Search results for "Neri"

Noninvasive ventilation for acute hypoxemic respiratory failure/ARDS: The show must go on

2018

Groupthink and Project Performance: The Influence of Personal Traits and Interpersonal Ties

2015

Contains fulltext : 166103.pdf (Publisher’s version ) (Closed access) This study explores whether the negative impact of “groupthink concurrence-seeking behavior” (GTB) on business process reengineering (BPR) projects is affected by group members personal traits and interpersonal ties within the group. To this purpose we conduct and present the results of a longitudinal controlled field experiment over 18 BPR projects lasting 3 months and involving 18 teams comprising 71 first-year MBA students. The main contribution of this study is twofold. First, we explicitly consider and measure the core construct of groupthink phenomenon: that is, GTB. Existing organizational behavior literature has, …

System Dynamics in the Predictive Analytics of Container Freight Rates

2021

This study proposes a two-tier cross-validation and backtesting procedure, including expanding and rolling-window test metrics in predictive analytics of container freight rates by utilizing the system dynamics approach. The study utilized system dynamics to represent the nonlinear complex structure of container freight rates for predictive analytics and performed univariate and multivariate time-series analysis as benchmarks of the conventional approach. In particular, the China containerized freight index (CCFI) has been investigated through various parametric methodologies (both conventional time-series and system dynamics approaches). This study follows a strict validation process cons…

Acquisition of Generic Competencies Through Project Simulation in Translation Studies

2017

Motivated by the research in several international and interdisciplinary initiatives, for example, P21 Partnership for 21st Century Learning or the Collegiate Learning Assessment instruments, we seek for a scalable and measureable set of generic competencies for translation studies. Up to now, the acquisition of competencies in translation studies has primarily been operationalized by implementing authentic projects in higher education classes using socio-constructivist approaches. This results in a hybridization of subject-specific competencies and generic competencies in translator education. Because of the necessity to focus on the acquisition of generic competencies as a primary learnin…

2D size, position and shape definition of defects by B-scan image analysis

2015

The non-destructive evaluation of defects by automatic procedures is of great importance for structural components. Thanks to the developments of the non-contact ultrasonic techniques, the automation of the inspections is gaining a progressively important role. In this work, an automatic inspection technique for the evaluation of defects by the analysis of B-scan images obtained by a laser ultrasonic system is presented. The data are extracted directly from a B-scan map obtained for a panel with internal defects, and are used to build an image of the cross section of the panel. The proposed automatic procedure allows the definition of size, position and shape of defects in panels of known t…

A 3D‑scaffold of PLLA induces the morphological differentiation and migration of primary astrocytes and promotes the production of extracellular vesi…

2019

The present study analyzed the ability of primary rat astrocytes to colonize a porous scaffold, mimicking the reticular structure of the brain parenchyma extracellular matrix, as well as their ability to grow, survive and differentiate on the scaffold. Scaffolds were prepared using poly-L-lactic acid (PLLA) via thermally-induced phase separation. Firstly, the present study studied the effects of scaffold morphology on the growth of astrocytes, evaluating their capability to colonize. Specifically, two different morphologies were tested, which were obtained by changing the polymer concentration in the starting solution. The structures were characterized by scanning electron microscopy, and a…

3D cultures of primary astrocytes on Poly-L-lactic acid scaffolds

Tissue engineering is an emerging multidisciplinary field that aims at reproducing in vitro tissues with morphological and functional features similar to the biological tissue of the human body. Polymeric materials can be used in contact with biological systems in replacing destroyed tissue by transplantation [1]. Several biopolymers, including poly L (lactic acid) (PLLA), have been used in biomedical applications to set scaffolds with ductile proprieties and biodegradation kinetics [2]. In particular, the PLLA scaffold topography mimics the natural extracellular matrix and makes it a good candidate for neural tissue engineering. We report about of 3D system the PLLA porous scaffolds prepar…

Development of a novel in vitro system for biomedical applications

2022

Nella ricerca scientifica e medica, l'uso degli animali ha apportato notevoli benefici all’uomo. Sebbene la loro fisiologia non imiti perfettamente il corpo umano, essi agiscono come perfetti "modelli" per lo studio delle malattie umane e lo sviluppo di nuovi farmaci e trattamenti. Tuttavia, secondo la Food and Drug Administration (FDA), solo l'8% dei farmaci testati sugli animali è considerato sicuro ed efficace per l'uso sull’essere umano, il 92% non lo è. Questi tassi di fallimento estremamente elevati nello sviluppo di farmaci, insieme ai costi in forte aumento, hanno portato molti ricercatori a rivalutare il valore degli studi in vivo sugli animali. Questo è stato il motivo per cui, ne…

PLLA scaffolds with controlled architecture as potential microenvironment for in vitro tumor model

2019

Abstract The "microenvironment" where a tumor develops plays a fundamental role in determining its progression, the onset of metastasis and, eventually, its resistance to therapies. Tumor cells can be considered more or less invasive depending both on the nature of the cells and on the site where they are located. Commonly adopted laboratory culture protocols for the investigation of tumor cells take usually place on standard two-dimensional supports. However, such cultures do not allow for reproduction of the biophysical properties of the tumor’s microenvironment, thus causing the cells to lose most of their relevant characteristics. In this work MDA-MB 231 breast cancer cells were cultiva…

Análisis de la función de los espacios culturales en la redefinición de las políticas culturales de las ciudades. Un estudio de los casos de las área…

2021

Esta tesis aborda la relación entre los espacios culturales y las políticas culturales, específicamente en el ámbito urbano. Concretamente, en este proyecto de investigación argumentamos, en primer lugar, que las políticas culturales urbanas y las políticas de creación de espacios culturales están regidas por una misma lógica se articulan en un todo funcional al paradigma dominante de política cultural (en la que los espacios culturales son a la vez derivada y condición del modelo de democratización cultural). En segundo lugar, sostenemos que los espacios culturales son la clave de bóveda de las políticas de democratización cultural, en tanto que constituyen la herramienta principal de su m…