Search results for "NOS-I"

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Hippocampal overexpression of Nos1ap promotes endophenotypes related to mental disorders

2021

Abstract Background Nitric oxide synthase 1 adaptor protein (NOS1AP; previously named CAPON) is linked to the glutamatergic postsynaptic density through interaction with neuronal nitric oxide synthase (nNOS). NOS1AP and its interaction with nNOS have been associated with several mental disorders. Despite the high levels of NOS1AP expression in the hippocampus and the relevance of this brain region in glutamatergic signalling as well as mental disorders, a potential role of hippocampal NOS1AP in the pathophysiology of these disorders has not been investigated yet. Methods To uncover the function of NOS1AP in hippocampus, we made use of recombinant adeno-associated viruses to overexpress muri…

MaleMedicine (General)Research paperDendritic spineEndophenotypesNOS1APGene ExpressionHippocampusnNOS610 Medicine & healthNitric Oxide Synthase Type IHippocampal formationBiologyHippocampusSpatial memoryGeneral Biochemistry Genetics and Molecular BiologyMiceGlutamatergicR5-920NOS1APnitric oxideCAPONAnimalsNOS-I610 Medicine & healthAdaptor Proteins Signal TransducingMental DisordersRGeneral MedicineGlutamatergic postsynaptic densityNeuropsychopharmacologyDisease Models Animalpsychiatric disordersGene Expression Regulationnervous systemMedicineDisease SusceptibilityDisks Large Homolog 4 ProteinNeuroscienceBiomarkersProtein BindingSignal Transduction

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