Search results for "Neck"

Thermal imaging ruled out as a supplementary assessment in patients with fibromyalgia: A cross-sectional study

2021

Background The diagnosis of fibromyalgia syndrome (FMS) syndrome is often complicated and relies on diagnostic criteria based mostly on the symptoms reported by patients. Implementing objective complementary tests would be desirable to better characterize this population. Objective The purpose of this cross-sectional study was to compare the skin temperature at rest using thermography in women with FMS and healthy women. Methods Eighty-six women with FMS and 92 healthy controls volunteered to participate. The temperature of all participants was measured by infra-red thermography, registering the skin surface temperature (minimum, maximum and average) at rest in different areas: neck, upper…

Real-Time Routing Selection in Flexible Manufacturing Systems

1993

Routing flexibility is one of the main peculiarities of Flexible Manufacturing Systems. This paper proposes three methods for real-time routing selection. The first one makes decisions comparing the current workload of machines in each alternative path. The second method considers the current workloads at the bottleneck machines in each allowed route. The third approach makes real-time decisions minimizing a merit index that represents a measure of the still required resource amount. The index is computed by short discrete-event simulation runs. Some case studies evaluate and compare the proposed approaches.

GOTeC: INTERDISCIPLINARY TUMOR BOARD FOR THE DIAGNOSIS AND TREATMENTS OF HEAD AND NECK CANCERS

2018

Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: the ARCAGE study

2012

ABSTRACT Background The study aimed to investigate the role of medical history (skin warts, Candida albicans, herpetic lesions, heartburn, regurgitation) and medication use (for heartburn; for regurgitation; aspirin) in the aetiology of upper aerodigestive tract (UADT) cancer. Methods A multicentre (10 European countries) case–control study [Alcohol-Related CAncers and GEnetic susceptibility (ARCAGE) project]. Results There were 1779 cases of UADT cancer and 1993 controls. History of warts or C. albicans infection was associated with a reduced risk [odds ratio (OR) 0.80, 95% confidence interval (CI) 0.68–0.94 and OR 0.73, 95% CI 0.60–0.89, respectively] but there was no association with her…

Non-muscle myosin II as a predictive factor in head and neck squamous cell carcinoma

2018

Background The present study attempted to provide information regarding non-muscle myosin II (MII) isoforms immunoreactivity in patients with head and neck squamous cell carcinoma (HNSCC) and analysis of the patients’ clinical status after 5 years of monitoring. Material and Methods A semiquantitative analysis of the immunoreactivity of the MII isoforms was performed in 54 surgical specimens and its correlation with clinical and pathological variables and prognosis was verified. Data were analyzed using chi-square, Mann-Whitney and Kruskal-Wallis tests. To evaluate the survival over the total monitoring time and any connection with the proteins studied, the Kaplan-Meier analysis was used. P…

p53 Gene Therapy

2002

Based on the frequent inactivation of the p53 gene product in human malignancy, and its functional involvement in tumor suppression, cell cycle control and apoptosis, p53 was identified as an attractive target for somatic gene therapy strategies in cancer. Several pilot and phase I studies explored the intratumoral injection of viral expression vectors encoding the p53 cDNA in patients with advanced cancer. These studies confirmed the safety and feasibility of this approach. Further, vector-specific transgene expression and surrogate markers for biological activity of the transgene were demonstrated. Local tumor regression, or stabilization of tumor growth, were observed in some studies, an…

Strong chromatic index of products of graphs

2007

Graphs and Algorithms

Targeting Cancer Chemotherapy Resistance by Precision Medicine-Driven Nanoparticle-Formulated Cisplatin.

2021

Therapy resistance is the major cause of cancer death. As patients respond heterogeneously, precision/personalized medicine needs to be considered, including the application of nanoparticles (NPs). The success of therapeutic NPs requires to first identify clinically relevant resistance mechanisms and to define key players, followed by a rational design of biocompatible NPs capable to target resistance. Consequently, we employed a tiered experimental pipeline fromiin silico/ito analytical andiin vitro/ito overcome cisplatin resistance. First, we generated cisplatin-resistant cancer cells and used next-generation sequencing together with CRISPR/Cas9 knockout technology to identify the ion cha…

Repeated transfer of small RNA virus populations leading to balanced fitness with infrequent stochastic drift

1996

The population dynamics of RNA viruses have an important influence on fitness variation and, in consequence, on the adaptative potential and virulence of this ubiquitous group of pathogens. Earlier work with vesicular stomatitis virus showed that large population transfers were reproducibly associated with fitness increases, whereas repeated transfers from plaque to plaque (genetic bottlenecks) lead to losses in fitness. We demonstrate here that repeated five-plaque to five-plaque passage series yield long-term fitness stability, except for occasional stochastic fitness jumps. Repeated five-plaque passages regularly alternating with two consecutive large population transmissions did not cau…

New archaeological discoveries through magnetic gradiometry: The early Celtic settlement on Mont Lassois, France

2006

The burial complex of the “Lady of Vix” was discovered and excavated in the 1950s at the foot of Mont Lassois (Figure 1), a mountain situated close to the town of Chatillion-sur-Seine in the Bourgogne region of France. The assemblage of the burial goods was rather extraordinary, including such items as an artfully crafted golden necklace with winged horses and a voluminous wine-mixing vessel, probably made in a Greek workshop, capable of holding 1100 liters. According to archaeological research, this member of the aristocracy must have lived during the period between 550 and 500 BCE. Several large-scale geophysical research projects were undertaken in the vicinity of the burial complex duri…