Search results for "NMP"

showing 10 items of 12 documents

Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

2021

Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…

ABCC1 ATP binding cassette subfamily C member 1IC50 half maximal inhibitory concentrationMultidrug resistancePharmacologyNADPH reduced nicotinamide adenine dinucleotide phosphateF bioavailabilitychemistry.chemical_compoundPCR polymerase chain reaction0302 clinical medicineMDR multidrug resistanceECL electrochemiluminescencet1/2 elimination half-lifeLC–MS liquid chromatography coupled with mass spectrometryN.D. not detectedGeneral Pharmacology Toxicology and PharmaceuticsBBB blood–brain barriermedia_commonATF3 activating transcription factor 30303 health sciencesChemistryABC ATP-binding cassetteNMPA National Medical Products AdministrationPXR pregnane X receptorSDS-PAGE sodium dodecyl sulfate-polyacrylamide gel electrophoresisHBSS Hankʹs balanced salt solutionABCB1Combination chemotherapyProdrugMarsdenia tenacissimaCmax peak concentrationPaclitaxelGAPDH glyceraldehyde-3-phosphate dehydrogenase030220 oncology & carcinogenesisBHI brain heart infusionOriginal ArticleAUC0–∞ area under plasma concentration vs. time curveMRT mean residence timeDrugmedia_common.quotation_subjectRM1-950Vd volume of distributionABCB1 ATP binding cassette subfamily B member 1UIC-2 mouse monoclonal ABCB1 antibodyABCG2 ATP binding cassette subfamily G member 2Combination chemotherapyCYP cytochrome P450 isozymePI propidium iodideTEER transepithelial electrical resistance03 medical and health sciencesPBS phosphate buffer salineFBS fetal bovine serumDox doxorubicinIn vivoPOP polyoxypregnanemedicine030304 developmental biologyEVOM epithelial tissue voltohmmeterTmax time for peak concentrationCancerLBE lowest binding energyPE phycoerythrinmedicine.diseaseMultiple drug resistancePolyoxypregnanePapp apparent permeabilityN.A. not applicableCancer cellH&E hematoxylin and eosinMDR1a multidrug resistance protein 1aTherapeutics. PharmacologyqPCR quantitative PCRM. tenacissima Marsdenia tenacissimaCL clearanceSD standard derivationActa Pharmaceutica Sinica B
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Use of computed tomography for chest to determine SARS-CoV-2 (COVID-19) infectious lung damage during medical emergency stage

2021

Bakalaura darba tēma ir “Krūšu kurvja datortomogrāfijas izmeklējums SARS-CoV-2 (COVID-19) infekcijas plaušu bojājumu noteikšanai neatliekamās medicīniskās palīdzības etapā”. Bakalaura darba tēma ir aktuāla, jo neraugoties uz negatīvo statistiku, šobrīd ar pieejamajām vizuālās diagnostikas metodēm iespējams agrīni dagnosticēt COVID-19 infekcijas izraisītos plaušu bojājumus. Darba mērķis ir noskaidrot krūšu kurvja datortomogrāfijas izmeklējuma pielietojumu SARS-CoV-2 (COVID-19) infekcijas plaušu bojājumu noteikšanai neatliekamās medicīniskās palīdzības etapā. Mērķa sasniegšanai tika izvirzīti sekojoši uzdevumi: analizēt literatūru par krūšu kurvja datortomogrāfijas anatomiju, analizēt literat…

DatortomogrāfijaNMPUKretrospektīvs kvalitatīvs pētījumsCOVID-19Medicīna
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Rol del complejo RUNX1-CBF-β/HIPK2/p300/p53 en la evolución leucémica de las neoplasias mieloproliferativas crónicas

2019

Las neoplasias mieloproliferativas crónicas (NMPs) son procesos cancerígenos en los que se produce una expansión clonal de una o varias poblaciones de progenitores hematopoyéticos de estirpe mieloide. En las fases iniciales de la enfermedad, éstos presentan una adecuada diferenciación celular, lo que conlleva una descompensación final de los diferentes tipos celulares en médula ósea y sangre periférica y la consiguiente aparición de una serie de síntomas asociados que pueden llegar a producir importantes citopenias o complicaciones vasculares. A pesar de que las NMPs pueden mantenerse relativamente controladas en su fase crónica mediante un tratamiento adecuado, éstas patologías tienen una …

EP300RUNX1leucemogénesisMFapoptosisPVHIPK2leucemia mieloide:CIENCIAS DE LA VIDA [UNESCO]proliferaciónNeoplasias mieloproliferativasUNESCO::CIENCIAS DE LA VIDAhematopoyesisciclo celularTP53NMPsLMCCBF-βTE
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Contemporary growth studies and Eastern Europe : from scholar debates towards a comparative analysis on Bulgaria, Hungary, Poland and Romania, 1970-1…

2000

Hungarygrowth studiesMPSRomaniagrowth ratesEastern EuropeNMPUnkariGDPItä-EurooppaSNAForeign tradePolandPuolaBulgariakansainvälinen kauppa
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Videonovērošanas sistēmu problēmas un to risinājumi

2017

Bakalaura darba “Videonovērošanas sistēmu problēmas un to risinājumi” mērķis ir izvērtēt uzņēmumu “A”,”B” un “C” esošās situācijas, izstrādāt un ieviest risinājumus, lai novērstu uzņēmumos novērotās problēmas. Darbā tiks apskatītas uzņēmuma “A” problēmas: neprecīza notikumu saņemšana gadījumos, kad kameras nestrādā un nespēju noteikt vai tiek veikts video ieraksts; uzņēmuma “B” problēma: neērts un laikietilpīgs datu izgūšanas veids; uzņēmuma “C” problēma: uzņēmumam slēdzot līgumu ar apakšuzņēmēju, netiek noteiktas skaidras vadlīnijas darbu veikšanai. Vadoties pēc izvirzītajiem uzdevumiem, uzņēmumam “A” tika izveidots veids, kā saņemt precīzus notikumus un izveidota kritisko elementu pārraud…

IP kameraMilestone XprotectDatorzinātneSSHNetXMSSNMP
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In vitro evaluation of poloxamer in situ forming gels for bedaquiline fumarate salt and pharmacokinetics following intramuscular injection in rats

2019

Graphical abstract

In situPO Propylene oxideIV IntravenousP338 Poloxamer 338lcsh:RS1-441Pharmaceutical Sciencechemistry.chemical_compoundn Sample sizeSD Standard deviationIM Intramuscularchemistry.chemical_classificationC0 Analyte plasma concentration at time zeroDoE Design of experimentsUV UltravioletPharmacology. TherapyK2.EDTA Potassium ethylenediaminetetraacetic acidLC–MS/MS Liquid chromatography-tandem mass spectrometryH&E Hematoxylin and eosintmax Sampling time to reach the maximum observed analyte plasma concentrationIn situ forming gelsCMC Critical micellar concentrationCmax Maximum observed analyte plasma concentrationIntramuscular injectionDN Dose normalizedGPT Gel point temperaturePLGA Poly-(DL-lactic-co-glycolic acid)TFA Trifluoroacetic acidCAN AcetonitrileATP Adenosine 5′ triphosphateSalt (chemistry)Polyethylene glycolPoloxamerArticlelcsh:Pharmacy and materia medicaPharmacokineticsIn vivoUHPLC Ultra-high performance liquid chromatographyPharmacokineticsAUClast Area under the analyte concentration versus time curve from time zero to the time of the last measurable (non-below quantification level) concentrationEO Ethylene oxideNMP N-methyl-2-pyrrolidoneComputingMethodologies_COMPUTERGRAPHICSAUC∞ Area under the analyte concentration vs time curve from time zero to infinite timeP407 Poloxamer 407In vitro releasePoloxamerCMT Critical micellar temperatureGel erosionIn vitrot1/2 Apparent terminal elimination half-lifechemistryMDR-TB Multi-drug resistant tuberculosisAUC80h Area under the analyte concentration versus time curve from time zero to 80 htlast Sampling time until the last measurable (non-below quantification level) analyte plasma concentrationMRM Multiple reaction monitoringNuclear chemistrySustained releaseInternational Journal of Pharmaceutics: X
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VALUTAZIONE CLINICA DELLA PROTEINA 22 DELLA MATRICE NUCLEARE COME MARCATORE TUMORALE NEL FOLLOW-UP DEI TUMORI A CELLULE TRANSIZIONALI DELLA VESCICA

2008

OBJECTIVES. Biomarkers (BTA, NMP22, FDP etc.) have been and continue to be evaluated as adjuncts or substitutes for cystoscopy, which is invasive and uncomfortable for some patients. Nuclear matrix protein-22 (NMP22) is involved in the regulation of nuclear processes. The main objective of the present study is to evaluate the clinical utility of urinary NMP22 as a tumor marker in the follow-up of transitional cell carcinoma (TCC) of the bladder. MATERIALS AND METHODS. The study included 62 patients undergoing follow-up, who had had TCC of bladder but who were disease-free at the beginning of the study, as confirmed by cystoscopy. Urine samples were collected for urinary cytology and NMP22 t…

NMP22 BIOMARKERS TRANSITIONAL CELL CARCINOMA OF THE BLADDERSettore MED/24 - Urologia
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Predictive value of positive NMP22 in patients with negative cytology and cystoscopy.

2010

NMP22 bladder cancer cytologySettore MED/24 - Urologia
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Smart Monitoring for Semantic Wireless (SCADA/DCS) Systems with Semantic SNMP Protocol.

2015

International audience; n this paper we propose a new implementation of SNMP protocol through (WS) and SOAP protocol, for wireless semantic (SCADA/DCS) systems and (IT-SCADA) platform monitoring. (WS) and SOAP may run on top of secure transport services implemented through protocols like HTTPS combined with industrial protocols as (DNP3, SOAP, ISM BAND, and ZIGBEE).We chose ZIGBBE wireless protocol for implementing our semantic security (IT-SCADA) management platform with semantic SNMP protocol via WS. To detect and infiltrate wireless radio network and semantic attacks, the use of (WS) gateways is needed to include SNMP devices into (WS) based management architecture. The evaluation shows …

Web Services (WS)ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKSSemantic Wireless (SCADA/D CS)(IT-SCADA) platform[INFO.INFO-ES]Computer Science [cs]/Embedded SystemsSemantic SNMP Prot ocol[ INFO.INFO-ES ] Computer Science [cs]/Embedded Systems[INFO.INFO-ES] Computer Science [cs]/Embedded Systems
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Urinary cytology and nuclear matrix protein 22 in the detection of bladder cancer recurrence other than transitional cell carcinoma

2008

OBJECTIVE: To assess the value of nuclear matrix protein-22 (NMP22), compared with urinary cytology, in predicting the recurrence of bladder cancer that is not transitional cell carcinoma (non-TCC). PATIENTS AND METHODS: We tested the sensitivity, specificity and the predictive accuracy of NMP22 in the context of non-TCC bladder cancer recurrence, and compared it to the performance of urinary cytology. The study group comprised 2687 patients with history of non-muscle-invasive bladder cancer from 10 centres across four continents. RESULTS: The mean patient age was 64.8 years and 75.4% were men; of all patients, 513 (19.1%) had positive urinary cytology, 906 (33.7%) had a positive NMP22 test…

bladder cancer urinary cytology NMP22 urinary markers
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