Search results for "Neonato"
showing 10 items of 97 documents
Efectividad de las medidas y estrategias de prevención de úlceras por presión en neonatos
2020
espanolRESUMEN Objetivos: Analizar la efectividad, en terminos de disminucion de la incidencia de ulceras por presion (UPP), de las medidas y estrategias preventivas de UPP en neonatos hospitalizados. Metodo: La recuperacion de estudios se realizo a traves de tres bases de datos (Medline a traves de PubMed, Scopus y Science Direct) y a partir de un experto. Solamente se incluyeron en esta revision los estudios publicados del 2007 al 2017 en espanol o ingles, que de forma directa o indirecta valoraran la efectividad de una medida o estrategia preventiva de UPP en neonatos hospitalizados y que en cuanto al diseno fueran o estudios clinicos controlados o cuasiexperimentales. Resultados: De 100…
The Lasting Influences of Early Food-Related Variety Experience: A Longitudinal Study of Vegetable Acceptance from 5 Months to 6 Years in Two Populat…
2016
International audience; Children's vegetable consumption falls below current recommendations, highlighting the need to identify strategies that can successfully promote better acceptance of vegetables. Recently, experimental studies have reported promising interventions that increase acceptance of vegetables. The first, offering infants a high variety of vegetables at weaning, increased acceptance of new foods, including vegetables. The second, offering an initially disliked vegetable at 8 subsequent meals markedly increased acceptance for that vegetable. So far, these effects have been shown to persist for at least several weeks. We now present follow-up data at 15 months, 3 and 6 years ob…
Clinicians in 25 countries prefer to use lower levels of oxygen to resuscitate preterm infants at birth.
2016
Aim This study determined current international clinical practice and opinions regarding initial fractional inspired oxygen (FiO2) and pulse oximetry (SpO2) targets for delivery room resuscitation of preterm infants of less than 29 weeks of gestation. Methods An online survey was disseminated to neonatal clinicians via established professional clinical networks using a web-based survey programme between March 9 and June 30, 2015. Results Of the 630 responses from 25 countries, 60% were from neonatologists. The majority (77%) would target SpO2 between the 10th to 50th percentiles values for full-term infants. The median starting FiO2 was 0.3, with Japan using the highest (0.4) and the UK usi…
Resuscitation with room air instead of 100% oxygen prevents oxidative stress in moderately asphyxiated term neonates.
2001
Background. Traditionally, asphyxiated newborn infants have been ventilated using 100% oxygen. However, a recent multinational trial has shown that the use of room air was just as efficient as pure oxygen in securing the survival of severely asphyxiated newborn infants. Oxidative stress markers in moderately asphyxiated term newborn infants resuscitated with either 100% oxygen or room air have been studied for the first time in this work. Methods. Eligible term neonates with perinatal asphyxia were randomly resuscitated with either room air or 100% oxygen. The clinical parameters recorded were those of the Apgar score at 1, 5, and 10 minutes, the time of onset of the first cry, and the tim…
Oxidative stress in asphyxiated term infants resuscitated with 100% oxygen
2003
Although room air is adequate for resuscitating asphyxiated newborn infants, guidelines recommend using 100% oxygen. Hyperoxemia, as has been noted in animal studies, could cause delayed breathing, increased oxygen consumption, and disordered cerebral circulation. In addition, 100% oxygen has caused prolonged oxidation of blood glutathione in neonates. In this study, 51 asphyxiated neonates born at term were randomly assigned to resuscitation with room air (RAR) and 55 to resuscitation with 100% oxygen (OxR). The goal was to learn whether using oxygen for resuscitation triggers oxidative stress. Critical criteria were the Apgar score, the time of the first cry, and sustained respiration. Si…
Metabolomic Analysis of the Effect of Postnatal Hypoxia on the Retina in a Newly Born Piglet Model
2013
The availability of reliable biomarkers of brain injury secondary to birth asphyxia could substantially improve clinical grading, therapeutic intervention strategies, and prognosis. In this study, changes in the metabolome of retinal tissue caused by profound hypoxia in an established neonatal piglet model were investigated using an ultra performance liquid chromatography - quadrupole time of flight mass spectrometry (UPLC-QTOFMS) untargeted metabolomic approach, which included Partial Least Squares - Discriminant Analysis (PLSDA) multivariate data analysis. The initial identification of a set of discriminant metabolites from UPLC-QTOFMS data was confirmed by target UPLC-MS/MS and allowed t…
Consequences of neonatal resuscitation with supplemental oxygen.
2008
There has been considerable controversy surrounding the optimal inspired oxygen concentration for resuscitation of term and preterm infants. We have developed a rat pup model to quantify both physiologic and biochemical parameters associated with normoxic vs. hyperoxic resuscitation. We have confirmed existing human data that hyperoxic resuscitation of rat pups is associated with a significant delay in onset of spontaneous respiratory efforts. Both 40% and 100% inspired oxygen delayed onset of respiratory activity when compared to 21% oxygen. We have also documented, in the rat pup model, that hyperoxic resuscitation is associated with reduced levels of glutathione at 24 hours post resuscit…
Novel analytical approaches for biomarker detection in neonatology
2021
La principal motivación de esta tesis doctoral es el análisis de biomarcadores basados en moléculas pequeñas de relevancia en el periodo neonatal, específicamente, en situaciones de asfixia perinatal y estrés oxidativo. Se han desarrollado métodos analíticos novedosos y se han adaptado para lidiar con los retos que suponen las muestras en neonatología, empleando enfoques mínimamente invasivos y pequeñas cantidades de muestra. Se han implementado diferentes procesados de muestra para el análisis de orina, sangre y leche humana como la extracción en fase sólida y diferentes tipos de desprotenización. Los métodos analíticos desarrollados están basados en: cromatografía líquida acoplada a espec…
LA SINDROME DA IPOPERISTALTISMO NEL NEONATO. A proposito di un caso clinico associato a malrotazione, intestino corto, malassorbimento
1988
Viene descritto un caso di una Sindrome caratterizzata da ipopèeristaltismo, intestino corto, malassorbimento