Search results for "NEUROSCIENCE"
showing 10 items of 8040 documents
Fractalkine Signaling and Microglia Functions in the Developing Brain.
2015
Microglial cells are the resident macrophages of the central nervous system (CNS). Besides their classical roles in pathological conditions, these immune cells also dynamically interact with neurons and influence their structure and function in physiological conditions. The neuronal chemokine fractalkine and its microglial receptor CX3CR1 are one important signaling pathway involved in these reciprocal interactions. In the present review, we will discuss recent evidence indicating that fractalkine signaling also determines several functions of microglial cells during normal CNS development. It has been known for a decade that microglial cells influence the neuronal death that normally occur…
Enkephalin-containing interneurons are specialized to innervate other interneurons in the hippocampal CA1 region of the rat and guinea-pig
1998
Enkephalins are known to have a profound effect on hippocampal inhibition, but the possible endogenous source of these neuropeptides, and their relationship to inhibitory interneurons is still to be identified. In the present study we analysed the morphological characteristics of met-enkephalin-immunoreactive cells in the CA1 region of the rat and guinea-pig hippocampus, their coexistence with other neuronal markers and their target selectivity at the light and electron microscopic levels. Several interneurons in all subfields of the hippocampus were found to be immunoreactive for met-enkephalin. In the guinea-pig, fibres arising from immunoreactive interneurons were seen to form a plexus …
Radial glial fibers support neuronal migration and regeneration after neonatal brain injury. Jinnou et al
2018
Catwalk raw data related to Figure 4 in "Radial glial fibers support neuronal migration and regeneration after neonatal brain injury" Jinnou et al., 2018, Cell Stem Cell 22, 128–137.
The Impact of Single-Level ACDF on Neural Foramen and Disc Height of Surgical and Adjacent Cervical Segments: A Case-Series Radiological Analysis
2023
Background: ACDF has become one of the established procedures for the surgical treatment of symptomatic cervical spondylosis, showing excellent clinical results and effective improvements in neural functions and neck pain relief. The main purpose of ACDF is neural decompression, and it is considered by some authors as an indirect result of the intervertebral distraction and cage insertion and the consequent restoration of the disc space and foramen height. Methods: Radiological data from 28 patients who underwent single-level ACDF were retrospectively collected and evaluated. For neural foramen evaluation, antero-posterior (A-P) and cranio-caudal (C-C) diameters were manually calculated; fo…
Hyper-flexible Convolutional Neural Networks based on Generalized Lehmer and Power Means
2022
Convolutional Neural Network is one of the famous members of the deep learning family of neural network architectures, which is used for many purposes, including image classification. In spite of the wide adoption, such networks are known to be highly tuned to the training data (samples representing a particular problem), and they are poorly reusable to address new problems. One way to change this would be, in addition to trainable weights, to apply trainable parameters of the mathematical functions, which simulate various neural computations within such networks. In this way, we may distinguish between the narrowly focused task-specific parameters (weights) and more generic capability-spec…
The Integration of Social and Neural Synchrony : A Case for Ecologically-Valid Research Using MEG Neuroimaging
2021
The recent decade has seen a shift from artificial and environmentally-deprived experiments in neuroscience to real-life studies on multiple brains in interaction, coordination and synchrony. In these new interpersonal synchrony experiments, there has been a growing trend to employ naturalistic social interactions to evaluate mechanisms underlying synchronous neuronal communication. Here, we emphasize the importance of integrating the assessment of neural synchrony with measurement of non-verbal behavioral synchrony as expressed in various social contexts: relaxed social interactions, planning a joint pleasurable activity, conflict discussion, invocation of trauma, or support giving, and as…
La ciència com a cerca. Don Quixot, la neurociència i l'interrogatori de la veritat
2014
El neurocientifi c Rodrigo Quian Quiroga es va preguntar si «els cientifi cs, embarcats en cerques personals i quixotesques croades, es passen el temps pensant». Aquesta invocacio adjectival del Quixot de Cervantes presenta la ciencia com una cerca epica que equipara la racionalitat cientifi ca amb els deliris de Don Quixot. Es la cerca de la veritat per part de la ciencia, quixotesca i literaria, un «racionalisme neurotic», en paraules del fi losof Nicholas Maxwell?
Validation of a Psychosocial Chronic Stress Model in the Pig Using a Multidisciplinary Approach at the Gut-Brain and Behavior Levels
2019
Psychological chronic stress is an important risk factor for major depressive disorder, of which consequences have been widely studied in rodent models. This work aimed at describing a pig model of chronic stress based on social isolation, environmental impoverishment and unpredictability. Three groups of animals of both sexes were constituted. Two were exposed to the psychosocial stressors while receiving (SF, n = 12) or not (SC, n = 22) the antidepressant fluoxetine, and a third group (NSC, n = 22) remained unstressed. Animals were observed in home pens and during dedicated tests to assess resignation and anxiety-like behaviors. Brain structure and function were evaluated via proton MRS a…
The lizard cerebral cortex as a model to study neuronal regeneration
2002
The medial cerebral cortex of lizards, an area homologous to the hippocampal fascia dentata, shows delayed postnatal neurogenesis, i.e., cells in the medial cortex ependyma proliferate and give rise to immature neurons, which migrate to the cell layer. There, recruited neurons differentiate and give rise to zinc containing axons directed to the rest of cortical areas, thus resulting in a continuous growth of the medial cortex and its zinc-enriched axonal projection. This happens along the lizard life span, even in adult lizards, thus allowing one of their most important characteristics: neuronal regeneration. Experiments in our laboratory have shown that chemical lesion of the medial cortex…
Transcranial Magnetic Stimulation and Neuroimaging Coregistration
2013
The development of neuroimaging techniques is one of the most impressive advancements in neuroscience. The main reason for the widespread use of these instruments lies in their capacity to provide an accurate description of neural activity during a cognitive process or during rest. This important advancement is related to the possibility to selectively detect changes of neuronal activity in space and time by means of different biological markers. Specifically, functional magnetic resonance imaging (fMRI), positron emission tomography (PET), single-photon emission computed tomography (SPECT), and nearinfrared spectroscopy (NIRS) use metabolic markers of ongoing neuronal activity to provide a…