Search results for "NTD"
showing 10 items of 19 documents
Projekts: Uzņēmuma SIA "Click&Repair" dibināšana
2019
Maģistra darba ideja ir izveidot digitālu platformu mājaslapas un aplikācijas formā, kas nodrošinās vidi apavu, somu un apģērbu remonta pakalpojuma sniedzējiem un to klientiem. Projekta galvenais mērķis ir realizēt ideju, nodibinot uzņēmumu, kas spēs atmaksāt ieguldītos finanšu līdzekļus, gūs peļņu, sabiedrībai nodrošinās kvalitatīvu, ātru un ērtu pakalpojumu, kā arī veicinās kopējās nozares attīstību. Lai sasniegtu projektā noteikto mērķi, darba ietvaros tiek veikta uzņēmuma saimnieciskās darbības uzsākšanai un attīstībai nepieciešamo plānu izstrāde. Gan platformas, gan paša uzņēmums nosaukums – “Click&Repair”. Projekta pirmajā nodaļā ir analizēta biznesa ideja un tās aktualitāte, pamatojo…
Studio di validazione dell'ACE-R in lingua italiana nella popolazione degli young-old e degli old-old
2012
Introduction. The main aims of the study were the translation into Italian, and validation subsequently of the Addenbrooke's Cognitive Examination Revised (ACE-R), and the evaluation of its usefulness in discriminating cognitively normal subjects from patients with mild dementia. Methods. The ACE-R was translated and adapted into Italian. The Italian ACE-R was administrated to a group of 179 elderly subjects (72 cognitively intact and 107 subjects with mild dementia, mean age 75.4 years ± 6.4). The group was stratified in two sub-samples according to age, i.e. young-old (< 75 years) and old-old (≥ 75 years), in order to evaluate test's sensitivity and specificity in detecting dementia among…
Let the countdown begin — Aging experiences of young adults in countdown blogs
2012
Abstract This paper examines a particular blog phenomenon that has not yet received much attention: Countdown blogs which are written before a significant birthday (in this paper, it is the thirtieth birthday). The bloggers fill the remaining time, often a year, with the accomplishment of particular tasks, reflections on their lives or photo projects. In their blogs, the young adults demonstrate an age awareness that is often overlooked in aging studies. The paper argues that young adults use countdown blogs to cope with their aging experiences and, in doing so, they apply a particular economic rhetoric and emerge as entrepreneurs of themselves – an identity concept that Foucault presented …
Fabrication of Bismuth Absorber Arrays for NTD-Ge Hard X-ray Microcalorimeters
2020
The high-spectral-resolution detection of hard X-rays (E > 20 keV) is a challenging and nearly unexplored area in space astrophysics. Traditionally hard X-ray detectors present moderate spectral resolutions, although few tens of eV one could open new frontiers in the study of nuclear processes and high-temperature plasma dynamics in energetic processes. This can be achieved by using cryogenic microcalorimeters. Within a research activity aimed at developing arrays of neutron transmutation-doped germanium (NTD-Ge) microcalorimeters for the high-spectral-resolution detection (about 50 eV@60 keV) of hard X-rays (20 keV < E<100 keV), we developed an electroplating process to fabricate …
Guinea Worm Disease: A Neglected Diseases on the Verge of Eradication
2022
Background: Dracunculiasis, also known as Guinea worm disease (GWD), is a neglected tropical disease (NTD) caused by a parasite (Dracunculus medinensis). In the past, dracunculiasis was known as “the disease of the empty granary” because of the difficulties patients had in going to work in fields or to school when affected by this disease. In tropical areas, the condition has been widespread in economically disadvantaged communities, and has been associated with reduced economic status and low levels of education. Methods: we searched PubMed, Scopus, Google Scholar, EMBASE, Cochrane Library, and WHO websites for literature addressing dracunculiasis published in the last 50 years. Results: b…
Neonatal ten-year retrospective study on neural tube defects in a second level University Hospital
2020
Abstract Background Aim of this retrospective study was to describe clinical characteristics, diagnostic work-up, management and follow-up of newborns with neural tube defects (NTDs), admitted to the Mother and Child Department of the University Hospital of Palermo, in a ten years period. Methods The medical records of 7 newborns (5 males and 2 females) admitted, over a 10-year period from January 2010 to March 2020, to our Department on the first day of life were reviewed. Analyzed data were related to familiar and/or maternal risk factors (consanguinity, maternal preexisting and/or gestational diseases, exposure to teratogen/infectious agents, lack of preconception folic acid supplement),…
Electroplated bismuth absorbers for planar NTD-Ge sensor arrays applied to hard x-ray detection in astrophysics
2018
Single sensors or small arrays of manually assembled neutron transmutation doped germanium (NTD-Ge) based microcalorimeters have been widely used as high energy-resolution detectors from infrared to hard X-rays. Several planar technological processes were developed in the last years aimed at the fabrication of NTD-Ge arrays, specifically designed to produce soft X-ray detectors. One of these processes consists in the fabrication of the absorbers. In order to absorb efficiently hard X-ray photons, the absorber has to be properly designed and a suitable material has to be employed. Bismuth offers interesting properties in terms of absorbing capability, of low heat capacity (needed to obtain h…
Structure, interdomain dynamics, and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes
2021
AbstractRhodesain is the lysosomal cathepsin L-like cysteine protease ofT. brucei rhodesiense, the causative agent of Human African Trypanosomiasis. The enzyme is essential for the proliferation and pathogenicity of the parasite as well as its ability to overcome the blood-brain barrier of the host. Lysosomal cathepsins are expressed as zymogens with an inactivating pro-domain that is cleaved under acidic conditions. A structure of the uncleaved maturation intermediate from a trypanosomal cathepsin L-like protease is currently not available. We thus established the heterologous expression ofT. brucei rhodesiensepro-rhodesain inE. coliand determined its crystal structure. The trypanosomal pr…
The constellation-X focal plane microcalorimeter array: An NTD-germanium solution
2002
The hallmarks of Neutron Transmutation Doped (NTD) germanium cryogenic thermistors include high reliability, reproducibility, and long term stability of bulk carrier transport properties. Using micro-machined NTD Ge thermistors with integral “flying” leads, we can now fabricate two-dimensional arrays that are built up from a series of stacked linear arrays. We believe that this modular approach of building, assembling, and perhaps replacing individual modules of detectors is essential to the successful fabrication and testing of large multi-element spectrometers. Details of construction are presented.
X-ray and gamma-ray astronomy with NTD germanium-based microcalorimeters
2002
We report on the performance of our NTD-Ge microcalorimeters. To date, the spectral resolution for x-ray and gamma-ray lines from radioactive sources and laboratory plasmas is 4.8 eV in the entire 1 - 6 keV band and 52 eV at 60 keV. Technical details responsible for this performance are presented as well as an innovative electro-thermal approach for enhancing count-rate capability.