Search results for "NEUROBIOLOGY"
showing 5 items of 125 documents
Sense and Antisense DMPK RNA Foci Accumulate in DM1 Tissues during Development.
2015
International audience; Myotonic dystrophy type 1 (DM1) is caused by an unstable expanded CTG repeat located within the DMPK gene 3'UTR. The nature, severity and age at onset of DM1 symptoms are very variable in patients. Different forms of the disease are described, among which the congenital form (CDM) is the most severe. Molecular mechanisms of DM1 are well characterized for the adult form and involve accumulation of mutant DMPK RNA forming foci in the nucleus. These RNA foci sequester proteins from the MBNL family and deregulate CELF proteins. These proteins are involved in many cellular mechanisms such as alternative splicing, transcriptional, translational and post-translational regul…
Toward a link between brain plasticity and satiety
2021
International audience
Role of acetaldehyde in alcohol addiction: current evidence and future perspectives
2011
The effects of alcohol have been widely studied during the past century, corroborating the idea that this tiny chemical compound acts throughout most of our neurotransmitter systems since it is capable of inducing addictive behaviour. Two of the most serious problems of alcohol addiction are craving and relapse; several studies have demonstrated that relapse is related to the anxious state which occurs during withdrawal, and it has been proved that this behavioural modifications results from an alteration of the dopaminergic and serotonergic systems. An important role in the neurobiology of alcohol addiction is played by acetaldehyde (ACD), ethanol first metabolite. Our recent studies indee…
Holographical Concept of Reality – a Unifying Theory for Physics, Neurobiology and Philosophy
2016
The aim of this article is to introduce readers to holographic concept of reality shared by different fields of science. It may show, that understanding the world around us is a task beyond our comprehension dues to its multi-level structure. Is it possible to learn about holographical reality with our limited human mind which itself could be a multi-dimensional hologram?