Search results for "NHL"
showing 10 items of 13 documents
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
2021
Abstract Background Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in populations has become a major goal in the field. Results Leveraging DNA methylation and SNP data from more than 40,000 individuals, we identify 137 genome-wide significant loci, of which 113 are novel, from genome-wide association study (GWAS) meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We find evidence for shared genetic loci ass…
Etiologic Heterogeneity Among Non-Hodgkin Lymphoma Subtypes: The InterLymph Non-Hodgkin Lymphoma Subtypes Project
2014
Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy and the fifth most common type of cancer in more developed regions of the world (1). Numerous NHL subtypes with distinct combinations of morphologic, immunophenotypic, genetic, and clinical features are currently recognized (2,3). The incidence of NHL subtypes varies substantially by age, sex, and race/ethnicity (4–7). However, the etiological implications of this biological, clinical, and epidemiological diversity are incompletely understood. The importance of investigating etiology by NHL subtype is clearly supported by research on immunosuppression, infections, and autoimmune diseases, which are the strongest and most e…
Rationale and Design of the International Lymphoma Epidemiology Consortium (InterLymph) Non-Hodgkin Lymphoma Subtypes Project
2014
Background: Non-Hodgkin lymphoma (NHL), the most common hematologic malignancy, consists of numerous subtypes. The etiology of NHL is incompletely understood, and increasing evidence suggests that risk factors may vary by NHL subtype. However, small numbers of cases have made investigation of subtype-specific risks challenging. The International Lymphoma Epidemiology Consortium therefore undertook the NHL Subtypes Project, an international collaborative effort to investigate the etiologies of NHL subtypes. This article describes in detail the project rationale and design. Methods: We pooled individual-level data from 20 case-control studies (17 471 NHL cases, 23 096 controls) from North Ame…
A sustainable replacement for TiO2 in photocatalyst construction materials: Hydroxyapatite-based photocatalytic additives, made from the valorisation…
2018
The use of waste materials and by-products in building materials is of increasing importance to improve sustainability in construction, as is the incorporation of photocatalytic materials to both combat atmospheric pollution and protect the structures and façades. This work reports the innovative use of photocatalytic hydroxyapatite (HAp) based powders, derived from Atlantic codfish bone wastes, as an additive to natural hydraulic lime mortars. HAp is the main component of bone, and hence is non-toxic and biocompatible. This is the first time that such a calcium phosphate-based photocatalyst, or indeed any fish/marine derived wastes, have been added to building materials. A key factor is th…
Single-dose Palonosetron for prevention of chemotherapy-induced nausea and vomiting in patients with aggressive non-Hodgkin's lymphoma receiving mode…
2011
PURPOSE: The control of nausea and vomiting induced by chemotherapy is paramount for overall treatment success in cancer patients. Antiemetic therapy during chemotherapy in lymphoma patients generally consists of anti-serotoninergic drugs and dexamethasone. The aim of this trial was to evaluate the efficacy of a single dose of palonosetron, a second-generation serotonin type 3 (5-HT(3)) receptor antagonist, in patients with aggressive non-Hodgkin's lymphoma receiving moderately emetogenic chemotherapy (MEC) containing steroids. METHODS: Patients received a single intravenous bolus of palonosetron (0.25 mg) before administration of chemotherapy. Complete response (CR) defined as no vomiting …
Hepatitis E virus-induced primary cutaneous CD30(+) T cell lymphoproliferative disorder.
2017
International audience; BACKGROUND & AIM:Several types of unexplained extra-hepatic manifestations, including haematological disorders, have been reported in the context of hepatitis E virus (HEV) infection. However, the underlying mechanism(s) of these manifestations are unknown. We provide evidence that HEV has an extra-hepatic endothelial tropism that can engage cutaneous T cells towards clonality.METHODS:A patient with a CD30(+) cutaneous T cell lymphoproliferative disorder (T-LPD) and biopsy-proven chronic HEV infection received three rounds of oral ribavirin treatment, administered either without or with interferon, and eventually achieved a sustained virologic response (SVR). Patholo…
Hokeja pirmsspēles apskata automātiska veidošana
2015
Hokeja pirmsspēles apskats, parasti ir ekspertu veidots rakstisks komandu salīdzinājums, kas balstās uz iepriekšējo spēļu statistiku un aktuālāko informāciju. Darbā aprakstīti būtiskākie aspekti automātiska pirmsspēles apraksta ģenerēšanā. Mērķis izveidot sistēmu, kas spēj izveidot saturīgus NHL pirmsspēles aprakstus. Darba rezultātā tika izveidota vienkārša sistēma, kas automātiski ievāc statistiku no NHL mājaslapas un spēj izveidot vienkāršus pirmsspēles apskatus.
Četras enceniklīna hidrogēnhlorīda monohidrāta formas: termodinamiskās stabilitātes, dehidratācijas un struktūru salīdzinājums
2016
Četras enceniklīna hidrogēnhlorīda monohidrāta formas: termodinamiskās stabilitātes, dehidratācijas un struktūru salīdzinājums. Rutkovska L., darba vadītājs Dr. ķīm. Bērziņš A., konsultants Mag. ķīm. Kons A. Maģistra darbs, 64 lappuses, 33 attēli, 9 tabulas, 82 literatūras avoti, 6 pielikumi. Latviešu valodā. Kopā iegūtas desmit enceniklīna hidrogēnhlorīda kristāliskās formas – patentētās monohidrāta I, II un X formas. Iegūtas arī līdz šim literatūrā neaprakstītas formas – monohidrāta III forma, nestehiometrisks hidrāts (II’ forma) un bezūdens V, VI, VII, VIII un XII formas. Apskatīta enceniklīna hidrogēnhlorīda monohidrāta I, II, III un X formu termodinamiskā stabilitāte un pārvērtības, iz…
Enceniklīna hidrogēnhlorīda solvātu meklējumi un to raksturošana
2017
Enceniklīna hidrogēnhlorīda solvātu meklējumi un to raksturošana. Iļjina N., darba vadītājs Mag. ķīm. Kons A. Bakalaura darbs, 42 lappuses, 22 attēli, 2 tabulas, 43 literatūras avoti, 3 pielikumi. Latviešu valodā. Darbā apkopota informācija par iepriekš zināmām enceniklīna hidrogēnhlorīda kristāliskajām formām, kā arī iegūti 22 jauni solvāti un 2 jaunas polimorfās formas. Apskatīta iegūto enceniklīna hidrogēnhlorīda solvātu stabilitāte un to desolvatācijas produkti, izmantojot rentgendifraktometrijas, termogravimetrijas/diferenciālā skenējošā kalorimetrijas metodes. Četriem solvātiem un divien polimorfiem tika aprēķinātas to kristāliskās struktūras no pulvera rentgendifrakcijas datiem un iz…
Associations of non-Hodgkin Lymphoma (NHL) risk with autoimmune conditions according to putative NHL loci.
2015
Autoimmune conditions and immune system-related genetic variations are associated with risk of non-Hodgkin lymphoma (NHL). In a pooled analysis of 8,692 NHL cases and 9,260 controls from 14 studies (1988-2007) within the International Lymphoma Epidemiology Consortium, we evaluated the interaction between immune system genetic variants and autoimmune conditions in NHL risk. We evaluated the immunity-related single nucleotide polymorphisms rs1800629 (tumor necrosis factor gene (TNF) G308A), rs1800890 (interleukin-10 gene (IL10) T3575A), rs6457327 (human leukocyte antigen gene (HLA) class I), rs10484561 (HLA class II), and rs2647012 (HLA class II)) and categorized autoimmune conditions as prim…