Search results for "Neuron"

Mental fatigue induced by prolonged self-regulation does not exacerbate central fatigue during subsequent whole-body endurance exercise

2015

International audience; It has been shown that the mental fatigue induced by prolonged self-regulation increases perception of effort and reduces performance during subsequent endurance exercise. However, the physiological mechanisms underlying these negative effects of mental fatigue are unclear. The primary aim of this study was to test the hypothesis that mental fatigue exacerbates central fatigue induced by whole-body endurance exercise. Twelve subjects performed 30 min of either an incongruent Stroop task to induce a condition of mental fatigue or a congruent Stroop task (control condition) in a random and counterbalanced order. Both cognitive tasks (CTs) were followed by a whole-body …

3D Printing Neuron Equivalent Circuits: An Undergraduate Laboratory Exercise.

2018

The electrical equivalent circuit for a neuron is composed of common electrical components in a configuration that replicates the passive electrical properties and behaviors of the neural membrane. It is a powerful tool used to derive such fundamental neurophysiological equations as the Hodgkin-Huxley equations, and it is also the basis for well-known exercises that help students to model the passive (Ohmic) properties of the neuronal membrane. Unfortunately, as these exercises require basic knowledge of electronics, they are generally not physically conducted in biomedical courses, but remain merely conceptual exercises in a book or simulations on a computer. In such manifestations, they l…

NeuronAlg: An Innovative Neuronal Computational Model for Immunofluorescence Image Segmentation

2023

Background: Image analysis applications in digital pathology include various methods for segmenting regions of interest. Their identification is one of the most complex steps and therefore of great interest for the study of robust methods that do not necessarily rely on a machine learning (ML) approach. Method: A fully automatic and optimized segmentation process for different datasets is a prerequisite for classifying and diagnosing indirect immunofluorescence (IIF) raw data. This study describes a deterministic computational neuroscience approach for identifying cells and nuclei. It is very different from the conventional neural network approaches but has an equivalent quantitative and qu…

Characterization of neuronal neroid lipofuscinosis phenotype in three different cell lines subjected to RNA interference

2008

The Major Heat Shock Proteins, Hsp70 and Hsp90, in 2-Methoxyestradiol-Mediated Osteosarcoma Cell Death Model

2020

2-Methoxyestradiol is one of the natural 17&beta

Il trattamento con RSV e l’espressione transgenica di PGC-1α proteggono i neuroni dopaminergici nel modello MPTP murino del morbo di Parkinson. Resve…

2012

NEURONS AND ASTROCYTES SHED EXTRACELLULAR VESICLES THAT SEEM TO VEHICLE ANGIOGENIC FACTORS

2007

Nicotinic receptor agonists as neuroprotective/neurotrophic drugs. Progress in molecular mechanisms

2007

In the present work we reviewed recent advances concerning neuroprotective/neurotrophic effects of acute or chronic nicotine exposure, and the signalling pathways mediating these effects, including mechanisms implicated in nicotine addiction and nAChR desensitization. Experimental and clinical data largely indicate long-lasting effects of nicotine and nicotinic agonists that imply a neuroprotective/neurotrophic role of nAChR activation, involving mainly alpha 7 and alpha 4 beta 2 nAChR subtypes, as evidenced using selective nAChR agonists. Compounds interacting with neuronal nAChRs have the potential to be neuroprotective and treatment with nAChR agonists elicits long-lasting neurotrophic e…

Inteligencji wieki stare i nowe [Rec. David Adam: Ukryty geniusz. Pigułki na rozum, hakerzy mózgu i sekrety inteligencji. Kraków 2020]

2020

Książka Ukryty geniusz. Pigułki na rozum, hakerzy mózgu i sekrety inteligencji Davida Adama to pozycja wpisująca się w trend wydawniczy do publikowania książek przez znanych i cenionych historyków i popularyzatorów nauki, jak np. Niall Ferguson, Youval Noah Harari czy Bill Bryson. Autor, z wykształcenia chemik, zabiera czytelnika w podróż po historii badań ludzkiej inteligencji. W książce sporo miejsca poświęcono także serii eksperymentów, którym — na potrzeby publikacji — autor sam się poddał. Wnioski, jakie wyciągnął zarówno z przeszłości, jak i teraźniejszości, skłoniły go do stwierdzenia, że przyszłość należy do rewolucji neuronaukowej.

Red Light Optogenetics in Neuroscience

2022

Optogenetics, a field concentrating on controlling cellular functions by means of light-activated proteins, has shown tremendous potential in neuroscience. It possesses superior spatiotemporal resolution compared to the surgical, electrical, and pharmacological methods traditionally used in studying brain function. A multitude of optogenetic tools for neuroscience have been created that, for example, enable the control of action potential generation via light-activated ion channels. Other optogenetic proteins have been used in the brain, for example, to control long-term potentiation or to ablate specific subtypes of neurons. In in vivo applications, however, the majority of optogenetic too…