Search results for "NOGEL"
showing 10 items of 121 documents
Nanohydrogel Formation within the Halloysite Lumen for Triggered and Sustained Release
2018
An easy strategy to obtain nanohydrogels within the halloysite nanotube (HNTs) lumen was investigated. Inorganic reverse micelles based on HNTs and hexadecyltrimethylammonium bromides were dispersed in chloroform, and the hydrophilic cavity was used as a nanoreactor to confine the gel formation based on alginate cross-linked by calcium ions. Spectroscopy and electron microscopy experiments proved the confinement of the polymer into the HNT lumen and the formation of calcium-mediated networks. Biological tests proved the biocompatibility of the hybrid hydrogel. The nanogel in HNTs was suitable for drug loading and sustained release with the opportunity of triggered burst release by chemical …
Numerical simulations of the kinetics of pulsed electron beam induced synthesis of nanogels in dilute aqueous polymer solutions
2018
Nanogel can be produced by irradiation of dilute aqueous polymer solutions. The nanogels are formed primarily through intramolecular radical-radical crosslinking reactions between two polymer radical sites.
About entangled networks of worm-like micelles: a rejected hypothesis
1996
We report new results from small-angle neutron scattering on d(1 2)-cyclohexane/lecithin/water micellar solutions performed as a function of the water content (w(o)), temperature (T) and dispersed phase volume fraction (phi). The data from dilute samples are interpretable in terms of the existence of giant cylindrical reverse micelles and are well fit with a core-shell model (that provides the micelle structure and dimensions) with values of 28 and 45 Angstrom for the inner core and the outer shell radii, almost independent on temperature and concentration. Such a result could appear consistent with the current idea that worm-like micelles are living polymers. On the contrary, the appearanc…
Two components organogels as molecular recognition systems: properties, behavior and future applications
Diimidazolium-based organic salts as low molecular weight hydro- and organogelator
Synthesis of new fluorinated low molecular weight (LMW) gelators
2011
On the nature of macroradicals formed upon radiolysis of aqueous poly(N-vinylpyrrolidone) solutions
2020
In this work we have explored the nature of macroradicals formed upon radiolysis of aqueous poly(N-vinylpyrrolidone) (PVP) solutions using pulse radiolysis, density functional theory (DFT) and literature data. On the basis of literature data on site-specific kinetics of hydrogen abstraction from simple amides and spectra corresponding to specific radical sites on the same amides we have assessed the distribution of H-atom abstraction by `OH radicals from different positions on the pyrrolidone ring and the polymer backbone. Pulse radiolysis experiments performed at different doses per pulse and different PVP concentrations demonstrate that the H-abstracting radiolysis products are not quanti…
Oligonucleotide-decorated carboxyl-modified PVP nanogels: a new platform for diagnosis and gene-therapy.
2012
Nanogels, or nanoscalar chemically crosslinked polymer networks, were generated by simultaneous crosslinking of Poly(N-vinyl pyrrolidone) (PVP) and grafting of acrylic acid (AA) monomer through e-beam irradiation of their aqueous solutions. The yield of the process is very high and no separation or complex purification procedures are required since no recourse to surfactants or organic solvents is made. The administered irradiation dose (40 kGy) imparts also sterility to the obtained nanogels in the form of aqueous dispersions. Control of particle size and size-distribution can be achieved by proper selection of the irradiation conditions. In particular, we obtained nanogel variants with av…
Multi-Functional Nanogels for Tumor Targeting and Redox-Sensitive Drug and siRNA Delivery
2016
(1) Background: A new family of nanosystems able to discern between normal and tumor cells and to release a therapeutic agent in controlled way were synthetized by e-beam irradiation. This technique permits to obtain biocompatible, sterile, carboxyl-functionalized polyvinylpyrrolidone (PVP-co-acrylic acid) nanogels (NGs); (2) Methods: Here, we performed a targeting strategy based on the recognition of over-expressed proteins on tumor cells, like the folate receptor. The selective targeting was demonstrated by co-culture studies and flow cytometry analysis, using folate conjugated NGs. Moreover, nanoparticles were conjugated to a chemotherapeutic drug or to a pro-apoptotic siRNA through a gl…