Search results for "NPS"
showing 10 items of 116 documents
CLINICAL, BIOMOLECULAR AND IMMUNOLOGICAL INVESTIGATION OF KNEE OSTEOARTHRITIS
2014
Introduction. Osteoarthritis (OA) is a slowly progressive disorder characterized by a gradual loss of articular cartilage. The OA classification is mainly based on clinical and radiographic evaluations, using the Knee Society Score (AKSS) and the Kellgren and Lawrence (KL) scale. Single nucleotide polymorphisms (SNPs) in frzb, matn3,aspn, pthr2, gdf5 and dvwa genes are involved in OA susceptibility. However, very few studies in Caucasian people describe the association between KL grading scale and genetical alterations. In this study we assessed the associations between KL grade, clinical features,SNPs and inflammatory mediators in Sicilian individuals Methods. We enrolled 66 patients with …
Il vincolo di affinità profonda. Verso una filosofia ambientale panpsichista
2022
The article provides some arguments in favour of a panpsychist turn in environmental philosophy. It first explains why dualism remains a favoured polemical target for many environmental activists and theorists, even though the scientific/metaphysical paradigm of reference is now generally physicalist. It then points to some of the tribulations of environmental philosophy in juggling dualism and physicalism. It goes on to describes some of the strategies adopted by environmental philosophers to establish an axiologically-relevant ontological affinity between humans and non-humans, and notes how these strategies punctually (and more or less explicitly and plausibly) return to the recognition …
Age and Cytokine Gene Variants Modulate the Immunogenicity and Protective Effect of SARS-CoV-2 mRNA-Based Vaccination
2023
The introduction of anti-SARS-CoV-2 vaccines in late 2020 substantially changed the pandemic picture, inducing effective protection in the population. However, individual variability was observed with different levels of cellular response and neutralizing antibodies. We report data on the impact of age, gender, and 16 single nucleotide polymorphisms (SNPs) of cytokine genes on the anti-SARS-CoV-2 IgG titers measured 31 and 105 days after administration of the second dose of BNT162b2 vaccine to 122 healthy subjects from the health care staff of the Palermo University Hospital, Italy. The higher titers at 31 days were measured in the younger subjects and in subjects bearing T-positive genotyp…
Normativity all the way down: from normative realism to pannormism
2017
In this paper, I will give an argument for what I call pannormism, the view according to which if x instantiates a metaphysically basic normative property F, then whatever grounds the being of x also instantiates F. In slogan form: if there is normativity, there is normativity all the way down. Such pannormism is in many ways analogous to panpsychism, and my discussion also contains an important lesson for panpsychism, a way to avoid its so-called combination problem. In Sect. 1, I present the argument; in Sect. 2, I discuss its conclusion.
Panpsychism, The Combination Problem, and Plural Collective Properties
2018
ABSTRACTPanpsychism claims that each fundamental entity is conscious, but then faces the problem of how such entities combine to make up our ordinary consciousness. In this paper, I show how panpsy...
Genome‐wide survey on three local horse populations with a focus on runs of homozygosity pattern
2022
Purosangue Orientale Siciliano, Sanfratellano and Siciliano represent the Sicilian equine genetic resource. This study aimed to investigate the genetic diversity, population structure and the pattern of autozygosity of Sicilian horse populations using genome-wide single-nucleotide polymorphism (SNP) data generated with the Illumina Equine SNP70 array. The genotyping data of 17 European and Middle East populations were also included in the study. The patterns of genetic differentiation, model-based clustering and Neighbour-Net showed the expected positioning of Sicilian populations within the wide analysed framework and the close connections between the Purosangue Orientale Siciliano and the…
Signs of local adaptation by genetic selection and isolation promoted by extreme temperature and salinity in the Mediterranean seagrass Posidonia oce…
2023
Adaptation to local conditions is known to occur in seagrasses; however, knowledge of the genetic basis underlying this phenomenon remains scarce. Here, we analysed Posidonia oceanica from six sites within and around the Stagnone di Marsala, a semi-enclosed coastal lagoon where salinity and temperature exceed the generally described tolerance thresholds of the species. Sea surface temperatures (SSTs) were measured and plant samples were collected for the assessment of morphology, flowering rate and for screening genome-wide polymorphisms using double digest restriction-site-associated DNA sequencing. Results demonstrated more extreme SSTs and salinity levels inside the lagoon than the outer…
Adaptation to Low Salinity Promotes Genomic Divergence in Atlantic Cod (Gadus morhua L.).
2015
How genomic selection enables species to adapt to divergent environments is a fundamental question in ecology and evolution. We investigated the genomic signatures of local adaptation in Atlantic cod (Gadus morhua L.) along a natural salinity gradient, ranging from 35‰ in the North Sea to 7‰ within the Baltic Sea. By utilizing a 12 K SNPchip, we simultaneously assessed neutral and adaptive genetic divergence across the Atlantic cod genome. Combining outlier analyses with a landscape genomic approach, we identified a set of directionally selected loci that are strongly correlated with habitat differences in salinity, oxygen, and temperature. Our results show that discrete regions within the …
Caratterizzazione genomica delle razze bovine autoctone italiane
2018
Negli ultimi cinquant'anni, a causa della sostituzione con le razze cosmopolite, le razze zootecniche locali hanno subito una forte contrazione numerica. Tuttavia, esse rappresentano un’importante patrimonio, in grado, tra le altre cose, di valorizzare ambienti marginali. Sono spesso legate anche a produzioni tipiche di alta qualità. La loro caratterizzazione rappresenta un passo essenziale verso eventuali piani di recupero, conservazione e valorizzazione. Il presente studio è stato condotto al fine di caratterizzare a livello genomico le razze bovine locali allevate in Italia. Sono stati campionati un totale di 814 animali appartenenti a 30 razze italiane e a 2 razze cosmopolite (Charolais…
Genome wide Copy Number Variation (CNV) detection in Cinisara cattle breed
2017
Copy Number Variations (CNVs) are classes of polymorphic genomic regions including deletions, duplications and insertions of DNA fragments from at least 0.5 kb up to several Mb. CNV represents an important source of genetic variability that provides genomics structural information complementary to the single nucleotide polymorphism (SNP) data. Some CNVs have been shown to be important in both normal phenotypic variability and disease susceptibility in livestock. Several approaches to identify CNVs including FISH, aCGH, SNP array or NGS, were proposed and among these SNP genotyping is relatively low cost, high-throughput and high coverage method. The aim of this study was to identify the CNV…