Search results for "NOD"
showing 10 items of 4007 documents
Folate-targeted supramolecular vesicular aggregates as a new frontier for effective anticancer treatment in in vivo model.
2012
Abstract Supramolecular vesicular aggregates (SVAs), made up by self-assembling liposomes and polyasparthydrazide co-polymers conjugated to folic acid molecules were extensively investigated in this manuscript as potential active targeting formulation for anticancer drug delivery. Folate-targeted systems (FT-SVAs) were used to treat breast cancer and to further proof the potential in vivo administration of these systems for the therapeutic treatment for several aggressive solid tumors. The physicochemical and technological parameters of FT-SVAs are suitable for their potential in vivo administration. The chemotherapeutic activity of GEM-loaded FT-SVAs was increased during in vivo experiment…
Antioxidant Properties of a Supercritical Fluid Extract of the Halophyte Mesembryanthemum nodiflorum L. from Sicilian Coasts: Nutraceutical and Cosme…
2020
The aim of this paper was to obtain different extracts from the aerial parts of Mesembryanthemum nodiflorum, comparing traditional extraction (using solvents with increasing polarity such as hexane, ethanol 80%, acetone 70% and water) with an eco-friendly technique (supercritical fluid extraction (SFE))
Nepilna laika nodarbinātība Latvijā: studentu perspektīva
2017
Bakalaura darba tēma ir “Nepilna laika nodarbinātība Latvijā: studentu perspektīva”. Eiropas Savienības dalībvalstīs liela nozīme tiek piešėirta jauniešu bezdarba samazināšanai. Lai arī nepilna laika nodarbinātība Latvijā ir maz izplatīta, tā ir pieprasīta studējošu jauniešu vidū. Pētījuma mērėis ir noskaidrot studējošu jauniešu pieĦemtās prakses un to vērtējumu, apvienojot pilna laika studijas ar nepilna laika nodarbinātību Latvijā. Pētījuma rezultāti tiek skatīti darba, izglītības un citu dzīves jomu saskaĦošanas kontekstā. Bakalaura darbs satur 44 lappuses, 1 pielikumu, tā sagatavošanā izmantoti 28 literatūras un informācijas avoti.
2016
Background Transcatheter aortic valve implantation (TAVI) has become the treatment of choice in patients with severe aortic valve stenosis who are not eligible for operative replacement and an alternative for those with high surgical risk. Due to high age and smoking history in a high proportion of TAVI patients, suspicious findings are frequently observed in pre-procedural chest computer tomography (CCT).
Apendektomijas epidemioloģija pēc Bērnu klīniskās universitātes slimnīcas datiem 2005. - 2015. gadā
2017
Pētījumā tika apskatīta tēma "Apendektomijas epidemioloģija pēc Bērnu klīniskās universitātes slimnīcas datiem 2005. - 2015. gadā”, analizēta bērnu akūta apendicīta saslimstība un to histoloģisku apakštipu izplatība. Pielietota retrospektīva analītiskā pētniecības metode. Teorētiskā daļa balstās uz 44 literatūras avotiem. Pētījumā izmantoti dati no 2279 nosūtījumiem uz patoloģisku izmeklēšanu no slimnīcas arhīva; papildus tiek analizētas materiāla histoloģiskās un imūnhistoķīmiskās pārmaiņas. Izveidota datubāze, veikta datu statistiskā apstrāde. Analīze pierādīja, ka bērnu saslimstība ar apendicītu ir samēra stabila un atkarīga no vecuma un dzimuma (prevalē zēni skolnieki); pārsvarā tiek iz…
Morphological, karyological and taxonomic remarks on Ferulago nodosa (L.) Boiss. (Apiaceae)
2012
Abstract Western (Sicilian) and eastern (Balcan-aegean) populations of the Balcan-tyrrhenian Ferulago nodosa are reported to be different in some morphological characters, and were considered different species by some authors in XIX century. In this work, fruit and pollen morphologies have been compared in Sicilian and Cretan plants; also, the chromosome number of Sicilian plants has been ascertained. Preliminary results highlight a general homogeneity between the two populations, nevertheless showing significant differences in some parameters (fruit form, pollen size). For this reason, and considering the geographic disjunction of the Sicilian plants, the two populations are proposed to be…
Exceptionally preserved soft parts in fossils from the Lower Ordovician of Morocco clarify stylophoran affinities within basal deuterostomes.
2019
10 pages; International audience; The extinct echinoderm clade Stylophora consists of some of the strangest known deuterostomes. Stylophorans are known from complete, fully articulated skeletal remains from the middle Cambrian to the Pennsylvanian, but remain difficult to interpret. Their bizarre morphology, with a single appendage extending from a main body, has spawned vigorous debate over the phylogenetic significance of stylophorans, which were long considered modified but bona fide echinoderms with a feeding appendage. More recent interpretation of this appendage as a posterior “tail-like” structure has literally turned the animal back to front, leading to consideration of stylophorans…
Nonlinear nonhomogeneous Neumann eigenvalue problems
2015
We consider a nonlinear parametric Neumann problem driven by a nonhomogeneous differential operator with a reaction which is $(p-1)$-superlinear near $\pm\infty$ and exhibits concave terms near zero. We show that for all small values of the parameter, the problem has at least five solutions, four of constant sign and the fifth nodal. We also show the existence of extremal constant sign solutions.
Reduced complexity models in the identification of dynamical networks: Links with sparsification problems
2009
In many applicative scenarios it is important to derive information about the topology and the internal connections of more dynamical systems interacting together. Examples can be found in fields as diverse as Economics, Neuroscience and Biochemistry. The paper deals with the problem of deriving a descriptive model of a network, collecting the node outputs as time series with no use of a priori insight on the topology. We cast the problem as the optimization of a cost function operating a trade-off between accuracy and complexity in the final model. We address the problem of reducing the complexity by fixing a certain degree of sparsity, and trying to find the solution that “better” satisfi…
Principles of care of patients with temporary tracheostomy in the intensive care unit
2021
Bakalaura darba tēma “Pacientu ar pagaidu traheostomu aprūpes principi intensīvās terapijas nodaļā”. Tēmas aktualitāti pamato tas, ka pašlaik nav izstrādātas skaidras klīniskās vadlīnijas, kas noteiktu to, kā veicama pacientu ar pagaidu traheostomu aprūpe, kas ir īpaši svarīgi COVID-19 pandēmijas apstākļos, kad nav iespējams veikt manipulācijas ierastajā kārtībā. Darba mērķis ir noskaidrot nozīmīgākos aprūpes principus pacientiem ar pagaidu traheostomu intensīvās terapijas nodaļā. Pētījuma uzdevumi ir: 1) analizēt Virdžīnijas Hendersones teoriju un tās praktisko pielietojumu; 2) apkopot un analizēt literatūras avotus par ieteikumiem pacientu ar traheostomu aprūpei; 3) veikt intervijas proto…