Search results for "NETWORKS"
showing 10 items of 3260 documents
Inducible and reversible inhibition of mirna-mediated gene repression in vivo
2021
Although virtually all gene networks are predicted to be controlled by miRNAs, the contribution of this important layer of gene regulation to tissue homeostasis in adult animals remains unclear. Gain and loss-of-function experiments have provided key insights into the specific function of individual miRNAs, but effective genetic tools to study the functional consequences of global inhibition of miRNA activity in vivo are lacking. Here we report the generation and characterization of a genetically engineered mouse strain in which miRNA-mediated gene repression can be reversibly inhibited without affecting miRNA biogenesis or abundance. We demonstrate the usefulness of this strategy by invest…
Longevity: epigenetic and biomolecular aspects
2015
AbstractMany aging theories and their related molecular mechanisms have been proposed. Simple model organisms such as yeasts, worms, fruit flies and others have massively contributed to their clarification, and many genes and pathways have been associated with longevity regulation. Among them, insulin/IGF-1 plays a key and evolutionary conserved role. Interestingly, dietary interventions can modulate this pathway. Calorie restriction (CR), intermittent fasting, and protein and amino acid restriction prolong the lifespan of mammals by IGF-1 regulation. However, some recent findings support the hypothesis that the long-term effects of diet also involve epigenetic mechanisms. In this review, w…
ROS/Gazebo-Based Simulation of Quadcopter Aircrafts
2018
The main purpose of this work is to present a tutorial description on how to design and develop an observer, which is capable of estimating the position and the orientation of a drone commanded by a controller, whose shape and structure are unknown. Starting from Newton's and Euler's laws, a mathematical model describing the dynamics of a quadcopter has first been obtained. By linearizing this model it is possible to implement a Luenberger observer and validate it with simulations in a Linux environment, thanks to the use of the Ardupilot controller and the Gazebo simulator. Finally, starting from the results obtained from the simulation, it is possible to evaluate the error made in the est…
On the accurate determination of nonisolated solutions of nonlinear equations
1981
A simple but efficient method to obtain accurate solutions of a system of nonlinear equations with a singular Jacobian at the solution is presented. This is achieved by enlarging the system to a higher dimensional one whose solution in question is isolated. Thus it can be computed e. g. by Newton's method, which is locally at least quadratically convergent and selfcorrecting, so that high accuracy is attainable.
A 21st century technique for food control: electronic noses.
2008
This work examines the main features of modern electronic noses (e-noses) and their most important applications in food control in this new century. The three components of an electronic nose (sample handling system, detection system, and data processing system) are described. Special attention is devoted to the promising mass spectrometry based e-noses, due to their advantages over the more classical gas sensors. Applications described include process monitoring, shelf-life investigation, freshness evaluation, authenticity assessment, as well as other general aspects of the utilization of electronic noses in food control. Finally, some interesting remarks concerning the strengths and weakn…
Factors that influence the quality of metabolomics data in in vitro cell toxicity studies: a systematic survey
2021
Abstract REACH (Registration, Evaluation, Authorization and Restriction of Chemicals) is a global strategy and regulation policy of the EU that aims to improve the protection of human health and the environment through the better and earlier identification of the intrinsic properties of chemical substances. It entered into force on 1st June 2007 (EC 1907/2006). REACH and EU policies plead for the use of robust high-throughput "omic" techniques for the in vitro investigation of the toxicity of chemicals that can provide an estimation of their hazards as well as information regarding the underlying mechanisms of toxicity. In agreement with the 3R’s principles, cultured cells are nowadays wide…
Quality System for Production Software as Tool for Monitoring and Improving Organization KPIs
2013
In this paper we propose a solution as support for quality systems for production software. The motivation behind this study was to reduce that cost in the production area caused by gaps in the quality of the production software. Our proposal: QSPS (Quality System for Production Software) is offering support in the "vulnerable points" of these quality systems which usually generate nonconformities and have proved to be difficult or impossible to control. QSPS is a method in seven steps or modules that integrates also software tools, templates, checklists, evaluating tools elaborated complying to products, process and system quality standards. If other analyzed methods like: Scrum, XP, Fuzzy…
Energy-Efficiency and Coverage Quality Management for Reliable Diagnostics in Wireless Sensor Networks
2020
International audience; The processing of data and signals provided by sensors aims at extracting rnrelevant features which can be used to assess and diagnose the health state rnof the monitored targets. Nevertheless, Wireless Sensor Networks (WSNs) present rna number of shortcomings that have an impact on the quality of the gathered rndata at the sink level, leading to imprecise diagnostics rnof the observed targets. To improve data accuracy, two main critical and related issues, namely the energy consumption and coverage quality, need to be considered. The goal is to maximize the network lifetime while guaranteeing the complete coverage of all the targets. Unfortunately, these performance…
Transition structures for hydride transfer reactions in vacuo and their role in enzyme catalysis
1996
A general discussion as to the role of in vacuo transition structure in enzyme catalysis is presented. Quantum mechanical aspects are emphasized. The transition structures defined as saddle points ...
Elastic properties of DNA linked flexible magnetic filaments.
2011
Elastic properties of magnetic filaments linked by DNA in solutions of univalent and bivalent salts with different pH values are investigated through their deformation in an external field. A strong dependence of the bending modulus in bivalent salt solution on the pH is shown. Experimental results are interpreted on the basis of the magnetic elastica.