Search results for "Neurologi"

Filosofia e psicologia nel giovane De Sarlo (1887-1893)

2008

Il presente contributo è rivolto all’approfondimento dei primi anni dell’attività e della produzione di Francesco De Sarlo, a partire dall’anno della sua laurea in medicina nell’Ateneo napoletano, avvenuta nel 1887. Dopo avere esercitato la professione medica per alcuni anni, il giovane De Sarlo si è dedicato alla psichiatria e alla neurologia. A partire dal 1892/1893 ha insegnato filosofia nei licei, seppure aspirando a quello universitario; infatti, nel 1897 ha conseguito la libera docenza in Filosofia teoretica e tre anni dopo ha ottenuto il suo primo insegnamento nell’Istituto di Studi Superiori di Firenze. Si è prestata attenzione anche ai primi studi di De Sarlo, relativi agli anni 18…

Linear inverse filtering improves spatial separation of nonlinear brain dynamics: a simulation study.

2000

We examined topographic variations in nonlinear measures based on scalp voltages, which were generated by two simulated current dipoles each placed in a different hemisphere of a spherical volume conductor (three-shell model). Dipole dynamics were that of a three-torus and the x-component of the Lorenz-system and scalp voltage were calculated for a configuration of 29 electrode positions. Although estimates for correlation dimension D2 and Lyapunov exponent L1 were close to the theoretical values for the original time series, the simulated scalp voltage data showed almost no topographic resolution of dipole positions. In order to enhance topographic differentiation, we constructed linear in…

Small-signal analysis of the encoder mechanism in the lobster stretch receptor and the frog and cat muscle spindle.

1975

Ausgehend von der Leitwert-Potential-Beziehung als Bedingung fur die Impulsauslosung an erregbaren Membranen (Chaplain, 1974) wird eine Kleinsignal-Analyse des Kodierungsvorganges in Mechanorezeptoren beschrieben. Hierbei wird die Theorie der Systeme mit zeitvariablen Parametern angewendet. Das beschriebene mathematische Modell erlaubt quantitative Aussagen fur den Frequenzgang unabhangig davon ob die Momentafrequenz oder die Impulsdichte als Ausgangssignal betrachtet wird. Die Approximation experimenteller Daten gelingt sowohl fur die Ansteuerung des Kodierers bei intrazellularer Stromstimulierung im Fall des Dehnungsrezeptors wie auch durch Leitwertanderungen als Folge des mechano-elektri…

Clinical and Instrumental Findings and Disability Progression in Primary Progressive and Progressive Relapsing Multiple Sclerosis: A Comparison Study…

2013

Primary progressive crossed aphasia in dextrals: report of three cases

2013

Linkage analysis and disease models in benign familial infantile seizures: a study of 16 families.

2006

Summary: Purpose: Benign familial infantile seizures (BFIS) is a genetically heterogeneous condition characterized by partial seizures, onset age from 3 to 9 months, and favorable outcome. BFIS loci were identified on chromosomes 19q12-13.1 and 16p12-q12, allelic to infantile convulsions and choreathetosis. The identification of SCN2A mutations in families with only infantile seizures indicated that BFNIS and BFIS may show overlapping clinical features. Infantile seizures also were in a family with familial hemiplegic migraine and mutations in the ATP1A2 gene. We have examined the heterogeneous genetics of BFIS by means of linkage analysis. Methods: Sixteen families were examined. Probands …

A high-throughput chemical screen in DJ-1β mutant flies identifies zaprinast as a potential Parkinson's disease treatment

2021

AbstractDopamine replacement represents the standard therapy for Parkinson’s disease (PD), a common, chronic, and incurable neurological disorder; however, this approach only treats the symptoms of this devastating disease. In the search for novel disease-modifying therapies that target other relevant molecular and cellular mechanisms, Drosophila has emerged as a valuable tool to study neurodegenerative diseases due to the presence of a complex central nervous system, the blood–brain barrier, and a similar neurotransmitter profile to humans. Human PD-related genes also display conservation in flies; DJ-1β is the fly ortholog of DJ-1, a gene for which mutations prompt early-onset recessive P…

Toxic effects on astrocytes of extracellular vesicles from CSF of multiple sclerosis patients: a pilot in vitro study.

2020

Multiple sclerosis (MS) is an autoimmune and degenerative disorder of the central nervous system (CNS) that causes a progressive loss of motor and cognitive perfor-mances. Moreover, since the earlier phases, axonal loss as well as neuronal degener-ation and a failure of oligodendrocytes to promote myelin repair have been demon-strated. In previous studies, it has been shown that the treatment of rat neuronal primary cultures with serum from MS patients can be toxic for neurons. Here we report a pilot investigation showing that CSF from patients contains extracellular vesicles (EVs) able to induce cell death in rat cultured astrocytes. Although these data are still preliminary, they suggest …

Intravenous gammaglobulin treatment in chronic progressive multiple sclerosis

1998

Perturbed interactions of mutant proteolipid protein/DM20 with cholesterol and lipid rafts in oligodendroglia: implications for dysmyelination in spa…

2006

Missense mutations in the humanPLP1gene lead to dysmyelinating diseases with a broad range of clinical severity, ranging from severe Pelizaeus–Merzbacher disease (PMD) to milder spastic paraplegia type 2 (SPG-2). The molecular pathology has been generally attributed to endoplasmic reticulum (ER) retention of misfolded proteolipid protein (PLP) (and its splice isoform DM20) and induction of the unfolded protein response. As opposed to previous studies of heterologous expression systems, we have analyzed PLP/DM20 trafficking in oligodendroglial cells, thereby revealing differences between PMD and SPG-2-associated PLP/DM20 isoforms. PLPA242Vand DM20A242V(jimpy-msdin mice), associated with seve…