Search results for "NIH"

Aging and microRNA messaging : associations with systemic estrogen levels and physical performance

2018

This thesis took an innovative approach, which involved methodological development, to investigate microRNAs as candidate molecules and as genome-wide regulators of age, menopausal status and physical condition in both sexes. The focus was on potential serum microRNAs indicative of age, pre- or postmenopausal status, with or without estrogen- based hormone replacement therapy (HRT), and long-term physical training. MicroRNA associations with adiposity and inflammatory markers were also analyzed. Three different study designs were used: 1) the SAWEs study comprised healthy postmenopausal monozygotic twin sisters (n=11, 54-62 years) with discordance for HRT and premenopausal women (n=30, 20-4…

Heideggerin aukeama : tutkimuksia totuudesta ja taiteesta Martin Heideggerin avaamassa horisontissa

2001

This study is a philosophical work on Martin Heidegger's thinking. Its primary purpose is to study Heideggerian concepts. Secondly, it brings into focus two other thinkers who play with Heidegger 's thought, and thirdly, it applies Heideggerian thinking to truth and art. The study is compilation of eight articles, which are divided under three titles: I Heidegger and the Truth. II Heidegger and Truth in the Horizon of Nietzsche and Foucault, III Art in the Heideggerian Light. The main themes in this study are truth and art. The first part of the study is comprised of research work on Heid egger's theory and the concept of truth, which he present in his main work Sein und Zeit. Another impor…

Nietzsche en los ensayos del poeta Gottfried Benn

2002

Nietzsche no sólo fue objeto directo y tema central de varios poemas de Benn, como más adelante se podrá comprobar, sino que también constituye, junto con Goethe, Taine y Heinrich Mann, uno de los autores permanentes y predilectos de sus citas explícitas -más de cien- y es, sin lugar a dudas, el inspirador y la fuente principal de los temas recurrentes de su crítica meditación y de su penetrante mirada, siempre poéticas y poetológicas, sobre la cultura en la primera mitad del siglo pasado.

Development of antibiotic loaded biodegradable matrices to prevent superficial infections associated to total knee arthroplasty.

2019

Abstract Development of a pharmaceutical form for the superficial infections related with arthroplasties would be helpful for clinical practice. In this context, we set out to evaluate ciprofloxacin and gentamicin elution from systems based on chitosan. Films and semisolid hydrogels containing chitosan alone (2%) or in combination with gelatin (6%) or different proportions (from 12% to 36%) of tetrakis-(hydroxymethyl)-phosphonium-chloride (THPC) were tested as delivery systems. Different antibiotic doses were assayed (0.5 mg/cm2,1 mg/cm2 and 2 mg/cm2). Antibiotic release was studied for each formulation. In vitro cytocompatibility studies and a simulation exercise for bioactivity evaluation…

Free-volume Study in GeS2-Ga2S3-CsCl Chalcohalide Glasses Using Positron Annihilation Technique

2015

Abstract Positron annihilation lifetime spectroscopy combined with Doppler broadening of annihilation radiation was applied to study free-volume entities in Ge-Ga-S glasses having different amount of CsCl additives. It is shown that the structural changes caused by CsCl additives can be adequately described by positron trapping modes determined within two-state model. The results testify in a favor of rather unchanged nature of corresponding free-volume voids responsible for positron trapping in the studied glasses, when mainly concentration of these traps is a subject to most significant changes with composition.

Le tecniche costruttive di elementi di gesso nel complesso del Monte Calvario a Palma di Montechiaro

2008

Kestääkö ääni? : laulunopetuksen vaikutus opettajaksi valmistuvien äänen laatuun ja ilmaisuun

2017

The aim of this study was to investigate how regular singing lessons and deliberate practice impact future teachers’ voice quality and their expression in speech and singing. Previous research about teachers’ speaking voice has shown that kindergarten teachers and classroom teachers are at high risk of showing symptoms or developing disorders, which weaken their effectiveness of expression. The study is qualitative and experimental and it includes longitudinal vocal education, which lasted one academic year. This thesis was approached theoretically through existential phenomenology with a holistic conception of man. Data was gathered from eleven subjects and divided into three research grou…

Liikunta-aktiivisuuden ja kunnon yhteys insuliiniherkkyyteen 32-37-vuotiailla identtisillä kaksosmiehillä

2014

Mariita Anttila (2014). Liikunta-aktiivisuuden ja kunnon yhteys insuliiniherkkyyteen 32-37-vuotiailla identtisillä kaksosmiehillä. Terveystieteiden laitos, Jyväskylän yliopisto, liikunta-lääketieteen pro gradu-tutkielma, 60 s., 4 liitettä. Liialliset lihaskudoksen ja sisäelinten rasvakertymät, sekä lihasten käyttämättömyyden on todettu heikentävän elimistössä sokerinkulutusta ja insuliinin vaikutusta. Samalla tämä on lisännyt riskiä sairastua aineenvaihduntasairauksiin myös nuoremmilla. Tämän opinnäytetyön tarkoituksena oli tutkia liikunnan, kunnon ja kehonkoostumuksen yhteyttä insuliiniherkkyy-teen 32-37-vuotiailla kaksosmiehillä. Tutkimukseen valikoitui 23 identtistä (MZ) kaksosparia (N=4…

Many-particle theory for time-dependent quantum transport in nanostructures

2012

During the recent decades, molecular electronics has established its place as one of the promising fields in the nanoscience. The possibility to manufacture and control molecular junctions where single molecules are squeezed between the conducing electrodes has opened up new possibilities to develop nanoscale devices which could be employed as building blocks for future nanoelectronic applications. The driving force for this new branch of physics has been the experimental advances but also theoretical methods have been under intensive study and many theoretical tools have been developed to understand the electron transport processes in the nanoscale systems. This thesis focuses on developin…

Uncertainties on the determination of the strong coupling αs from the energy evolution of jet fragmentation functions at low z

2014

The QCD coupling alpha_s is determined at NLO*+NMLLA accuracy from the comparison of experimental jet data to theoretical predictions of the energy-evolution of the parton-to-hadron fragmentation function moments (multiplicity, peak, width, skewness) at low fractional hadron momentum z. From the existing e+e- and e-p jet data, we obtain alpha_s(m_Z^2) = 0.1195 +/- 0.0021 (exp.) {+0.0015}_{-0.0} (scale) at the Z mass. The uncertainties of the extracted alpha_s value are discussed.