Search results for "NIST"
showing 10 items of 13738 documents
Neuroimagen y adicción I: Correlatos neuroanatómicos y funcionales de la administración aguda, el craving y el consumo crónico de psicoestimulantes
2007
En los últimos años ha aumentado el interés por el estudio de los correlatos neurobiológicos del consumo de drogas psicoestimulantes, como la cocaína o el éxtasis. La aplicación de las técnicas de neuroimagen ha permitido examinar in vivo los efectos agudos de la administración de estas sustancias, los correlatos cerebrales del deseo intenso por consumirlas (craving), o las alteraciones funcionales o morfológicas asociadas al consumo crónico. Los objetivos de esta revisión son: (1) explicar brevemente las técnicas de neuroimagen utilizadas en la investigación de drogodependencias (2) presentar los hallazgos más actualizados de neuroimagen en el estudio de los correlatos cerebrales del consu…
Neuroimagen y adicción II: Correlatos neuroanatómicos y funcionales de la administración aguda, el craving y el consumo crónico de opiáceos, alcohol …
2008
En las últimas décadas las técnicas de neuroimagen han contribuido en gran medida al estudio in vivo de los efectos neurobiológicos del consumo agudo y crónico de sustancias de abuso. El incremento en los últimos años del consumo de alcohol y cannabis, así como las graves consecuencias asociadas al consumo de opiáceos han contribuido al aumento del interés por estudiar los efectos de estas sustancias en el sistema nervioso central. Los objetivos de esta revisión son: (1) presentar los hallazgos más actualizados de neuroimagen en el estudio de los correlatos cerebrales del consumo de opiáceos, alcohol y cannabis, teniendo en cuenta: (i) la administración aguda de estas sustancias, (ii) el cr…
Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the a…
2015
Chronic alcohol exposure reduces endocannabinoid activity and disrupts adult neurogenesis in rodents, which results in structural and functional alterations. Cannabinoid receptor agonists promote adult neural progenitor cell (NPC) proliferation. We evaluated the protective effects of the selective CB1 receptor agonist ACEA, the selective CB2 receptor agonist JWH133 and the fatty-acid amide-hydrolase (FAAH) inhibitor URB597, which enhances endocannabinoid receptor activity, on NPC proliferation in rats with forced consumption of ethanol (10%) or sucrose liquid diets for 2 weeks. We performed immunohistochemical and stereological analyses of cells expressing the mitotic phosphorylation of his…
Universities' mundaneness and regional engagement : Setting the stage
2022
This chapter introduces the main logic of this volume, which starts from the grassroots level of universities’ “everyday” engagements, looking at the manifold ways in which university knowledge agents build connections with multiple regional partners across the public and private sectors, and civic society more generally. Roles, functions and normative orientations of universities in the context of their surrounding regions have, in many cases, been taken for granted and, thus, have not been systematically addressed and/or still lack theorizing, due to the focus being on extraordinary, large-scale and eye-catching activities, and financially impressive transactions such as patents and spin-…
Universities and regions: New insights and emerging developments
2022
In this concluding chapter, the editors take stock of the empirical findings across the cases and levels of analysis and link the empirical evidence to the analytical framework presented in Chapter 2. In so doing, we revisit the interplay between macro, meso, and micro dimensions of the environments as well as the temporality in which higher education institutions (HEIs) operate, which, taken together, help shape the mundane (everyday) or routine behaviours of actors within HEIs. The editors conclude by suggesting that the empirical evidence and conceptual insights advanced in this volume represent a needed first step, yet more needs to be done (future studies) to further unpack how the dyn…
Unpacking Mundaneness : A novel conceptual framework for universities and regional engagement
2022
In this chapter, we debate the current view on university-regional engagements and suggest a renewed theoretical framework based on four main elements – macro, meso, micro dimensions, as well as a meta-dimension of temporality that cuts across all levels. The macro environment is typically defined as pertaining to public policies, culture, laws, and economy, while the meso environment includes links between the macro (societal) forces and the micro (agents) level through intermediate institutions and structures and is characterized by the processes and mechanisms of interaction of different actors. The micro level is about agency – organizations or individuals/groups within organizations – …
Лифляндская губернская подготовительная комиссія, 1906 г. [Лифляндская губернская подготовительная комиссия, 1906 г.]
1906
Содержание: Журналы заседаний Лифляндской губернской подготовительной комиссии (№ 1-13) по делам земского самоуправления, по учебной части, по делам церковного управления, по аграрным вопросам, о реорганизации волостного самоуправления, по судебной части. Список членов Лифл. губернской подготовительной комиссии. Перечен вопросов, внесенных на обсуждение Лифл. подготовительной комисси и другие материалы.
El reconocimiento como fundamento de una ética de la función pública. Un marco para su aplicación en organizaciones públicas.
2013
La tesis propone que el paradigma filosófico del reconocimiento recíproco es el más adecuado para fundamentar una ética aplicada a la función pública. Tras aplicar el método de ética aplicada como hermenéutica crítica, identifica los principales contenidos normativos de una ética de la función pública en los discursos y prácticas en los que actualmente se manifiesta esta ética. Luego, reconstruye parte del itinerario filosófico del concepto de reconocimiento recíproco para comprender las relaciones entre administradores y admionistrados como relaciones de reconocimiento. Finalmente, la tesis explora cómo desde este enfoque es posible profundizar la comprensión y proponer mejoras para la apl…
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
2021
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…
Cardiovascular and Renal Outcomes of Renin–Angiotensin System Blockade in Adult Patients with Diabetes Mellitus: A Systematic Review with Network Met…
2016
Background Medications aimed at inhibiting the renin–angiotensin system (RAS) have been used extensively for preventing cardiovascular and renal complications in patients with diabetes, but data that compare their clinical effectiveness are limited. We aimed to compare the effects of classes of RAS blockers on cardiovascular and renal outcomes in adults with diabetes. Methods and Findings Eligible trials were identified by electronic searches in PubMed/MEDLINE and the Cochrane Database of Systematic Reviews (1 January 2004 to 17 July 2014). Interventions of interest were angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and direct renin (DR) inhibitors. T…