Search results for "Nanodevice"

showing 7 items of 17 documents

Nanosensor for Sensitive Detection of the New Psychedelic Drug 25I-NBOMe.

2020

[EN] This work reports the synthesis, characterization, and sensing behavior of a hybrid nanodevice for the detection of the potent abuse drug 25I-NBOMe. The system is based on mesoporous silica nanoparticles, loaded with a fluorescent dye, functionalized with a serotonin derivative and capped with the 5-HT2A receptor antibody. In the presence of 25I-NBOMe the capping antibody is displaced, leading to pore opening and rhodamine B release. This delivery was ascribed to 5-HT2A receptor antibody detachment from the surface due to its stronger coordination with 25I-NBOMe present in the solution. The prepared nanodevice allowed the sensitive (limit of detection of 0.6 mm) and selective recogniti…

SerotoninMesoporous silica nanoparticles25I-NBOMehallucinogenic drugsMescalinesensorsCatalysischemistry.chemical_compoundAgonist 5-HT2A serotonin receptorQUIMICA ORGANICAQUIMICA ANALITICAmedicineRhodamine BHumansmesoporous silica nanoparticlesNanodeviceLysergic acid diethylamideDetection limitSensorsQUIMICA INORGANICAOrganic ChemistryMDMAGeneral ChemistryMesoporous silicaHallucinogenic drugs25I-NBOMeCombinatorial chemistrychemistryDimethoxyphenylethylamine25I-NBOMe agonist 5-HT2A serotonin receptor hallucinogenic drugs mesoporous silica nanoparticles sensorsHallucinogensagonist 5-HT2A serotonin receptormedicine.drug
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NEW GENERATION OF BIOCOMPATIBLE GRAFT COPOLYMERS FOR THE PRODUCTION OF NANODEVICES

2009

Settore CHIM/09 - Farmaceutico Tecnologico Applicativobiocompatible copolymers nanodevices
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Information Processing Schemes Based on Monolayer Protected Metallic Nanoclusters

2011

Nanostructures are potentially useful as building blocks to complement future electronics because of their high versatility and packing densities. The fabrication and characterization of particular nanostructures and the use of new theoretical tools to describe their properties are receiving much attention. However, the integration of these individual systems into general schemes that could perform simple tasks is also necessary because modern electronics operation relies on the concerted action of many basic units. We review here new conceptual schemes that can allow information processing with ligand or monolayer protected metallic nanoclusters (MPCs) on the basis of the experimentally de…

Signal processingMaterials scienceBiomedical EngineeringBioengineeringNanotechnologyGeneral ChemistryContent-addressable memoryCondensed Matter PhysicsNanoclustersLogic gateScalabilityGeneral Materials ScienceElectronicsNanodeviceParallel arrayJournal of Nanoscience and Nanotechnology
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Rapid and eco-friendly synthesis of graphene oxide-silica nanohybrids

2014

The increasing interest in Graphene oxide (GO) is due to many issues: the presence of both sp2-conjugated atoms and oxygen-containing functional groups provides a strong hydrophilicity and the possibility to further functionalize it with other molecules (i.e. π-π interactions covalent attachment etc.) [1]. Furthermore since the GO is biocompatible and noncytotoxic many studies have been recently focused on the development of GO-based nanodevices for bioimaging DNA detection drug delivery. Due to their low cytotoxicity and large internal surface area silica nanoparticles have been taken into account as promising material for biolabeling and drug loading/delivery. Particular consideration has recently been demonstrated for GO-silica composites because of the potentialities for electrical applications their chemical inertia and stability toward ions exposure. The possibility to combine the extraordinary properties of GO and silica offers several advantages for the realization of nanoprobes for biological applications and of biosensor [12]. The strategy for the fabrication of GO-nanosilica nanohybrids can be schematized as follows: (i) synthesis of GO by oxidizing graphite powder with the method described by Marcano et al. [3] (ii) Preparation of oxygen-loaded silica nanoparticles by thermal treatments in controlled atmosphere in order to induce high NIR emission at 1272 nm from high purity silica nanoparticles. (iii) preparation of GrO-silica nanohybrid films via rapid solvent casting in water. The nanohybrids were tested by XPS FTIR Raman analysis UV photoluminescence analysis TGA Zeta potential measurements electrical tests AFM and SEM. Several nanohybrids were prepared by combining two different typologies of GO and two different samples of silica.
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Metal ion affinity-based biomolecular recognition and conjugation inside synthetic polymer nanopores modified with iron-terpyridine complexes.

2011

Here we demonstrate a novel biosensing platform for the detection of lactoferrin (LFN) via metal-organic frameworks, in which the metal ions have accessible free coordination sites for binding, inside the single conical nanopores fabricated in polymeric membrane. First, monolayer of amine-terminated terpyridine (metal-chelating ligand) is covalently immobilized on the inner walls of the nanopore via carbodiimide coupling chemistry. Second, iron-terpyridine (iron-terPy) complexes are obtained by treating the terpyridine modified-nanopores with ferrous sulfate solution. The immobilized iron-terPy complexes can be used as recognition elements to fabricate biosensing nanodevice. The working pri…

chemistry.chemical_classificationLigandPolymersPyridinesSurface PropertiesMetal ions in aqueous solutionIronInorganic chemistrytechnology industry and agricultureGeneral ChemistryBiosensing TechniquesBiochemistryCombinatorial chemistryCatalysisNanoporechemistry.chemical_compoundLactoferrinNanoporesColloid and Surface ChemistrychemistryMonolayerNon-covalent interactionsTerpyridineNanodeviceBiosensorJournal of the American Chemical Society
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Thermodynamics and Biophysics of Biomedical Nanosystems Applications and Practical Considerations

2019

This book highlights the recent advances of thermodynamics and biophysics in drug delivery nanosystems and in biomedical nanodevices. The up-to-date book provides an in-depth knowledge of bio-inspired nanotechnological systems for pharmaceutical applications. Biophysics and thermodynamics, supported by mathematics, are the locomotive by which the drug transportation and the targeting processes will be achieved under the light of the modern pharmacotherapy. They are considered as scientific tools that promote the understanding of physicochemical and thermotropic functionality and behavior of artificial cell membranes and structures like nanoparticulate systems. Therefore, this book focusses …

drug delivery nanosystemsnanothermodynamicsbiomedical nanodeviceslipid thermodynamicslipid membranesnano thermotropic behaviorliposomal formulananoparticle stability
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PHARMACEUTICAL NANODEVICES FOR BIOMEDICAL APPLICATIONS

2013

nanodevices
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