Search results for "Neuropathology"
showing 3 items of 43 documents
Caspase-3 contributes to ZO-1 and Cl-5 tight-junction disruption in rapid anoxic neurovascular unit damage.
2011
BACKGROUND: Tight-junction (TJ) protein degradation is a decisive step in hypoxic blood-brain barrier (BBB) breakdown in stroke. In this study we elucidated the impact of acute cerebral ischemia on TJ protein arrangement and the role of the apoptotic effector protease caspase-3 in this context. METHODOLOGY/PRINCIPAL FINDINGS: We used an in vitro model of the neurovascular unit and the guinea pig whole brain preparation to analyze with immunohistochemical methods the BBB properties and neurovascular integrity. In both methodological approaches we observed rapid TJ protein disruptions after 30 min of oxygen and glucose deprivation or middle cerebral artery occlusion, which were accompanied by…
Safety and diagnostic accuracy of neuroendoscopic biopsies: an international multicenter study
2013
Object Analysis of the safety and morbidity of neuroendoscopic biopsies (NEBs), as well as the reliability in obtaining an accurate diagnosis, has until now been based on studies with relatively small sample sizes. Through the cooperative efforts of several international medical centers, authors of the present study collected data on a large number of patients to obtain better insight into this issue. When possible, they compared pathology obtained through an NEB with the “gold-standard” pathology obtained in open surgery. Methods Thirteen randomly chosen medical centers in 9 countries collected data for patients who had undergone NEB, which were then analyzed for universal complications, …
Neuropathology of Cerebellar Infarction: Its Morphology in Comparison to Selective Postmortem Angiography of Cerebellar Arteries
1994
A typology of infarctions [11, 20] is established for the cerebral hemispheres and has recently also been used, chiefly in neuroradiological diagnosis, for cerebellar infarctions [2–5, 8, 10, 16]. Detailed clinical [12] and microangiographic [7, 9, 13, 15, 17] investigations of the vascularization of the posterior cranial fossa can be referred to in this context. With the aid of selective postmortem angiograms we examined the territories of the superior cerebellar artery (SCA), anterior inferior cerebellar artery (AICA), and posterior inferior cerebellar artery (PICA) on serial sections in the three planes of projection. The sagittal plane offers decisive advantages for assigning cerebellar…