Search results for "NPL"
showing 10 items of 45 documents
Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes.
2020
Background: Naturally occurring variation in Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), encoding for an enzyme involved in phosphatidylinositol acyl-chain remodelling, has been associated with fatty liver and hepatic disorders. Here, we examined the relationship between hepatic Mboat7 down-regulation and fat accumulation. Methods: Hepatic MBOAT7 expression was surveyed in 119 obese individuals and in experimental models. MBOAT7 was acutely silenced by antisense oligonucleotides in C57Bl/6 mice, and by CRISPR/Cas9 in HepG2 hepatocytes. Findings: In obese individuals, hepatic MBOAT7 mRNA decreased from normal liver to steatohepatitis, independently of diabetes, inflammatio…
Cicatrici: El secreto de sus ojos di Sacheri e Campanella
2012
In 2005 the Argentinian writer Eduardo Sacheri published The Question in Their Eyes (La pregunta de sus ojos). The novel narrates on a double level, both fictional and temporal, the decision of a retired prosecutor to come to terms with a case of rape and murder which had taken place years earlier: his life had been shattered by the consequences of that tragedy, and writing about it would be a way to start living again. The director Juan José Campanella - widely famous for having directed episodes of the television series Law & Order, but especially as the director of successful films such as El hijo de la novia - decided to adapt the novel and involved Sacheri in the project: the close c…
Npl3 stabilizes R-loops at telomeres to prevent accelerated replicative senescence.
2019
Abstract Telomere shortening rates must be regulated to prevent premature replicative senescence. TERRA R‐loops become stabilized at critically short telomeres to promote their elongation through homology‐directed repair (HDR), thereby counteracting senescence onset. Using a non‐bias proteomic approach to detect telomere binding factors, we identified Npl3, an RNA‐binding protein previously implicated in multiple RNA biogenesis processes. Using chromatin immunoprecipitation and RNA immunoprecipitation, we demonstrate that Npl3 interacts with TERRA and telomeres. Furthermore, we show that Npl3 associates with telomeres in an R‐loop‐dependent manner, as changes in R‐loop levels, for example, …
The effects of mental rotation on computational thinking
2019
Abstract Although several investigations of spatial reasoning and mental rotation skills have been conducted in research areas linked to STEM education, to the best of our knowledge, few of these studies have examined the relationship between spatial reasoning and computational thinking. Given this gap in the literature, the present study investigates the role and action of spatial reasoning, and specifically the effects of mental rotation on computational thinking within an embodied and enacted perspective. To achieve this, we carried out a study involving 92 students in five primary-school classes (1st grade - 5th grade). The findings reveal a positive correlation between computational th…
RUOLO DEL POLIMORFISMO ILE148MET DEL GENE PNPLA3 NELLA STEATOSI ASSOCIATA ALLA IPOBETALIPOPROTEINEMIA FAMILIARE
2014
Ruolo del gene PNPLA3 nella suscettibilità genetica della suscettibilità genetica della steatosi epatica
Theoretical Evaluation of [V IV (α-C 3 S 5 ) 3 ] 2– as Nuclear-Spin-Sensitive Single-Molecule Spin Transistor
2017
In a straightforward application of molecular nanospintronics to quantum computing, single-molecule spin transistors can be used to measure nuclear spin qubits. Conductance jumps accompany electronic spin flips at the so-called anticrossings between energy levels, which take place only at specific magnetic fields determined by the nuclear spin state. To date, the only molecular hardware employed for this technique has been the terbium(III) bis(phthalocyaninato) complex. Here we explore theoretically whether a similar behavior is expected for a highly stable molecular spin qubit, the vanadium tris-dithiolate complex [VIV(α-C3S5)3]2–. We consider such a molecule between two gold electrodes an…
The balance sheet accounts on the stress tests
2017
Este artículo estudia la influencia de la estructura del balance en la PD (probabilidad de incumplimiento) y LGD (pérdida dada por defecto) utilizando modelos econométricos. El objetivo es estudiar cómo afectan los agregados en el balance general a la DP y la LGD, distinguiendo estos efectos según el ciclo económico, de modo que se puedan aplicar a la prueba de resistencia. Los resultados indican que la estructura del saldo es importante en PD y LGD, especialmente con respecto a los fondos de los accionistas, los recursos del BCE y la cuenta de activos no corrientes mantenidos para la venta. También destaca la influencia del ciclo económico y el diferente comportamiento de la DP y la LGD co…
IL28B and PNPLA3 Polymorphisms Affect Histological Liver Damage in Patients with Non-alcoholic Fatty Liver Disease.
2012
Background & Aims: Genetic background may affect liver damage in patients with non-alcoholic fatty liver disease (NAFLD). The main outcomes of the study were to assess whether IL28B rs12979860 and rs8099917 polymorphisms, together with PNPLA3 rs738409 C>G polymorphism, are associated with lobular inflammation and fibrosis, in NAFLD patients. Methods: One hundred sixty consecutive NAFLD patients were assessed by liver biopsy (Kleiner score); anthropometric, and biochemical and metabolic features were included. IL28B rs12979860 C>T, IL28B rs8099917 G>C, and PNPLA3 rs738409 C>G single nucleotide polymorphisms were tested. Results: Seventy-four (46.2%) patients had IL28B rs12979860 CC polymorph…
Uzņēmuma "Flora" lietu interneta projekts
2018
Lietu interneta nozarē ir viena no aktuālākām un strauji attīstītākām informācijas tehnoloģiju tēmām. Izmantojot lietu interneta koncepciju un saistītas tehnoloģijas ir iespējams efektīvāk veikt biznesa procesus, paaugstināt produkcijas un pakalpojumu kvalitāti, kā arī nodrošināt augstāko drošības līmeni. Diplomdarba mērķis ir izstrādāt automatizētu sistēmu vides datu (temperatūra, mitrums, gaisma, augsnes auglības līmenis) nolasīšanai uzņēmumā “Flora”. Projektam tika izveidota koncepcija, kas aptver svarīgākus projekta aspektus: grafiks, budžets, tehniskā informācija un noteikti ierobežojumi. Balstoties uz koncepciju, tika veikta projekta realizācija, kurā laikā, pirmkārt, izstrādāts risin…