Search results for "Native"
showing 10 items of 1727 documents
Isolation and characterization of haemoporin, an abundant haemolymph protein from Aplysia californica.
2003
In the present study, we show the isolation and characterization of the protein haemoporin, which constitutes the second most abundant protein fraction in the haemolymph of the marine gastropod Aplysia californica. Although Aplysia is commonly used to investigate the molecular basis of learning, not much is known about the proteins in its haemolymph, which is in contact with the neurons owing to the open circulatory system of molluscs. In the native state, haemoporin is a macromolecular complex forming a cylinder with a central solvent-filled pore. The native complex most probably is a homopentamer made up from 70 kDa subunits with a molecular mass of 360 kDa and a sedimentation coefficient…
El sistema linfático: el gran olvidado del sistema circulatorio.
2014
En el presente artículo se analizan los modelos mentales y las concepciones alternativas que tienen los estudiantes de distintos niveles educativos sobre el sistema linfático como componente del sistema circulatorio. Se establece una relación con las dificultades que se salvaron a lo largo de la historia en la adquisición de dichos conocimientos. Los resultados muestran una deficiente relación entre los sistemas linfáticos y sanguíneos, una falta de conocimientos tanto anatómicos como fisiológicos del sistema linfático y una dificultad para ampliar el modelo explicativo del transporte de nutrientes en los organismos animales, exclusivamente centrado en el sistema sanguíneo. Se termina ofrec…
The Role of the Classical Pathway for the Bactericidal Effect of Normal Sera Against Gram-Negative Bacteria
1985
Many gram-negative bacteria are killed after treatment with normal serum. This phenomenon was already described in 1889 by Buchner. The serum-bactericidal effect is abolished when serum has been incubated for 30 min at 56° C. Gram-positive bacteria are less sensitive than gram-negative bacteria to direct killing, although gram-positive cocci are opsonized by the action of serum mediated by antibodies and complement (Inoue et al. 1968; Johnston et al. 1969). Normal sera exhibit bactericidal and bacteriolytic properties against some gramnegative strains; whereas, other gram-negative strains are serum resistant. It has been shown that serum from C4-deficient guinea pigs is able to kill some gr…
Interaction of Bacterial Endotoxin (LPS) with Fluid Phase and Macrophage Membrane Associated C1q, the FC-Recognizing Component of the Complement Syst…
1990
The bactericidal activity of normal serum was first described by Buchner in 1889 (10). This effect is abolished when serum has been incubated for 30 min at 56°C. Gram positives are less sensitive than Gram negative bacteria to direct killing, although gram positive cocci are opsonized by the action of serum mediated by antibodies and complement (22). It was found that most of the smooth strains of gram negative bacteria are serum resistant; whereas, the corresponding rough forms are extremely serum sensitive (32, 37). Thus evidence was provided that the composition of the bacterial surface may influence the reaction of the bacteria with the lytic system. The bacteriolytic properties of seru…
Complement activation and innate immunity
2007
Indefinitely stable iron(IV) cage complexes formed in water by air oxidation
2017
In nature, iron, the fourth most abundant element of the Earth's crust, occurs in its stable forms either as the native metal or in its compounds in the +2 or +3 (low-valent) oxidation states. High-valent iron (+4, +5, +6) compounds are not formed spontaneously at ambient conditions, and the ones obtained synthetically appear to be unstable in polar organic solvents, especially aqueous solutions, and this is what limits their studies and use. Here we describe unprecedented iron(IV) hexahydrazide clathrochelate complexes that are assembled in alkaline aqueous media from iron(III) salts, oxalodihydrazide and formaldehyde in the course of a metal-templated reaction accompanied by air oxidation…
Critical evaluation of the scientific content in clinical practice guidelines
2015
Meeting Report: The 11th International Conference on Differentiation Therapy and Innovative Therapeutics in Oncology
2007
The International Conference on Differentiation Therapy group of clinicians and researchers has met for more than 20 years and the most recent meeting in 2005 was held in Shanghai, China ( [1][1]). This group fostered the required networks to translate these novel strategies to clinical practice, as