Search results for "NIH"
showing 10 items of 1190 documents
Targeting Bacterial Sortase A with Covalent Inhibitors: 27 New Starting Points for Structure-Based Hit-to-Lead Optimization.
2019
Because of its essential role as a bacterial virulence factor, enzyme sortase A (SrtA) has become an attractive target for the development of new antivirulence drugs against Gram-positive infections. Here we describe 27 compounds identified as covalent inhibitors of
Recombinant mussel protein Pvfp-5β: A potential tissue bioadhesive
2019
During their lifecycle, many marine organisms rely on natural adhesives to attach to wet surfaces for movement and self-defence in aqueous tidal environments. Adhesive proteins from mussels are biocompatible and elicit only minimal immune responses in humans. Therefore these proteins have received increased attention for their potential applications in medicine, biomaterials and biotechnology. The Asian green mussel Perna viridis secretes several byssal plaque proteins, molecules that help anchor the mussel to surfaces. Among these proteins, protein-5β (Pvfp-5β) initiates interactions with the substrate, displacing interfacial water molecules before binding to the surface. Here, we establis…
Menopause and adipose tissue: miR-19a-3p is sensitive to hormonal replacement
2018
Tissue-specific effects of 17 beta-estradiol are delivered via both estrogen receptors and microRNAs (miRs). Menopause is known to affect the whole-body fat distribution in women. This investigation aimed at identifying menopause-and hormone replacement therapy (HRT)-associated miR profiles and miR targets in subcutaneous abdominal adipose tissue and serum from the same women. A discovery phase using array technology was performed in 13 women, including monozygotic twin pairs discordant for HRT and premenopausal young controls. Seven miRs, expressed in both adipose tissue and serum, were selected for validation phase in 34 women from a different cohort. An age/menopause-related increase of …
ACT for sleep - Internet-delivered self-help ACT for sub-clinical and clinical insomnia : A randomized controlled trial
2019
Background: Sleep disturbances are a common health problem. New and more accessible alternatives are needed to improve the availability of psychological treatments for insomnia. - Objective: The aim of the present study was to investigate the effects of a self-help Acceptance and Commitment Therapy-based web-intervention for sleep disturbances. - Method: Participants (N = 86) reporting symptoms of insomnia were randomly assigned to an Internet-delivered ACT (iACT, n = 43) or a control condition (WLC, n = 40) and assessed with standardized self-report measures related to sleep (ISI, BNSQ, ESS, DBAS), psychological symptoms (BDI-II, SCL-90), life satisfaction, and ACT-related processes (AAQ-2…
Measurement of the W boson mass
1996
The W boson mass is measured using proton-proton collision data at root s = 13 TeV corresponding to an integrated luminosity of 1.7fb(-1) recorded during 2016 by the LHCb experiment. With a simultaneous fit of the muon q/p(T) distribution of a sample of W ->mu y decays and the phi* distribution of a sample of Z -> mu mu decays the W boson mass is determined to be
Search for a Dark Leptophilic Scalar in e(+) e(-) Collisions
2020
Many scenarios of physics beyond the standard model predict the existence of new gauge singlets, which might be substantially lighter than the weak scale. The experimental constraints on additional scalars with masses in the MeV to GeV range could be significantly weakened if they interact predominantly with leptons rather than quarks. At an e+e- collider, such a leptophilic scalar (φL) would be produced predominantly through radiation from a τ lepton. We report herein a search for e+e-→τ+τ-φL, φL→ℓ+ℓ- (ℓ=e, μ) using data collected by the BABAR experiment at SLAC. No significant signal is observed, and we set limits on the φL coupling to leptons in the range 0.04<mφL<7.0 GeV. These bounds s…
Search for a Stable Six-Quark State at BABAR
2019
Recent investigations have suggested that the six-quark combination uuddss could be a deeply bound state (S) that has eluded detection so far, and a potential dark matter candidate. We report the first search for a stable, doubly strange six-quark state in Upsilon -> S anti-Lambda anti-Lambda decays based on a sample of 90 million Upsilon(2S) and 110 million Upsilon(3S) decays collected by the BABAR experiment. No signal is observed, and 90% confidence level limits on the combined Upsilon(2S,3S) -> S anti-Lambda anti-Lambda branching fraction in the range (1.2-1.4)x10^-7 are derived for m_S < 2.05 GeV. These bounds set stringent limits on the existence of such exotic particles.
Measurement of the branching ratio and an upper limit on
1995
Abstract Using 1.45 million hadronic Z decays collected by the ALEPH experiment at LEP, the b → τ − ν - τ X branching ratio is measured to be 2.75 ± 0.30 ± 0.37%. In addition an upper limit of 1.8 × 10 −3 at 90% confidence level is placed upon the exclusive branching ratio of B − → τ − ν - τ . These measurements are consistent with SM expectations, and put the constraint tan β M h ± GeV −1 at 90% confidence level on all Type II two Higgs doublet models (such as the MSSM).
Updated measurement of the τ lepton lifetime
1997
A new measurement of the mean lifetime of the tau lepton is presented. Three different analysis methods are applied to a sample of 90000 tau pairs, collected in 1993 and 1994 with the ALEPH detector at LEP. The average of this measurement and those previously published by ALEPH is tau_tau = 290.1 +- 1.5 +- 1.1 fs.
Lymphoma cell apoptosis in the liver induced by distant murine cytomegalovirus infection.
2006
ABSTRACTCytomegalovirus (CMV) poses a threat to the therapy of hematopoietic malignancies by hematopoietic stem cell transplantation, but efficient reconstitution of antiviral immunity prevents CMV organ disease. Tumor relapse originating from a minimal residual leukemia poses another threat. Although a combination of risk factors was supposed to enhance the incidence and severity of transplantation-associated disease, a murine model of a liver-adapted B-cell lymphoma has previously shown a survival benefit and tumor growth inhibition by nonlethal subcutaneous infection with murine CMV. Here we have investigated the underlying antitumoral mechanism. Virus replication proved to be required, …