Search results for "Neurologi"

ANODAL TRANSCRANIAL DIRECT CURRENT STIMULATION (TDCS) APPLIED TO THE MOTOR CORTEX AMELIORATES FREEZING OF GAIT IN PATIENTS AFFECTED BY PARKINSON’S DI…

2012

Background: Progression of Parkinson’s disease (PD) is frequently characterized by the occurrence of freezing of gait (FOG), which generally does not improve with dopaminergic therapy and with current available surgical therapies. Recent evidences show that motor symptoms may be ameliorated by means of non-invasive brain stimulation techiniques in PD (transcranial current direct stimulation, TDCS; repetitive transcranial magnetic stimulation, RTMS). Objective: To investigate the efficacy of anodal TDCS in the treatment of FOG in PD. Excitatory anodal tDCS was applied unilaterally to the motor and premotor cortices controlateral to the most affected leg. Methods: randomized, double-blind, sh…

Reversible posterior leukoencephalopathy syndrome in a patient with thrombotic thrombocytopenic purpura

2008

Whole-brain histogram and voxel-based analyses of apparent diffusion coefficient and magnetization transfer ratio in celiac disease, epilepsy, and ce…

2007

BACKGROUND AND PURPOSE: Diffusion and magnetization transfer (MT) techniques have been applied to the investigation with MR of epilepsy and have revealed changes in patients with or without abnormalities on MR imaging. We hypothesized that also in the coeliac disease (CD), epilepsy and cerebral calcifications (CEC) syndrome diffusion and MT techniques could reveal brain abnormalities undetected by MR imaging and tentatively correlated to epilepsy. MATERIALS AND METHODS: Diffusion and MT weighted images were obtained in 10 patients with CEC, 8 patients with CD without epilepsy and 17 healthy volunteers. The whole brain apparent diffusion coefficient (ADC) and MT ratio (MTR) maps were analyze…

I disturbi Urinari in corso di Malattia di Parkinson

Metabolic Syndrome as putative independent associated/risk factor for Alzheimer’Disease and Mild Cognitive Impairment

2014

Metabolic syndrome (MetS) is a cluster of vascular risk factors [1] that is well established to increase the risk of diabetes, cardiovascular disease, and stroke [2, 3]. MetS also appears to increase the risk of age-associated cognitive decline, overall dementia, and vascular dementia (VaD) in particular [4], but the role of MetS in Alzheimer’s disease (AD) remains inconclusive from the contrasting findings reported so far [5–11]. Amnestic Mild Cognitive Impairment (aMCI) is presumably a pathological-based prodromal stage of AD with an annual rate of conversion to dementia of 5 to 10% in community-based populations [12] and 10 to 15% among those in specialty clinics [13]. Only a few studies…

Heart involvement in patients treated with mitoxantrone for multiple sclerosis

2010

Return of disease activity after natalizumab therapy discontinuation in patients with multiple sclerosis: frequency and clinical and instrumental pre…

2012

Clinical effects of different montages of Transcranial Direct Current Stimulation (tDCS) in patients with Parkinson’s Disease

2016

Background: Parkinson’s disease (PD) is characterized by motor deficits which may not completely respond to the dopaminergic therapy, thus posing a therapeutic challenge. Non-invasive brain stimulation techniques such as transcranial direct current stimulation (tDCS) have shown promising results as possible alternative of treatment in different neurological disorders including PD. The therapeutic effect of tDCS, which may increase (anodal currents) or decrease (cathodal currents) the cortical excitability level, likely relies on modulation of cortico-subcortical interactions and abnormal patterns of cortical activation. Objective: To investigate safety and therapeutic potential of different…

Long-term survival of Parkinson’s disease: a population-based case-control study.

2006

In a set of a population-based study, long-term survival of 59 prevalent PD patients was compared with that of individuals free of neurological diseases matched 1:2 by sex and age of enrolment. PD individuals, compared with reference subjects, showed a two-fold increased risk of death (OR 2.1; 95 % CI 1.4, 3.1). Among causes of death, pneumonia and cachexia were significantly more frequent among PD patients than among individuals free of neurological diseases. We confirmed in a long-term follow-up study an increased mortality among PD individuals compared with that of the general population.

Clinical features, disease course and prognosis in patients with paediatric and young adult onset multiple sclerosis

2013

Background. Multiple sclerosis (MS) patients develop their first symptoms before adolescence approximately in 5%. Studies comparing clinical and prognostic characteristics in early onset MS, did not show homogeneous results. Objective. Aim of this study was to investigate characteristics of early onset MS patients and compare them with patients who experienced MS onset later. Methods. MS patients diagnosed as affected by MS according to Poser's criteria, were included if they experienced symptoms onset before age 25. They were classified in three groups. Group A: patients who had their onset until they were 16 years old Group B: individuals with onset between 17 and 20 yearsGroup C: patient…