Search results for "NHE"
showing 10 items of 1058 documents
Dynamic formation of hybrid peptidic capsules by chiral self-sorting and self-assembly.
2014
Owing to their versatility and biocompatibility, peptide-based self-assembled structures constitute valuable targets for complex functional designs. It is now shown that artificial capsules based on β-barrel binding motifs can be obtained by means of dynamic covalent chemistry (DCC) and self-assembly. Short peptides (up to tetrapeptides) are reversibly attached to resorcinarene scaffolds. Peptidic capsules are thus selectively formed in either a heterochiral or a homochiral way by simultaneous and spontaneous processes, involving chiral sorting, tautomerization, diastereoselective induction of inherent chirality, and chiral self-assembly. Self-assembly is shown to direct the regioselectivit…
A comparative study between Chinese and Finns : communication accommodation and values exchange in grandparent and grandchild communication
2017
This study explores differences and similarities between grandparent-grandchild (GP-GC) communication in China and Finland. GP-GC communication and relationship has been understudied for decades since scholars in family communication domain have been focusing on relationships among other family members. The culture of the residents of China, the origin of Confucianism, is isolated from that of other East Asian nations. In view of dramatic socioeconomic development, examining how the traditional GP-GC relationship within the family has changed is valuable. On the other hand, Finland possesses a culture with contrasting traits. Characterized by individualism, Finns are prone to focus primaril…
Chitosan-phosphotungstic acid complex as membranes for low temperature H2-O2 fuel cell
2015
Abstract Free-standing Chitosan/phosphotungstic acid polyelectrolyte membranes were prepared by an easy and fast in-situ ionotropic gelation process performed at room temperature. Scanning electron microscopy was employed to study their morphological features and their thickness as a function of the chitosan concentration. The membrane was tested as proton conductor in low temperature H 2 –O 2 fuel cell allowing to get peak power densities up to 350 mW cm −2 . Electrochemical impedance measurements allowed to estimate a polyelectrolyte conductivity of 18 mS cm −1 .
Plasma non-cholesterol sterols: a useful diagnostic tool in pediatric hypercholesterolemia.
2010
Current guidelines strongly recommend the identification of genetic forms of hypercholesterolemia (HC) during childhood. The usefulness of non–cholesterol sterols (NCS) in the diagnosis of genetic HC has not been fully explored. Plasma NCS were measured by gas chromatography/mass spectrometry (GC/MS) in 113 children with hypercholesterolemia affected by: autosomal dominant hypercholesterolemia (ADH), familial combined hyperlipidemia (FCHL), polygenic hypercholesterolemia (PHC), and in 79 controls to evaluate: i) plasma NCS profile in different genetic HC and ii) the usefulness of NCS for the diagnosis of HC beyond current clinical criteria. ADH was characterized by raised lathosterol/total …
DNA methylation episignature testing improves molecular diagnosis of Mendelian chromatinopathies
2021
Abstract Purpose Chromatinopathies include more than 50 disorders caused by disease-causing variants of various components of chromatin structure and function. Many of these disorders exhibit unique genome-wide DNA methylation profiles, known as episignatures. In this study, the methylation profile of a large cohort of individuals with chromatinopathies was analyzed for episignature detection. Methods DNA methylation data was generated on extracted blood samples from 129 affected individuals with the Illumina Infinium EPIC arrays and analyzed using an established bioinformatic pipeline. Results The DNA methylation profiles matched and confirmed the sequence findings in both the discovery an…
Toward Livable City Centers. Hebron as a Case Study
2012
City centers of Palestinian cities face many urban planning problems; the downtown city is mostly crowded especially in the last few years, because of the increasing population of the cities and the daily migration of the residents from the nearby villages. Everyone can touch the traffic jam problem, the bad quality of urban spaces, the lack of gardens and open spaces in the city center. All this affects negatively the citizens of the city, feeling uncomfortable in the city center. Thus, this study comes to light to draw guidelines to create a comfortable and livable urban environment for people in the city center and to develop the city center to a more environmental, functional, beautiful…
Inheritance patterns of photoperiodic diapause induction in Leptinotarsa decemlineata
2016
Photoperiod is a reliable indicator of season and an important cue that many insects use for phenological synchronization. Undergoing range expansion insects can face a change in the local photoperiod to which they need to resynchronize. Rapid range expansion can be associated with rapid photoperiodic adaptation, which can be associated with intense selection on strongly heritable polygenic traits. Alternatively, it is proposed that, in insects with an XO sex-determination system, genes with large effect residing on the sex chromosome could drive photoperiodic adaptation because the gene or genes are exposed to selection in the sex carrying only a single X-chromosome. The present study seek…
Reverse inheritance in statically typed object-oriented programming languages
2010
Reverse inheritance is a new class reuse mechanism, an experimental implementation of which we have built for Eiffel. It enables a more natural design approach, factorization of common features (members), insertion of classes into an existing hierarchy etc. Due to its reuse potential in Eiffel we consider exploring its capabilities in other industrial-strength programming languages like C++, Java and C#.
The importance of Organizational Commitment to Knowledge Management
2008
In recent years, Knowledge Management (KM) has assumed great importance in the literature on business and management. However, we still have so little understanding of the human issues in KM processes. Thus, this research aims to contribute to analysing the importance of Organizational Commitment (OC) to KM. First, we used the Cardoso (2003) Knowledge Management Questionnaire (QGC) that embraces all organizational activities around knowledge processes and distinguishes four dimensions of KM. Secondly we applied the Quijano, Masip, Navarro and Aubert (1997) questionnaire (ASH-ICI) that distinguishes two types of commitment (personal and instrumental) into four dimensions. These two questionn…
Inherently Chiral Calixarenes
1994
Due to the nonplanarity of the basic 1 n -metacyclophane system, calixarenes and resorcarenes can be transformed into molecules with inherent chirality. Various attempts to achieve this goal are reviewed. Special emphasis is given to derivatives with C n -symmetry, including derivatives of spherand calixarenes and other calixarene-like macrocycles.