Search results for "NERVE"
showing 10 items of 1683 documents
The cyclopentenone-type prostaglandin 15-deoxy-delta12,14-prostaglandin J2 inhibits CD95 ligand gene expression in T lymphocytes: interference with p…
2003
Abstract 15-Deoxy-Δ12,14-PGJ2 (15d-PGJ2) is a cyclopentenone-type PG endowed with anti-inflammatory properties and produced by different cells, including those of the immune system. 15d-PGJ2 is a natural ligand of the peroxisome proliferator-activated receptor (PPAR)-γ nuclear receptor, but relevant PPARγ-independent actions mediated by this prostanoid have been described. Fas (APO-1/CD95) and its ligand (Fas-L) are cell surface proteins whose interaction activates apoptosis of Fas-expressing targets. In T cells, the Fas-Fas-L system regulates activation-induced cell death and has been implicated in diseases in which lymphocyte homeostasis is compromised. Moreover, several studies have desc…
Assessing causality in brain dynamics and cardiovascular control
2013
Understanding how different cerebral areas interact to produce an integrated behaviour and disentangling the mechanisms that contribute to cardiovascular control are two of the major challenges of brain and cardiovascular neuroscience. The increasing availability of simultaneous continuous
Prenatal diazepam exposure functionally alters the GABA(A) receptor that modulates [3H]noradrenaline release from rat hippocampal synaptosomes.
2002
In rats, exposure to diazepam (DZ) during the last week of gestation is associated with behavioral alterations (in some cases sexually dimorphic) that appear when the animals reach adulthood. This study was conducted to evaluate the effects of prenatal DZ exposure on the function of the gamma-aminobutyric (GABA)(A) receptor complex. The method used - perfusion of rat hippocampal nerve terminals labeled with [3H]noradrenaline (NA) - allowed us to evaluate the effects of DZ on a specific native GABA(A) receptor subtype which is located on hippocampal noradrenergic nerve endings and mediates the release of NA. Muscimol stimulated synaptosomal release of [3H]NA in a concentration-dependent mann…
Laparoscopic endopelvic sacral implantation of a Brindley controller for recovery of bladder function in a paralyzed patient
2008
Background: A number of techniques are being investigated to accomplish bladder control recovery in paralyzed patients using the neurostimulation, but currently, all techniques are based on the dorsal implantation of the electrodes using a laminectomy. Methods: On 27 April 2006 we performed a laparoscopic implantation of a Finetech-Brindley bladder controller on the endopelvic sacral roots in a Th8 completely paralyzed woman who had previously undergone the removal of a Brindley controller due to an arachnoiditis after extrathecal implantation with intradural sacral deafferentation. Results: We required about 3.5 h for the entire surgical procedure; no complications occurred and the patient…
Mechanisms of protein expression in the rat optic nerve: Modifications by alcohol exposure
2005
espanolObjetivos: Nuestros trabajos previos han demostrado que el consumo abusivo de etanol durante la gestacion induce retraso en el desarrollo y alteraciones estructurales en los ojos y en la vision (Pinazo-Duran et al., Teratology 93; Eur J Ophthalmol 97; Stromland and Pinazo-Duran, Teratology 94; Alcohol Alcoholism 02). Nos proponemos estudiar a un nivel celular y molecular si el etanol modifica la expresion de proteinas marcadoras del desarrollo glial durante los estadios pre- y postnatal de la rata, que puedan contribuir a la dismorfogenesis del nervio optico. Metodo: Para estudiar las acciones del etanol sobre el desarrollo del nervio optico de ratas sometidas a un proceso de alc…
Charcot-Marie-Tooth disease: Genetic and clinical spectrum in a Spanish clinical series
2013
Objectives: To determine the genetic distribution and the phenotypic correlation of an extensive series of patients with Charcot-Marie-Tooth disease in a geographically well-defined Mediterranean area. Methods: A thorough genetic screening, including most of the known genes involved in this disease, was performed and analyzed in this longitudinal descriptive study. Clinical data were analyzed and compared among the genetic subgroups. Results: Molecular diagnosis was accomplished in 365 of 438 patients (83.3%), with a higher success rate in demyelinating forms of the disease. The CMT1A duplication (PMP22 gene) was the most frequent genetic diagnosis (50.4%), followed by mutations in the GJB1…
Tissue Sparing Posterior Cervical Indirect Decompression and Fusion in Foraminal Stenosis
2016
Treatment for patients with cervical foraminal stenosis that present with cervical radiculopathy has experienced rapid progress. Cervical spine surgical options have improved through advances in imaging, instrumentation, implant innovations and novel surgical techniques. While historical treatments are largely safe, comorbidities associated with procedures such as ACDF, TDR, and posterior foraminotomy beg the question if these procedures are too much surgery for select patients that could benefit from a tissue sparing approach. This chapter will introduce a novel, less disruptive surgical technique for achieving indirect decompression and fusion utilizing an intervertebral cervical implant.…
The influence of eye movements on the temporal features of executed and imagined arm movements.
2007
The very close coordination between eye and hand indicates that eye movements are parts of the neural processes underlying the planning and control of arm movements. Eye movements are fundamental during observed actions and play a functional role in visual mental imagery. However, the role of eye movements during imagined actions is still unknown. Here, we report the timing features of eye and arm pointing movements for nine healthy participants in four conditions: Executed movements with orientation saccades (Eyes Free) or with no saccades (Eyes Motionless), and Imagined movements with Eyes Free or with Eyes Motionless. The first result was a facilitation effect of saccades upon both execu…
Ephaptic coupling of myelinated nerve fibers
2001
Numerical predictions of a simple myelinated nerve fiber model are compared with theoretical results in the continuum and discrete limits, clarifying the nature of the conduction process on an isolated nerve axon. Since myelinated nerve fibers are often arranged in bundles, this model is used to study ephaptic (nonsynaptic) interactions between impulses on parallel fibers, which may play a functional role in neural processing.