Search results for "NIH"
showing 10 items of 1190 documents
Amphoteric, prevailingly cationic L-arginine polymers of poly(amidoamino acid) structure: Synthesis, acid/base properties and preliminary cytocompati…
2013
A linear amphoteric poly(amidoamino acid), L-ARGO7, is prepared by Michael-type polyaddition of L-arginine with N,N′-methylenebisacrylamide. Chain-extension of acrylamide end-capped L-ARGO7 oligomers with piperazine leads to high-molecular-weight copolymers in which L-arginine maintains its absolute configuration. Acid/base properties of L-ARGO7 polymers show isolectric points of ≈10 and positive net average charges per repeating unit at pH = 7.4 from 0.25 to 0.40. These arginine-rich synthetic polymers possibly share some of the unique biological properties of polyarginine cell-permeating peptides. In vitro tests with mouse embryo fibroblasts balb/3T3 clone A31 show that L-ARGO7 polymers a…
Jälkimodernin ajattelun alkuperästä : Nietzschen moninaisen mielen poliittinen ja filosofinen luenta
2008
Tutkimukseni käsittelee Friedrich Nietzschen poliittista ja filosofista ajattelua. Olen rakentanut Nietzschen poliittisesta filosofiasta kokonaistulkinnan. Tulkinnassa olen pyrkinyt osoittamaan keskeisien postmodernien Nietzsche-tulkintojen olevan mitä suuremmassa määrin vastakkaisia tekemälleni Nietzsche-luennalle, jota pidän uskollisempana Nietzschen kokonaisajattelua tarkastellen. Tutkimalla Nietzschen kokonaisfilosofisia pohdintoja olen pyrkinyt paikantamaan postmodernin ajattelun puutteita ja ongelmia. Tärkeimmäksi ongelmaksi olen paikantanut auktoriteetin puutteen niin yksilön kuin yhteisön tahdon muodostukselle. Tutkielmassa olen päätynyt näkemykseen, että postmoderni auktoriteetteja…
Onihomikozes ārstēšanas pamatprincipi
2015
Diplomdarba tēma izvēlēta vadoties no problēmu aktualitāti. Nagu sēnīšu infekcija bieži vien tiek uzskatīta tikai par kosmētiska rakstura problēmu, tāpēc tās ārstēšanai netiek veltīta īpaša uzmanība. Neārstējot nagu infekciju, tā progresē mēnešiem un gadiem ilgi, bojājot ne tikai nagu izskatu, bet radot diskomfortu un sāpes, kas var negatīvi ietekmēt gan cilvēka pašsajūtu, gan profesionālo un sociālo dzīvi. Onihomikožu vietējo terapiju nozīmē kombinēti ar sistēmisko ārstēšanu. Lokālās terapijas efektivitāte ir atkarīga no ārsta un pacienta sadarbības. Nepabeigta, patvaļīgi pārtraukta onihomikozes ārstēšana veicina sēnīšu rezistences attīstību, gan pašam pacientam, gan populācijā kopumā. Dip…
Assessment of sleep disturbances with the athlete sleep screening questionnaire in Chinese athletes.
2021
This study investigated the factors that are associated with sleep disturbances among Chinese athletes. Sleep quality and associated factors were assessed by the Athlete Sleep Screening Questionnaire (ASSQ, n = 394, aged 18–32 years, 47.6% female). Sleep difficulty score (SDS) and level of sleep problem (none, mild, moderate, or severe) were used to classify participants' sleep quality. Categorical variables were analyzed by Chi-square or fisher's exact tests. An ordinal logistic regression analysis was used to explore factors with poor sleep (SDS ≥8). Approximately 14.2% of participants had moderate to severe sleep problem (SDS ≥8). Fifty-nine percent of the athletes reported sleep distu…
Nitrate and nitrite in the diet: How to assess their benefit and risk for human health
2015
Nitrate is a natural constituent of the human diet and an approved food additive. It can be partially converted to nitrogen monoxide, which induces vasodilation and thereby decreases blood pressure. This effect is associated with a reduced risk regarding cardiovascular disease, myocardial infarction, and stroke. Moreover, dietary nitrate has been associated with beneficial effects in patients with gastric ulcer, renal failure, or metabolic syndrome. Recent studies indicate that such beneficial health effects due to dietary nitrate may be achievable at intake levels resulting from the daily consumption of nitrate-rich vegetables. N-nitroso compounds are endogenously formed in humans. However…
SingleChannelNet : A model for automatic sleep stage classification with raw single-channel EEG
2022
In diagnosing sleep disorders, sleep stage classification is a very essential yet time-consuming process. Various existing state-of-the-art approaches rely on hand-crafted features and multi-modality polysomnography (PSG) data, where prior knowledge is compulsory and high computation cost can be expected. Besides, it is a big challenge to handle the task with raw single-channel electroencephalogram (EEG). To overcome these shortcomings, this paper proposes an end-to-end framework with a deep neural network, namely SingleChannelNet, for automatic sleep stage classification based on raw single-channel EEG. The proposed model utilizes a 90s epoch as the textual input and employs two multi-conv…
Cognitive behavioural therapy interventions for insomnia among shift workers: RCT in an occupational health setting
2019
Abstract Introduction The aim of the study was to compare the effectiveness of cognitive behavioural therapy interventions for insomnia (CBT-I) to that of a sleep hygiene intervention in a randomized controlled design among shift workers. We also studied whether the features of shift work disorder (SWD) affected the results. Methods A total of 83 shift workers with insomnia disorder were partially randomized into a group-based CBT-I, self-help CBT-I, or sleep hygiene control intervention. The outcomes were assessed before and after the interventions and at 6-month follow-up using questionnaires, a sleep diary, and actigraphy. Results Perceived severity of insomnia, sleep-related dysfunction…
Minihandbola integrēšana sporta stundās
2017
Diplomdarbs ir par minihandbola integrēšanu sporta stundās. Diplomdarba mērķis ir noskaidrot, kā veiksmīgāk integrēt minihandbola apguvi sporta stundās. Darbs sastāv no ievada, teorētiskās, praktiskās daļas, nobeiguma un pielikuma. Teorētiskajā daļā tiek analizēta literatūra par handbolu un minihandbolu. Kā arī par skolēnu vecumposmiem, sīkāk pievēršot uzmanību pusaudžiem. Praktiskajā daļa ir apkopoti Latvijas handbola treneru aptauju rezultāti, sīkāk apskaidrots, kas ir integrēšana un kā tā tika veikta diplomdarba ietvaros Rīgas vidusskolā, kas ir atspoguļota ar darba autora izveidotajiem testiem.
Global analysis of the pMSSM in light of the Fermi GeV excess: prospects for the LHC Run-II and astroparticle experiments
2016
We present a new global fit of the 19-dimensional phenomenological Minimal Supersymmetric Standard Model (pMSSM-19) that comply with all the latest experimental results from dark matter indirect, direct and accelerator dark matter searches. We show that the model provides a satisfactory explanation of the excess of gamma-rays from the Galactic centre observed by the Fermi~Large Area Telescope, assuming that it is produced by the annihilation of neutralinos in the Milky Way halo. We identify two regions that pass all the constraints: the first corresponds to neutralinos with a mass ~80-100 GeV annihilating into WW with a branching ratio of 95% ; the second to heavier neutralinos, with mass ~…
Poissonin yhtälön nopeat ratkaisijat
2016
Tutkielmassa esitellään Poissonin yhtälö sekä sen diskretointi. Lisäksi käydään läpi kaksi nopeaa numeerista menetelmää yhtälön ratkaisemiseksi. Yksinkertaisuuden vuoksi rajoitutaan kaksiulotteisiin tehtäviin, joissa on voimassa Dirichle’t reunaehto. Ensimmäinen menetelmistä on monihilamenetelmä, joka on iteratiivinen menetelmä, ja toisena syklinen reduktio, joka on suora menetelmä. Molemmat menetelmät ovat hyvin tehokkaita sekä helposti rinnakkaistuvia. In this thesis we introduce Poisson’s equation and its discretization. In addition we go through two fast numerical methods for solving the equation. The thesis is limited only to two-dimensional cases with Dirichlet boundary condition. The…