Search results for "NEOPLASIA"

showing 10 items of 177 documents

Risk Profiles and Penetrance Estimations in Multiple Endocrine Neoplasia Type 2A Caused by Germline RET Mutations Located in Exon 10

2010

Multiple endocrine neoplasia type 2 is characterized by germline mutations in RET. For exon 10, comprehensive molecular and corresponding phenotypic data are scarce. The International RET Exon 10 Consortium, comprising 27 centers from 15 countries, analyzed patients with RET exon 10 mutations for clinical-risk profiles. Presentation, age-dependent penetrance, and stage at presentation of medullary thyroid carcinoma (MTC), pheochromocytoma, and hyperparathyroidism were studied. A total of 340 subjects from 103 families, age 4-86, were registered. There were 21 distinct single nucleotide germline mutations located in codons 609 (45 subjects), 611 (50), 618 (94), and 620 (151). MTC was present…

MalePHEOCHROMOCYTOMAendocrine system diseasesMEDULLARY-THYROID CARCINOMAAdrenal Gland NeoplasmsMultiple Endocrine Neoplasia Type 2aPenetrancemedicine.disease_causePHENOTYPEGermlineExon0302 clinical medicinemedullary thyroid carcinomaMEN2BMEN2AChildGenetics (clinical)GeneticsAged 80 and overMutationHyperparathyroidismLife SciencesExonsMiddle AgedCARRIERSPenetranceCANCERPROPHYLACTIC THYROIDECTOMY3. Good healthgenotype-phenotypeFAMILYMEN2030220 oncology & carcinogenesisChild PreschoolFemaleAdultAdolescent030209 endocrinology & metabolismMultiple endocrine neoplasia type 2BiologyPheochromocytoma03 medical and health sciencesYoung AdultGermline mutationGeneticsmedicineHumansThyroid NeoplasmsCodonGerm-Line MutationAgedNeoplasm StagingProto-Oncogene Proteins c-retCancerHIRSCHSPRUNG-DISEASEPROTOONCOGENEmedicine.diseaseGENECarcinoma NeuroendocrineCancer researchRETHuman Mutation
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Serum vitamin D levels of patients with oral squamous cell carcinoma (OSCC) and expression of vitamin D receptor in oral precancerous lesions and OSCC

2015

Background: Resistance to programmed cell death (apoptosis) is a crucial factor for the carcinogenesis of oral squamous cell carcinoma (OSCC). Vitamin D (calcitriol) may overcome apoptosis resistance in tumor cells of OSCC. Vitamin D receptor (VDR) expression in oral precancerous lesions of OSCC has not been analyzed and serum vitamin D level seems to be a predictor of cancer development. Material and Methods: Expression of VDR was analyzed in normal oral mucosa (n=5), oral precursor lesions (simple hyperplasia, n=11; squamous intraepithelial neoplasia, SIN I-III, n=35), and OSCC specimen (n=42) by immunohistochemistry (IHC). Moreover, serum vitamin D levels were measured by 25(OH)D3 (calci…

MalePathologymedicine.medical_specialtyCalcitriolOdontologíaCalcitriol receptorvitamin D deficiencymedicineCarcinomaVitamin D and neurologyHumansVitamin DGeneral DentistryRetrospective StudiesMouth neoplasmIntraepithelial neoplasiaOral Medicine and Pathologybusiness.industryResearchHyperplasiamedicine.disease:CIENCIAS MÉDICAS [UNESCO]Ciencias de la saludstomatognathic diseasesOtorhinolaryngologyUNESCO::CIENCIAS MÉDICASCancer researchCarcinoma Squamous CellReceptors CalcitriolSurgeryFemaleMouth NeoplasmsbusinessPrecancerous Conditionsmedicine.drug
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Is hospital discharge administrative data an appropriate source of information for cancer registries purposes? Some insights from four Spanish regist…

2010

Abstract Background The use of hospital discharge administrative data (HDAD) has been recommended for automating, improving, even substituting, population-based cancer registries. The frequency of false positive and false negative cases recommends local validation. Methods The aim of this study was to detect newly diagnosed, false positive and false negative cases of cancer from hospital discharge claims, using four Spanish population-based cancer registries as the gold standard. Prostate cancer was used as a case study. Results A total of 2286 incident cases of prostate cancer registered in 2000 were used for validation. In the most sensitive algorithm (that using five diagnostic codes), e…

MalePathologymedicine.medical_specialtyPediatricsNeoplasias de la próstataEspañaPopulationMEDLINESensitivity and SpecificityHealth administration:Diseases::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms Male::Prostatic Neoplasms [Medical Subject Headings]Prostate cancer:Publication Characteristics::Study Characteristics::Validation Studies [Medical Subject Headings]Research articlemedicineHumansRegistros de hospitalesRegistries:Publication Characteristics::Study Characteristics::Case Reports [Medical Subject Headings]Medical diagnosisDiagnostic Errorseducation:Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Data Collection::Registries [Medical Subject Headings]:Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings]education.field_of_studybusiness.industryHealth Policylcsh:Public aspects of medicineCancerProstatic Neoplasms:Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Data Collection::Records as Topic::Medical Records::Medical Record Linkage [Medical Subject Headings]lcsh:RA1-1270Gold standard (test)medicine.diseaseHospital RecordsPatient DischargeEstudios de validaciónSpainPopulation SurveillanceSistema de registrosDiagnosis codeForms and Records ControlMedical Record LinkageRegistro médico oordinado:Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Data Collection::Records as Topic::Medical Records [Medical Subject Headings]businessAlgorithmsBMC Health Services Research
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Reelin expression in human prostate cancer: a marker of tumor aggressiveness based on correlation with grade

2007

Reelin is a glycoprotein that plays a critical role in the regulation of neuronal migration during brain development and, since reelin has a role in the control of cell migration, it might represents an important factor in cancer pathology. In this study, 66 surgical specimens of prostate cancer were analyzed for reelin expression by immunohistochemical method. The reelin expression was correlated with Gleason score and individual Gleason patterns. Reelin expression was found in 39% prostate cancers. Stromal tissues, normal epithelial cells and prostate intraepithelial neoplasia (PIN) of any grade around and distant from cancer were always negative for reelin. Reelin was found in malignant …

MalePathologymedicine.medical_specialtyStromal cellCell Adhesion Molecules NeuronalNerve Tissue Proteinsurologic and male genital diseasesGleason Score 6Pathology and Forensic MedicineProstate cancerProstatereelinBiomarkers TumorcancerMedicineHumansReelinGleason scoreneoplasmsAgedAged 80 and overIntraepithelial neoplasiaExtracellular Matrix Proteinsprostatebiologybusiness.industrySerine EndopeptidasesCancerProstatic NeoplasmsMiddle Agedmedicine.diseaseImmunohistochemistryReelin Proteinsurgical procedures operativemedicine.anatomical_structurenervous systembiology.proteinImmunohistochemistrybusiness
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Immunohistochemical evaluation of PCNA, p53, HSP60, HSP10 and MUC-2 presence and expression in prostate carcinogenesis

2003

Background: The study of the expression of different biological markers in non-neoplastic, pre-neoplastic and neoplastic lesions of prostate could help to better understand their role in carcinogenesis and to find new diagnostic and prognostic tools. Materials and Methods: In the present work we evaluated, by immunohistochemistry, the presence and the expression of PCNA, p53, HSP60, HSP10 and MUC-2 in a series of nodular hyperplasia, low- and high-grade prostatic intraepithelial lesions and adenocarcinomas. Results: Our data confirmed that: 1) PCNA expression could be related to the grade of progression of cancer; and that 2) p53 mutation could be a late event in prostate carcinogenesis. Mo…

MaleProstatic Intraepithelial NeoplasiaMucin-2Cancer ResearchGene Expression ProfilingMucinsProstatic HyperplasiaProstateProstatic NeoplasmsCarcinogenesis; Heat-shock proteins; Prostate; Cancer Research; OncologyCell DifferentiationChaperonin 60AdenocarcinomaGenes p53ImmunohistochemistryNeoplasm ProteinsHeat-shock proteinCell Transformation NeoplasticOncologyProliferating Cell Nuclear AntigenChaperonin 10Disease ProgressionHumansTumor Suppressor Protein p53Carcinogenesi
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Clinical intervals and diagnostic characteristics in a cohort of prostate cancer patients in Spain: a multicentre observational study

2015

BACKGROUND: Little is known about the healthcare process for patients with prostate cancer, mainly because hospital-based data are not routinely published. The main objective of this study was to determine the clinical characteristics of prostate cancer patients, the, diagnostic process and the factors that might influence intervals from consultation to diagnosis and from diagnosis to treatment. METHODS: We conducted a multicentre, cohort study in seven hospitals in Spain. Patients' characteristics and diagnostic and therapeutic variables were obtained from hospital records and patients' structured interviews from October 2010 to September 2011. We used a multilevel logistic regression mode…

MalePròstata -- Càncer -- DiagnosiEspaña:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Cohort StudiesProstate cancerInterquartile rangePrevalence:Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms Glandular and Epithelial::Carcinoma::Adenocarcinoma [Medical Subject Headings]UrologiaStage (cooking)MasculinoProspective cohort studyEarly Detection of Cancer:Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Neoplasm Grading [Medical Subject Headings]General MedicineHumanosCohortCritical PathwaysMale urogenital diseasesEducational StatusProstatic neoplasmsCohort studyCohort studyEmploymentmedicine.medical_specialtyUrology:Check Tags::Male [Medical Subject Headings]Clasificación del TumorNeoplasias de la PróstataAdenocarcinomaMulticentre studyTime-to-Treatment:Diseases::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms Male::Prostatic Neoplasms [Medical Subject Headings]Age DistributionInternal medicinemedicineHumansProspective studyAgedGynecologybusiness.industryResearchMale urogenital diseasesCancerProstatic NeoplasmsOdds ratiomedicine.diseaseReproductive MedicineSpainbusiness
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Bladder cancer index: cross-cultural adaptation into Spanish and psychometric evaluation.

2014

Background: The Bladder Cancer Index (BCI) is so far the only instrument applicable across all bladder cancer patients, independent of tumor infiltration or treatment applied. We developed a Spanish version of the BCI, and assessed its acceptability and metric properties. Methods: For the adaptation into Spanish we used the forward and back-translation method, expert panels, and cognitive debriefing patient interviews. For the assessment of metric properties we used data from 197 bladder cancer patients from a multi-center prospective study. The Spanish BCI and the SF-36 Health Survey were self-administered before and 12 months after treatment. Reliability was estimated by Cronbach’s alpha.…

MalePsychometricsAparell urinariSurveys and QuestionnairesProspective cohort studyCàncermedia_commonLanguageCognitionGeneral MedicinePatient outcomeControl de qualitatNeoplasias de la Vejiga UrinariaEstudios de ValidaciónPsicometríaBufeta -- CàncerFemalePsicometriaClinical psychologyCross-Cultural ComparisonQuality of lifemedicine.medical_specialtyPsychometricsUrinary bladder neoplasms:Psychiatry and Psychology::Behavioral Disciplines and Activities::Psychological Tests::Psychometrics [Medical Subject Headings]:Publication Characteristics::Study Characteristics::Validation Studies [Medical Subject Headings]Cronbach's alpha:Disciplines and Occupations::Social Sciences::Quality of Life [Medical Subject Headings]medicine:Diseases::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Urologic Neoplasms::Urinary Bladder Neoplasms [Medical Subject Headings]media_common.cataloged_instanceHumansEuropean UnionEuropean unionAgedNeoplasm StagingGynecologyAnalysis of VarianceBladder cancerbusiness.industryResearchPublic Health Environmental and Occupational HealthConstruct validityTranslatingmedicine.diseaseCross-cultural studiesUnited StatesValidation studiesPatient outcomesCalidad de VidabusinessHealth and quality of life outcomes
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Preliminary experience on safety of regorafenib after sorafenib failure in recurrent hepatocellular carcinoma after liver transplantation

2019

Regorafenib is one option for second-line treatment of hepatocellular carcinoma (HCC), improving overall survival (OS) of sorafenib-tolerant patients who develop progression. We aim to evaluate the safety and outcomes of regorafenib as second-line treatment for HCC recurrence after liver transplantation (LT). This is a retrospective, multicenter, international study including regorafenib-treated LT patients (2015-2018), with analysis of baseline characteristics and evolutionary events during sorafenib/regorafenib treatment. Twenty-eight LT patients (57 years, 7% cirrhotics, 54% performance status 1) were included. Median time from LT to regorafenib initiation was 3.9 (1.1-18.5) years; media…

MalePyridinesmedicine.medical_treatment030230 surgeryLiver transplantationchemotherapyGastroenterologychemistry.chemical_compound0302 clinical medicineAntineoplastic Combined Chemotherapy ProtocolsImmunology and AllergyPharmacology (medical)Liver NeoplasmsMiddle AgedSorafenibPrognosisRecurrent Hepatocellular Carcinomaside effectsHepatocellular carcinomaFemalemedicine.drugSorafenibAdultmedicine.medical_specialtyCarcinoma Hepatocellularcancer/malignancy/neoplasiaclinical research/practice03 medical and health sciencesYoung AdultInternal medicineRegorafenibmedicineHumansAdverse effectAgedRetrospective StudiesTransplantationdrug interactionPerformance statusbusiness.industryPhenylurea Compoundsmedicine.diseaseDiscontinuationLiver TransplantationchemistryDrug Resistance NeoplasmNeoplasm Recurrence Localpharmacologybusinessliver transplantation/hepatologyFollow-Up Studies
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Cancer mortality inequalities in urban areas: a Bayesian small area analysis in Spanish cities

2011

incluye "Erratum to: Cancer mortality inequalities in urban areas: a Bayesian small area analysis in Spanish cities" BACKGROUND: Intra-urban inequalities in mortality have been infrequently analysed in European contexts. The aim of the present study was to analyse patterns of cancer mortality and their relationship with socioeconomic deprivation in small areas in 11 Spanish cities. METHODS: It is a cross-sectional ecological design using mortality data (years 1996-2003). Units of analysis were the census tracts. A deprivation index was calculated for each census tract. In order to control the variability in estimating the risk of dying we used Bayesian models. We present the RR of the censu…

MaleUrban PopulationEstudios transversalesCross-sectional studyEspaña:Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings]Business Management and Accounting(all)Disparidades en el estado de saludPoblación urbanaHealth informatics:Health Care::Population Characteristics::Population::Urban Population [Medical Subject Headings]NeoplasmsHuman geographyEpidemiologyCàncerUrban areasSocioeconomicsSmall-Area Analysismedia_common:Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings]Geography:Diseases::Neoplasms [Medical Subject Headings]CensusNeoplasiasGeography:Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Statistics as Topic::Probability::Bayes Theorem [Medical Subject Headings]lcsh:R858-859.7EnfermeríaFemaleRisk assessmentComputer Science(all)Riskmedicine.medical_specialtyGeneral Computer ScienceInequalitymedia_common.quotation_subjectHealth geographyeducationBayesian probabilityMedi ambientCancer mortalitylcsh:Computer applications to medicine. Medical informaticsRisk AssessmentCàncer -- MortalitatCiutatsMortalitatmedicineConfidence IntervalsTeorema de BayesHumansCancer -- MortalitySocioeconomic statusPovertyPovertybusiness.industryPublic healthResearchPublic Health Environmental and Occupational HealthCorrection:Health Care::Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Health Status::Health Status Disparities [Medical Subject Headings]Bayes TheoremHealth Status DisparitiesGeneral Business Management and AccountingSocioeconomic deprivationBayesian statistical decisionCross-Sectional StudiesEstadística bayesianaSocioeconomic FactorsSpainInequalitiesbusinessDemographyInternational Journal of Health Geographics
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Prospective evaluation of the macroscopic types and location of early Barrett’s neoplasia in 380 lesions

2007

The macroscopic appearance of early gastric cancers, classified according to the Japanese criteria, has been shown to be an important prognostic factor for local endoscopic therapy. No prospective data about the distribution of macroscopic types and their location in early Barrett's neoplasia are available, however. The present study was conducted to evaluate the clinical applicability of this macroscopic classification and to analyze the relative proportions of the different gross types in early Barrett's neoplasms and the correlation between the macroscopic classification and the stage or grade of differentiation.A total of 344 patients with 380 Barrett's neoplastic lesions who were refer…

Malemedicine.medical_specialtyEsophageal NeoplasmsBiopsyVideo RecordingSeverity of Illness IndexGastroenterologyEndoscopy GastrointestinalBarrett EsophagusInternal medicinemedicineCarcinomaHumansProspective StudiesIntestinal MucosaStage (cooking)EsophagusStomach cancerProspective cohort studyAgedNeoplasm StagingObserver VariationIntraepithelial neoplasiamedicine.diagnostic_testEsophageal diseasebusiness.industryGastroenterologyReproducibility of ResultsPrognosismedicine.diseaseEndoscopyEsophagectomymedicine.anatomical_structureDisease ProgressionFemalebusinessFollow-Up StudiesEndoscopy
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