Search results for "Negative"
showing 10 items of 1052 documents
Vulnerability to psychotogenic effects of ketamine is associated with elevated D2/3-receptor availability.
2012
Previous positron emission tomography (PET) studies employing competition paradigms have shown either no change or substantial declines in striatal ( 11 C)-raclopride binding after challenge with psychotogenic doses of the N-methyl-D-aspartate antagonist ketamine. We sought to probe the relationship between the severity of ketamine-induced psychotic symptoms and altered dopamine D2/3 receptor availability throughout brain using the high affinity ligand ( 18 F)-fallypride (FP). PET recordings were obtained in a group of 10 healthy, young male volunteers, in a placebo condition, and in the course of an infusion with ketamine at a psychotomimetic dose. Administration of the Positive and Negati…
Vitamin D and clinical symptoms in First Episode Psychosis (FEP): A prospective cohort study
2019
BACKGROUND: There is a paucity of longitudinal research investigating vitamin D in people with early psychosis.METHOD: Vitamin D levels were measured in 168 patients (64% (n = 108) male, mean age 29.3 (9.8) years) with first episode psychosis (FEP), along with measures of clinical state at baseline and at 12 months follow up. We assessed the a) cross sectional, and; b) longitudinal relationships between continuous and categorical 25-hydroxyvitamin D (25(OH)D) levels and clinical symptoms at first contact for psychosis and at 12 months.RESULTS: In FEP, 80% (n = 134) at baseline, and 76% at 12 months follow up, had suboptimal vitamin D levels (<20 ng/ml). Suboptimal levels of 25 (OH) D at …
Primary enduring negative symptoms in schizophrenia and major depression.
1995
Abstract Primary enduring negative symptoms (PENS) were studied in 26 patients with DSM-III-R schizophrenia and in 94 patients with unipolar major depressive episodes 5 years after the index episode. PENS were assessed with the Schedule for Deficit Syndrome (SDS). Negative symptoms were also assessed with the Scale for Assessment of Negative Symptoms (SANS) and subclassified into primary and secondary according to the SDS. The frequency of PENS did not differ significantly between schizophrenics and non-schizophrenic patients. Enduring negative symptoms (regardless of whether primary or not) were more frequently observed in schizophrenia (65% according to the SDS, and 88% according to the S…
Outcome of suicidal patients with schizophrenia: results from a naturalistic study.
2010
Schennach-Wolff R, Jager M, Seemuller F, Obermeier M, Schmauss M, Laux G, Pfeiffer H, Naber D, Schmidt LG, Gaebel W, Klosterkotter J, Heuser I, Maier W, Lemke MR, Ruther E, Klingberg S, Gastpar M, Moller H-J, Riedel M. Outcome of suicidal patients with schizophrenia: results from a naturalistic study. Objective: Purpose was to assess suicidality before and at the time of admission in patients with schizophrenia and compare outcome differences. Method: Biweekly PANSS (Positive and Negative Syndrome Scale), HAMD (Hamilton Depression Rating Scale) and UKU (Udvalg for Klinske Undersogelser Side Effect Rating Scale) ratings were evaluated in 339 in-patients with schizophrenic spectrum disorder…
Ultrasonic Echo Intensity as a New Noninvasive In Vivo Biomarker of Frailty
2017
Objectives To investigate whether muscle quality based on echo intensity (EI) is associated with muscle strength (MS) and correlates with risk of frailty in elderly outpatients. Design Cross-sectional, experimental study. Setting Outpatient clinic. Participants Individuals aged 20 to 90 (N = 112). Individuals aged 20 to 59 participated as controls. Those aged 60 and older participated in the experimental group and were subdivided into robust, prefrail, and frail according to the Fried frailty criteria. Measurements EI, muscle thickness (MT), and subcutaneous fat thickness (SFT) of the anterior compartment of the thigh were measured using ultrasound images. MS was quantified using a hand dyn…
The mechanical efficiency of locomotion in men and women with special emphasis on stretch-shortening cycle exercises.
1986
The mechanical efficiency of the leg extensor musculature of men and women was examined with a special "sledge ergometer". The subjects (ten males and ten females) performed pure positive work, pure negative work and a combination of negative and positive work (stretch-shortening cycle). The mechanical efficiency of pure positive work was on average 19.8 +/- 1.2% for female subjects and 17.4 +/- 1.2% for male subjects (t = 4.12, P less than 0.001), although the work intensity was equal in both groups. The mechanical efficiency of pure negative work was slightly lower in women than in men (59.3 +/- 14.4% vs 75.6 +/- 29.3%). The mechanical efficiency of positive work (eta +) in a stretch-shor…
A telemedicine platform to improve clinical parameters in paranoid schizophrenia patients: Results of a one-year randomized study
2018
Objective The study objective was to test a smartphone-based MONEO platform designed to improve the clinical condition of paranoid schizophrenia patients. Telemedicine treatment is considered to be as effective as traditional treatment in outpatient clinics. Method A total of 290 patients with paranoid schizophrenia in the symptomatic remission state were recruited to this 12-month multicenter, open-label randomized trial. A study group (n = 191) received a smartphone with the MONEO platform installed. Patients conducted cognitive training twice a week. Patients' mental state was assessed every month via teleconference. A placebo group (n = 99) received a platform with functionality limited…
Time course of antipsychotic treatment response in schizophrenia: Results from a naturalistic study in 280 patients
2010
To describe the course of positive and negative symptoms during inpatient treatment and examine remission and response rates under routine clinical care conditions.Two hundred and eighty inpatients with schizophrenia (DSM-IV criteria) were assessed with the Positive and Negative Syndrome Scale (PANSS) at admission and at biweekly intervals until discharge from hospital. Remission was defined according to the symptom-severity component of the consensus criteria (Remission in Schizophrenia Working Group) as a rating of three or less in the relevant PANSS items at discharge, and response as a reduction of at least 20% in the PANSS total score from admission to discharge.The mean duration of in…
The time course of temporal discrimination: An ERP study
2009
Objective: The question of how temporal information is processed by the brain is still a matter of debate. This study aimed to elucidate the brain electrical activity associated with a visual temporal discrimination task. Methods: For this purpose, 44 participants were required to compare pairs of sequentially presented time intervals: a fixed standard interval (1000 ms), and an equal-to-standard, longer (1200 ms) or shorter (800 ms) comparison interval. Behavioural data and event-related potentials (ERPs) were analyzed. Results: Long intervals were more rapidly identified than short intervals. The amplitude of the contingent negative variation (CNV) found at frontocentral sites before the …
Event-related potentials reveal rapid registration of features of infrequent changes during change blindness.
2009
Abstract Background Change blindness refers to a failure to detect changes between consecutively presented images separated by, for example, a brief blank screen. As an explanation of change blindness, it has been suggested that our representations of the environment are sparse outside focal attention and even that changed features may not be represented at all. In order to find electrophysiological evidence of neural representations of changed features during change blindness, we recorded event-related potentials (ERPs) in adults in an oddball variant of the change blindness flicker paradigm. Methods ERPs were recorded when subjects performed a change detection task in which the modified i…