Search results for "Nautilus"
showing 10 items of 12 documents
Nacre evolution: a proteomic approach.
2009
AbstractFrom an evolutionary viewpoint, the molluscan nacre constitutes a fascinating object. This microstructure appeared early, in the Lower Cambrian period, about 530 million years ago, and since then, has been kept unchanged until today. Nacre is restricted to the conchiferan mollusks, where it occurs in t least three main classes, bivalves, gastropods and cephalopods. The aim of the present study is to investigate whether all nacres are built from the same “macromolecular tools”, proteins of the nacre matrix. To this end, we studied three new nacre models, the freshwater bivalve Unio pictorum, the cephalopod Nautilus macromphalus, and the gastropod Haliotis asinina, to which we applied…
8 Å cryo-TEM and single particle analysis of Nautilus pompilius hemocyanin under two states of oxygenation
2007
Extended abstract of a paper presented at MC 2007, 33rd DGE Conference in Saarbrücken, Germany, September 2 – September 7, 2007
Integration of lot sizing and safety strategy placement using interactive multiobjective optimization
2022
We address challenges of unpredicted demand and propose a multiobjective optimization model to integrate a lot sizing problem with safety strategy placement and optimize conflicting objectives simultaneously. The novel model is devoted to a single-item multi-period problem in periodic review policy. As a safety strategy, we use the traditional safety stock concept and a novel concept of safety order time, which uses a time period to determine the additional stock to handle demand uncertainty. The proposed model has four objective functions: purchasing and ordering cost, holding cost, cycle service level and inventory turnover. We bridge the gap between theory and a real industrial problem a…
A new preference handling technique for interactive multiobjective optimization without trading-off
2015
Because the purpose of multiobjective optimization methods is to optimize conflicting objectives simultaneously, they mainly focus on Pareto optimal solutions, where improvement with respect to some objective is only possible by allowing some other objective(s) to impair. Bringing this idea into practice requires the decision maker to think in terms of trading-off, which may limit the ability of effective problem solving. We outline some drawbacks of this and exploit another idea emphasizing the possibility of simultaneous improvement of all objectives. Based on this idea, we propose a technique for handling decision maker’s preferences, which eliminates the necessity to think in terms of t…
NAUTILUS method: An interactive technique in multiobjective optimization based on the nadir point
2010
Most interactive methods developed for solving multiobjective optimization problems sequentially generate Pareto optimal or nondominated vectors and the decision maker must always allow impairment in at least one objective function to get a new solution. The NAUTILUS method proposed is based on the assumptions that past experiences affect decision makers’ hopes and that people do not react symmetrically to gains and losses. Therefore, some decision makers may prefer to start from the worst possible objective values and to improve every objective step by step according to their preferences. In NAUTILUS, starting from the nadir point, a solution is obtained at each iteration which dominates t…
Nautilus pompilius Hemocyanin: 9 Å Cryo-EM Structure and Molecular Model Reveal the Subunit Pathway and the Interfaces between the 70 Functional Units
2007
Hemocyanins are giant extracellular oxygen carriers in the hemolymph of many molluscs. Nautilus pompilius (Cephalopoda) hemocyanin is a cylindrical decamer of a 350 kDa polypeptide subunit that in turn is a "pearl-chain" of seven different functional units (FU-a to FU-g). Each globular FU has a binuclear copper centre that reversibly binds one O(2) molecule, and the 70-FU decamer is a highly allosteric protein. Its primary structure and an 11 A cryo-electron microscopy (cryo-EM) structure have recently been determined, and the crystal structures of two related FU types are available in the databanks. However, in molluscan hemocyanin, the precise subunit pathway within the decamer, the inter…
Interactive Multiobjective Optimization in Lot Sizing with Safety Stock and Safety Lead Time
2021
In this paper, we integrate a lot sizing problem with the problem of determining optimal values of safety stock and safety lead time. We propose a probability of product availability formula to assess the quality of safety lead time and a multiobjective optimization model as an integrated lot sizing problem. In the proposed model, we optimize six objectives simultaneously: minimizing purchasing cost, ordering cost, holding cost and, at the same time, maximizing cycle service level, probability of product availability and inventory turnover. To present the applicability of the proposed model, we consider a real case study with data from a manufacturing company and apply the interactive NAUTI…
Evolution des biominéralisations nacrées chez les mollusques : caractérisation moléculaire des matrices coquillières du céphalopode nautiloïde Nautil…
2008
In metazoan, molluscan shells are one of the most fascinating examples for the investigation of the calcium carbonate biomineralization phenomenon. These exoskeletons are secreted by the outer epithelium of the calcifying mantle. They are composed of 95% of mineral – calcite and/or aragonite -, the rest of the shells being constituted by a mixture of proteins, glycoproteins and polysaccharides, called the organic matrix. This calcifying matrix is directly involved in biomineralization. This PhD work is focussed on the characterization of organic components associated to the nacreous layer. In molluscs, the nacre is observed in shells of extent species of bivalves, gastropods, cephalopods an…
On Board the Nautilus
2012
Some months ago, I took part, with some friends, in an astronomy trip to the mountain Pico del Buitre, in Javalambre (province of Teruel, Spain). The trip, among whose participants there were prospective scientists between the age of four and nine, included a night devoted to amateur observation with portable telescopes. El Pico del Buitre is one of the darkest spots in Spain—and also one of the coldest, as all members of the party remember well. Even darker is Roque de los Muchachos, on Las Palmas (Gran Canaria, Canary Islands), one of the most important sites for astronomy observation on the Northern hemisphere.
NAUTILUS framework : towards trade-off-free interaction in multiobjective optimization
2016
In this paper, we present a framework of different interactive NAUTILUS methods for multiobjective optimization. In interactive methods, the decision maker iteratively sees solution alternatives and provides one’s preferences in order to find the most preferred solution. We question the widely used setting that the solutions shown to the decision maker should all be Pareto optimal which implies that improvement in any objective function necessitates allowing impairment in some others. Instead, in NAUTILUS we enable the decision maker to make a free search without having to trade-off by starting from an inferior solution and iteratively approaching the Pareto optimal set by allowing all obje…