Search results for "Nectin"
showing 10 items of 355 documents
Tenascin gene expression in rat liver and in rat liver cells. In vivo and in vitro studies.
1991
Tenascin is a major glycoprotein constituent of the extracellular matrix with a strong affinity to fibronectin; its distribution is believed to be temporarily and spatially limited. Tenascin gene expression is increased during wound healing processes. As repair mechanisms in chronic liver diseases resemble wound healing we studied tenascin gene expression in rat liver and in isolated rat liver cells. In normal rat liver a tenascin specific antiserum stains sinusoidal cells with fiber-like prolongations, which at the same time are desmin-positive (ITO-cells). In the CCl4-acutely-damaged liver a strong tenascin staining is detected in cells located among the mononuclear cells of the inflammat…
Human recombinant vasostatin-1 may interfere with cell-extracellular matrix interactions
2006
Vasostatin-1 (VS-1), the N-terminal fragment derived from the cleavage of chromogranin A (CgA), has been shown to exert several biological activities on several tissues and organs. Recently, it has been reported that human recombinant VS-1 (STA-CGA(1-78)) may alter myocardial contractility in eel, frog., and rat hearts. In this article we have explored if STA-CGA(1-78) can induce intracellular cascades interacting both with adhesion molecules and/or extracellular matrix (ECM), components, that is, involvement of the heat shock protein 90 (HSP90) and the endothelial NOS (eNOS), known to be implicated in signal transduction mechanisms affecting myocardial contractility. We used 3D cultured ad…
FIBRONECTINA: NUOVO MARKER DI DANNO UROTELIALE NELLA TERAPIA ADIUVANTE INTRAVESCICALE DEI TUMORI VESCICALI NON MUSCOLO INVASIVI
2014
The Fibronectin RGD and synergy sites function in integrin interaction
2018
Fibronectin (FN) is a large glycoprotein component of the extracellular matrix (ECM). It presents two forms: soluble in plasma or insoluble (fibrillar) within the ECM surrounding the cells in tissues. FN is one of the most important proteins in the ECM, it directly mediates cell adhesion, and therefore is essential for several biological processes such as embryonic development or blood clotting. Its involvement in these processes relay in its interaction with the cellular receptors integrins. The major binding site for integrins in FN is the so-called RGD site located in the 10th FN type III repeat (FNIII10), which is recognized by a5b1, aIIbb3 and all the av-containing integrins. Additiona…
A luminal glycoprotein drives dose-dependent diameter expansion of the Drosophila melanogaster hindgut tube
2012
An important step in epithelial organ development is size maturation of the organ lumen to attain correct dimensions. Here we show that the regulated expression of Tenectin (Tnc) is critical to shape the Drosophila melanogaster hindgut tube. Tnc is a secreted protein that fills the embryonic hindgut lumen during tube diameter expansion. Inside the lumen, Tnc contributes to detectable O-Glycans and forms a dense striated matrix. Loss of tnc causes a narrow hindgut tube, while Tnc over-expression drives tube dilation in a dose-dependent manner. Cellular analyses show that luminal accumulation of Tnc causes an increase in inner and outer tube diameter, and cell flattening within the tube wall,…
Protective Effects of a Discontinuous Treatment with Alpha-Lipoic Acid in Obesity-Related Heart Failure with Preserved Ejection Fraction, in Rats
2020
Obesity induces hemodynamic and humoral changes that are associated with functional and structural cardiac remodeling, which ultimately result in the development of heart failure (HF) with preserved ejection fraction (HFpEF). In recent years, pharmacological studies in patients with HFpEF were mostly unsatisfactory. In these conditions, alternative new therapeutic approaches are necessary. The aim of our study was (1) to assess the effects of obesity on heart function in an experimental model and (2) to evaluate the efficacy of an alpha-lipoic acid (ALA) antioxidant treatment. Sprague-Dawley rats (7 weeks old) were either included in the control group (n = 6) or subjected to abdominal aorti…
Adiponectin plasma levels aand chronic kidney disease stages in hypertensive and normotensive subjects
2009
Differences and Similarities in Neuropathy in Type 1 and 2 Diabetes: A Systematic Review
2021
Background: Diabetic neuropathy is defined as the dysfunction of the peripheral nervous system in diabetic patients. It is considered a microvascular complication of diabetes mellitus. Its presence is associated with increased morbidity and mortality. Although several studies have found alterations at somatic motor, sensory levels and at the level of autonomic nervous system in diabetic patients, there is not a systematic approach regarding the differences in neuropathy between the major variants of diabetes, e.g., type 1 and 2 diabetes at both neurological and molecular level. Data sources: we systematically (Medline, Scopus, and Cochrane databases) evaluated the literature related to the …
VALIDITY AND RELIABILITY OF MEASUREMENTS OF THE PARAMETERS OF SMILE AESTHETICS: A COMPARISON BETWEEN DIGITAL AND PLASTER MODELS
2020
This study aims to evaluate the validity and reliability of the TRIOS3 Color intraoral scanner (3Shape A/S, Copenhagen, Denmark) and its associated Ortho Analyzer™ software in measuring parameters of smile aesthetics compared with measurements on plaster casts. The study sample comprised plaster casts and digital models obtained from 30 subjects. Height (H), mesiodistal diameter (MDD) and connecting space (CS) of the anterior teeth were measured with a digital calliper on the plaster models and with the orthodontic software on the digital models. Validity was assessed using a 2-tailed paired t-test; the reliability of measurements for intra-examiner was evaluated with the Intra-class Correl…