Search results for "Neurologi"

showing 10 items of 1189 documents

Implications for Estrogens in Parkinson’s Disease

2006

Evidence from experimental and epidemiological studies suggests a role of sex hormones in the pathogenic process leading to neurodegenerative diseases, (i.e., Alzheimer's and Parkinson's disease). The effects of sexual steroid hormones are complex and vary with the events of women's fertile life. Estrogens are supposed to influence dopamine synthesis, metabolism, and transport; however, there is no consensus regarding the direction, locus, and mechanism of the effect of estrogens on the dopaminergic system. A neuroprotective effect of estrogens has been demonstrated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-animal models of Parkinson's disease (PD). Epidemiological studies indi…

Settore MED/26 - NeurologiaAge at menopause Parkinson's disease

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Tumor diagnosis preceding Alzheimer’s disease: a case-control study

2011

Settore MED/26 - NeurologiaAlzheimer's disease tumor cancer

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Percutaneous endoscopic gastrostomy in amyotrophic lateral sclerosis

2011

Background: Percutaneous endoscopic gastrostomy (PEG) is offered to amyotrophic lateral sclerosis (ALS) patients with severe dysphagia. Immediate benefits of PEG are adequate food intake and weight stabilization. However, the impact of PEG on survival is still uncertain. In this work we retrospectively evaluated the effect of PEG on survival in a cohort of ALS patients followed in a tertiary referral centre. Methods: Between 2000 and 2007, 150 dysphagic ALS patients were followed until death or tracheostomy. PEG was placed in 76 patients who accepted the procedure and survival was analysed using the Kaplan-Meier life-table method. Results: In ALS patients submitted to PEG, no major complica…

Settore MED/26 - NeurologiaAmyotrophic lateral sclerosis dysphagia PEG respiratory impairment survival

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