Search results for "NERC"
showing 10 items of 57 documents
Fast recovery with etanercept in patients affected by polymyalgia rheumatica and decompensated diabetes: a case-series study
2008
We enrolled nine consecutive patients affected by newly diagnosed polymyalgia rheumatica and decompensated diabetes mellitus. All patients were treated with etanercept (25 mg twice weekly) and prednisone and were followed up to 1 year. At the sixth-month follow-up, etanercept and prednisone were withdrawn. Patients were seen at regular intervals (days 0, 30, 60, 90, 150, 180) and the following variables determined: erythrocytes sedimentation rate, C-reactive protein, fasting serum glucose, pain measured by visual analog scale, and the Health Assessment Questionnaire. Our results indicate that etanercept might have some steroid-sparing effects, but controlled investigations are needed to sup…
Studies of selective TNF inhibitors in the treatment of brain injury from stroke and trauma: a review of the evidence to date
2014
Antonino Tuttolomondo, Rosaria Pecoraro, Antonio Pinto Biomedical Department of Internal and Specialistic Medicine, University of Palermo, Palermo, Italy Abstract: The brain is very actively involved in immune-inflammatory processes, and the response to several trigger factors such as trauma, hemorrhage, or ischemia causes the release of active inflammatory substances such as cytokines, which are the basis of second-level damage. During brain ischemia and after brain trauma, the intrinsic inflammatory mechanisms of the brain, as well as those of the blood, are mediated by leukocytes that communicate with each other through cytokines. A neuroinflammatory cascade has been reported to be activ…
Cilvēka kustību novērošana, izmantojot inerciālos sensorus
2020
Cilvēka kustību novērošana, izmantojot inerciālos sensorus, mūsdienas ir ļoti populāra pētniecības metode, ko pielieto medicīnā, rehabilitācijā, sportā un citās nozarēs. Darbā tika izpētītas tehnoloģiskās iespējas, lai veiktu cilvēka kustību novērošanu, kā arī esošie pielietojumi cilvēka kustību novērošanai hokejā. Darba mērķis ir veikt profesionāla un entuziasta līmeņa hokejistu hokeja metienu kustību novērošanu, lai noteiktu, kura entuziasta hokeja metiens procentuāli visvairāk atbilst profesionāla hokeja metiena sasniegtajam lineārajām paātrinājumam. Novēroto datu apstrādei, tika izmantota “Python” programmēšanas valoda, ar kuru tika …
Dose adjustments and discontinuation in TNF inhibitors treated patients: when and how. A systematic review of literature.
2018
Objectives To review the available evidence concerning the possibility of discontinuing and/or tapering the dosage of TNF inhibitors (TNFi) in RA patients experiencing clinical remission or low disease activity. Methods A systematic review of the literature concerning the low dosage and discontinuation of TNFi in disease-controlled RA patients was performed by evaluation of reports published in indexed international journals (Medline via PubMed, EMBASE), in the time frame from 8 April 2013 to 15 January 2016. Results We analysed the literature evaluating the efficacy and the safety of two different strategies using TNFi, decreasing dosage or discontinuation, in patients experiencing clinica…
Evaluation of the disease course of Italian children with juvenile idiopathic arthritis treated with etanercept: preliminary results in 772 patients
2014
The advent of biologic medications has considerably increased the potential for treatment benefit in juvenile idiopathic arthritis (JIA), with clinical remission being now achievable in a substantial proportion of patients.
Efectividad de una intervención de automanejo de la hipertensión arterial en la mejora de la inercia terapéutica y la adherencia a los medicamentos a…
2021
La HTA es un reto de salud pública en términos de morbilidad y mortalidad por ictus o enfermedad cardiovascular y asociada a elevados costes sanitarios con un porcentaje bajo de control en todos los sistemas sanitarios. Tanto la falta de adherencia como la inercia terapéutica son barreras que impiden alcanzar objetivos clínicos, especialmente en patologías crónicas como la HTA, ya que están relacionadas con una insuficiente prescripción de tratamientos, pérdida de efectividad, un incremento de los costes sanitarios y aumento de las complicaciones características de la HTA. La evidencia disponible orienta hacia que el uso de intervenciones conductuales con establecimiento de objetivos compar…
AB0465 Etanercept therapy in rheumatoid arthritis patients with moderate or severe disease activity
2013
Background Rheumatoid arthritis (RA) is conventionally defined as moderate when the disease activity score assessed in 28 joints (DAS28) is ≥3.2, and high disease with DAS28 >5.1 Objectives Aim of this analysis was to evaluate the rate of remission and LDA (low disease activity), in RA patients starting etanercept therapy with moderate disease activity in the real world settings Methods The clinical records were retrospectively analysed from the Italian nationwide registry, called GISEA (Gruppo Italiano Studio Early Arthritis). RA patients with moderate (Mod-RA) and high (H-RA) disease activity (DAS28 >3.2) with incomplete response to conventional DMARDs and beginning a treatment with etane…
Levetiracetam‐induced pediatric toxic epidermal necrolysis successfully treated with etanercept
2020
Successful management of toxic epidermal necrolysis (TEN) with tumor necrosis factor-α inhibitors has been described in adults, but few cases have been reported in children. To date, only four pediatric cases of TEN treated with infliximab and one with etanercept have been published. We present the case of an 8-year-old boy diagnosed with TEN induced by levetiracetam, successfully treated with etanercept, systemic corticosteroids, and intravenous immunoglobulin.
Enseñanza de las ciencias : revista de investigación y experiencias didácticas
2006
Resumen basado en el de la publicación Resumen en inglés Se muestra el importante papel de uno de los instrumentos más comunes, el péndulo, en la construcción del paradigma newtoniano. Del análisis de algunas aplicaciones interesantes llevadas a cabo por los mejores científicos de ese tiempo, se concluye que el uso apropiado del péndulo en el aula puede ser una manera fácil de introducir la evolución histórica y epistemológica de conceptos físicos básicos. ESP
BioTIME: A database of biodiversity time series for the Anthropocene
2018
Abstract Motivation The BioTIME database contains raw data on species identities and abundances in ecological assemblages through time. These data enable users to calculate temporal trends in biodiversity within and amongst assemblages using a broad range of metrics. BioTIME is being developed as a community-led open-source database of biodiversity time series. Our goal is to accelerate and facilitate quantitative analysis of temporal patterns of biodiversity in the Anthropocene. Main types of variables included The database contains 8,777,413 species abundance records, from assemblages consistently sampled for a minimum of 2 years, which need not necessarily be consecutive. In addition, th…