novēršanai jaundzimušajiem intensīvās terapijas nodaļā. Pētniecības uzdevumi ir apkopot un analizēt literatūru par procedūru sāpēm jaundzimušajiem un nefarmakoloģiskām atsāpināšanas…
De joven a mujer: persistencia de prácticas culturales en los procesos de definición de la identidad y de la pertenencia en las jóvenes de origen ext…
2016
La experiencia de la migración altera la linealidad de las relaciones intergeneracionales, tanto en el plano de los valores morales, como en aquello cultural, al ser un evento/experiencia de completo cambio de la realidad familiar (Scabini & Rossi, 2008) e del ambiente de vida (Yeoh, 2000). Las características y los tiempos de transformación dependen sobre todo, del tipo de relación entre la familia inmigrada y la sociedad que la acoge, del espacio social accesible para los inmigrados de segunda generación y del tiempo empleado por la estructura familiar en la reelaboración de los valores tradicionales de pertenencia. La relación entre las generaciones que se define, por muchos padres extra…