Search results for "NEO"
showing 10 items of 41983 documents
Metabolic Changes in Tumor Microenvironment: How Could They Affect γδ T Cells Functions?
2021
The metabolic changes that occur in tumor microenvironment (TME) can influence not only the biological activity of tumor cells, which become more aggressive and auto sustained, but also the immune response against tumor cells, either producing ineffective responses or polarizing the response toward protumor activity. γδ T cells are a subset of T cells characterized by a plasticity that confers them the ability to differentiate towards different cell subsets according to the microenvironment conditions. On this basis, we here review the more recent studies focused on altered tumor metabolism and γδ T cells, considering their already known antitumor role and the possibility of manipulating th…
Extracellular Vesicles as Shuttles of Tumor Biomarkers and Anti-Tumor Drugs
2014
Extracellular vesicles (EV) include vesicles released by either normal or tumor cells. EV may exceed the nanometric scale (microvesicles), or to be within the nanoscale, also called exosomes. Thus, it appears that only exosomes and larger vesicles may have the size for potential applications in nanomedicine, in either disease diagnosis or therapy. This is of particular interest for research in cancer, also because the vast majority of existing data on EV are coming from pre-clinical and clinical oncology. We know that the microenvironmental features of cancer may favor cell-to-cell paracrine communication through EV, but EV have been purified, characterized, and quantified from plasma of tu…
Comparative histological and immunohistochemical study of ameloblastomas and ameloblastic carcinomas
2017
Background This study aimed to compare the histological and immunohistochemical characteristics of ameloblastomas (AM) and ameloblastic carcinomas (AC). Material and Methods Fifteen cases of AM and 9 AC were submitted to hematoxilin and eosin (H&E) and immunohistochemical analysis with the following antibodies: cytokeratins 5,7,8,14 and 19, Ki-67, p53, p63 and the cellular adhesion molecules CD138 (Syndecan-1), E-cadherin and β-catenin. The mean score of the expression of Ki-67 and p53 labelling index (LIs) were compared between the groups using the t test. A value of p<0.05 was considered to be statistically significant. Results All cases were positive for CKs 5, 14 and 19, but negative fo…
HPLC/HRMS and GC/MS for Triacylglycerols Characterization of Tuna Fish Oils Obtained from Green Extraction
2023
Background: Fish oil is one of the most common lipidic substances that is consumed as a dietary supplement. The high omega-3 fatty acid content in fish oil is responsible for its numerous health benefits. Fish species such as mackerel, herring, tuna, and salmon are particularly rich in these lipids, which contain two essential omega-3 fatty acids, known as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Objectives: Due to the scarcity of information in the literature, this study aimed to conduct a qualitative and quantitative characterization of triglycerides (TAGs) in crude tuna fish oil using HPLC/HRMS. Fatty acid (FA) determination was also performed using GC/MS. The tuna fis…
Unsupervised network intrusion detection systems for zero-day fast-spreading network attacks and botnets
2015
Today, the occurrence of zero-day and complex attacks in high-speed networks is increasingly common due to the high number vulnerabilities in the cyber world. As a result, intrusions become more sophisticated and fast to detrimental the networks and hosts. Due to these reasons real-time monitoring, processing and intrusion detection are now among the key features of NIDS. Traditional types of intrusion detection systems such as signature base IDS are not able detect intrusions with new and complex strategies. Now days, automatic traffic analysis and anomaly intrusion detection became more efficient in field of network security however they suffer from high number of false alarms. Among all …
Planning, implementing and evaluating social and emotional skills course for coaches
2015
ABSTRACT Antell, Sanna. 2015. Planning, implementing and evaluating social and emotional skills course for coaches. Master’s Thesis in Sport and Exercise Psychology. Department of Sport Sciences. University of Jyväskylä. 79 pages. Research on Social and Emotional Skills among sport coaches is limited. Therefore, the purpose of this study was to plan, implement and evaluate a course in Social and Emotional Skills for sport coaches and instructors. The aim was to study the learning processes and the experiences of the participants. Traditionally coaches in martial arts lead with an authoritarian style; consequently the aim of this course was to show a different way of interacting with trainee…
Associations Between Adolescents' Subjectively Experienced Emotions and Psychophysiological Reactions in Achievement Situations
2022
This study investigated associations of early adolescents' (N=190, median age = 12) subjectively experienced emotions and psychophysiological reactions in achievement situations. Self-reported questions assessed adolescents' experienced emotions. Additionally, adolescents' autonomic nervous system (ANS) reactions were recorded; skin-conductance response (SCR) and heart rate (HR) were used to measure sympathetic nervous system activity, and heart rate variability (HRV) was used to measure parasympathetic nervous system activity. The between-person-level results of multilevel modeling showed that increased HR was associated with higher levels of hope and fear and that decreased SCR was associ…
Tuotehallinnan ja laajuudenhallinnan käytännöt pienessä ohjelmistoyrityksessä : tapaustutkimus
2017
Yhä useammin ohjelmistotuotetta tarjotaan avoimille markkinoille pikemminkin kuin yhdelle tietylle asiakkaalle. On myös olemassa runsaasti pieniä yrityksiä, jotka tekevät tätä ns. markkinalähtöistä ohjelmistokehitystä. Pienetkin yritykset haluavat hoitaa liiketoimintaansa ja johtaa prosessejaan menestyksekkäästi, mutta niiden kohtaamiin ongelmiin eivät suurille yrityksille tarkoitetut prosessienhallintamenetelmät sovi kovinkaan hyvin. Tämä tapaustutki-mus pyrkii löytämään kirjallisuudessa esitettyjä ratkaisuja pienen ohjelmisto-talon ongelmiin tuotteidensa ylläpidossa ja kehittämisessä. Yhtenä ratkaisuna esitellään sopiva tuotehallinnan viitekehys. Ohjelmistokehitysprojektien suurin ongelma…
Dall’analisi di contesto alle immagini di sviluppo dei distretti relazionali
2004
Il contributo degli autori mira alla definizione di una tipologia innovativa di turismo basata sulla centralità dell'interazione umana nel rapporto tra viaggiatore ed ospitante. Nel saggio è presente la descrizione della situazione siciliana nel quadro delle trasformazioni dello scenario economico e sociale del Mediterraneo. Il turismo relazionale integrato viene declinato come un modo di analizzare e valorizzare il turismo sostenibile di piccola dimensione che può essere diffuso nei territori deboli come una nuova forma di presidio umano contro l'abbandono e quindi contro il degrado ambientale.