Search results for "Neutron capture"
showing 6 items of 86 documents
closo-borane conjugated regulatory peptides retain high biological affinity: synthesis of closo-borane conjugated Tyr(3)-octreotate derivatives for B…
2008
Despite the improvements in cancer therapy during the past years, high-grade gliomas and many other types of cancer are still extremely resistant to current forms of therapy. Boron neutron capture therapy (BNCT) provides a promising way to destroy cancer cells without damaging healthy tissue. However, BNCT in practice is still limited due to the lack of boron-containing compounds that selectively deliver boron to cancer cells. Since many neuroendocrine tumors show an overexpression of the somatostatin receptor, it was our aim to synthesize compounds that contain a large number of boron atoms and still show high affinity toward this transmembrane receptor. The synthetic peptide Tyr (3)-octre…
Receptor-mediated uptake of boron-rich neuropeptide y analogues for boron neutron capture therapy.
2014
Peptidic ligands selectively targeting distinct G protein-coupled receptors that are highly expressed in tumor tissue represent a promising approach in drug delivery. Receptor-preferring analogues of neuropeptide Y (NPY) bind and activate the human Y1 receptor subtype (hY1 receptor), which is found in 90% of breast cancer tissue and in all breast-cancer-derived metastases. Herein, novel highly boron-loaded Y1 -receptor-preferring peptide analogues are described as smart shuttle systems for carbaboranes as (10) B-containing moieties. Various positions in the peptide were screened for their susceptibility to carbaborane modification, and the most promising positions were chosen to create a mu…
The Hamburg/ESO R-process Enhanced Star survey (HERES)
2004
We report on a dedicated effort to identify and study metal-poor stars strongly enhanced in r-process elements ([r/Fe] > 1 dex; hereafter r-II stars), the Hamburg/ESO R-process Enhanced Star survey (HERES). Moderate-resolution (~2A) follow-up spectroscopy has been obtained for metal-poor giant candidates selected from the Hamburg/ESO objective-prism survey (HES) as well as the HK survey to identify sharp-lined stars with [Fe/H] < -2.5dex. For several hundred confirmed metal-poor giants brighter than B~16.5mag (most of them from the HES), ``snapshot'' spectra (R~20,000; S/N~30 per pixel) are being obtained with VLT/UVES, with the main aim of finding the 2-3% r-II stars expected to be a…
Beta-decay studies for applied and basic nuclear physics
2020
In this review we will present the results of recent beta-decay studies using the total absorption technique that cover topics of interest for applications, nuclear structure and astrophysics. The decays studied were selected primarily because they have a large impact on the prediction of a) the decay heat in reactors, important for the safety of present and future reactors and b) the reactor electron antineutrino spectrum, of interest for particle/nuclear physics and reactor monitoring. For these studies the total absorption technique was chosen, since it is the only method that allows one to obtain beta decay probabilities free from a systematic error called the Pandemonium effect. The me…
High-Resolution 3-D CZT Drift Strip Detectors for Prompt Gamma Ray and Neutron Detection in BNCT
2021
Spectroscopic imagers based on high-Z and wide-bandgap compound semiconductor detectors are widely proposed for the detection of prompt gamma rays in boron neutron capture therapy (BNCT). BNCT is a therapy based on the neutron capture reaction 10B (n,α)7Li. To perform a real-time monitoring of the spatial distribution of 10B during the treatments, the detection of the prompt gamma rays (478 keV), produced by the 7Li recoil nuclei, can be helpful. In this work, we presented the potentialities of new high-resolution CZT drift strip detectors, recently developed by our group, for BNCT measurements. The detectors, exploiting the analysis of the collected-induced charge pulses from anodes, catho…
High yield neutron generator based on a high-current gasdynamic electron cyclotron resonance ion source
2015
In present paper, an approach for high yield compact D-D neutron generator based on a high current gasdynamic electron cyclotron resonance ion source is suggested. Results on dense pulsed deuteron beam production with current up to 500 mA and current density up to 750 mA/cm2 are demonstrated. Neutron yield from D2O and TiD2 targets was measured in case of its bombardment by pulsed 300 mA Dþ beam with 45 keV energy. Neutron yield density at target surface of 109 s 1 cm2 was detected with a system of two 3 He proportional counters. Estimations based on obtained experimental results show that neutron yield from a high quality TiD2 target bombarded by Dþ beam demonstrated in present work accele…