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La blogosfera política española en las Elecciones Generales 2011. Una comparación entre blogs de candidatos, periodistas y ciudadanos
2015
En: Doxa Comunicación : revista interdisciplinar de estudios de comunicación y ciencias sociales. ISSN 1696-019X n. XXI, 2015, pp 78-112 El presente estudio propone un análisis de la blogosfera política española durante la campaña electoral previa a las Elecciones Generales del 20 de noviembre de 2011, con el fin de identificar los principales temas de discusión que centraron el debate en tres tipos de bitácoras: seis blogs de candidatos políticos de las principales formaciones políticas españolas, cuatro a cargo de periodistas destacados de la esfera pública central y cuatro de ciudadanos anónimos. Se plantea un análisis de contenido fundamentado en 57 categorías temáticas para establecer …
"A 304-year experiment which worked some but not all of the time" : Britain and British identities in three English, Scottish and Welsh newspapers in…
2014
Britannia ja sen eri maat ovat unionin pitkän historian kuluessa kohdanneet lukuisia muutoksia ja haasteita. Viimeaikaisimmat näistä haasteista ovat liittyneet esimerkiksi siihen miten unionia ja sen maita hallitaan: vuonna 1997 unionin valtaa hajautettiin sisäisille paikallishallinnoille, jonka jälkeen muun muassa Wales on saavuttanut laajemmat oikeudet omien lakien säätämiseen ja Skotlanti on syksyllä 2014 äänestämässä mahdollisesta itsenäisyydestä. Tällaiset kehitykset herättävät kysymyksiä siitä, miten unioni nykyään toimii, kuinka vahvasti sen eri maat ovat sidoksissa toisiinsa, ja miltä sen tulevaisuus näyttää. Tämän tutkielman tarkoitus on tarkastella sitä, miten Britanniaa ja britti…
Mnemoniskie paņēmieni drukātajos sludinājumos
2021
Mūsdienās reklāmas tiek lietotas, lai ietekmētu patērētāju lēmumu pieņemšanu, un tajās tiek lietotas dažādas reklāmas metodes. Līdztekus citām metodēm, reklāmās tiek lietoti arī mnemoniskie paņēmieni, kas palīdz labāk atcerēties reklāmas tekstus. Šī darba mērķis ir izpētīt mnemoniskos paņēmienus un analizēt mnemonisko paņēmienu biežumu Lielbritānijas laikrakstos, izmantojot kvalitatīvās un kvantitatīvās pētījumu metodes - diskursa un biežuma analīzi. Kopumā tika analizēti četrpadsmit laikraksti, lai tajos atrastu mnemonisks ierīces. Šī pētījuma rezultāti apstiprina, ka 61 no 247 laikrakstu reklāmām ir mnemoniskie paņēmieni, visos 14 Lielbritānijas laikrakstos katrā laikraksta numurā ir vism…
In the literature: February 2019
2019
Malignant pleural mesothelioma (MPM) is a rare and lethal cancer associated to asbestos exposure. Currently, the pemetrexed and cisplatin combination chemotherapy remains the only approved treatment. In the last 5 years, a growing knowledge on mesothelioma pathobiology has translated into the development of multiple novel therapeutic strategies.1 One of the largest reports of comprehensive genomic profiling of MPM was conducted by Bueno and colleagues. Using RNA-seq data, they identified four distinct molecular subtypes, and through exome analysis, they found that BAP1 , NF2 , TP53 , SETD2 , DDX3X , ULK2 , RYR2 , CFAP45 , SETDB1 and DDX51 were significantly mutated.2 In an article recently …
In the literature: June 2018
2018
Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) are a highly active family of compounds that have changed the scenario in ovarian and human epidermal growth factor receptor 2 (HER2) non-amplified breast cancer management in the recent years. Despite impressive clinical activity, a prolonged treatment with PARPi is frequently associated with acquired resistance to this therapy. The identification of mechanisms and strategies to overcome resistance are crucial. Bromodomain containing 4 (BRD4) is a member of the bromodomain and extraterminal (BET) protein family that facilitates oncogenic transcription. BRD4 is frequently amplified in high-grade serous ovarian cancer (HGSOC) and can be …
In the literature: June 2020.
2020
Immunotherapy based on checkpoint blockade has revolutionised cancer treatment during last years. Whereas this approach fails in a relevant group of patients, the knowledge on tumour microenvironment (TME) opened the possibility to the use of additional therapeutic strategies to potentiate antitumour immunity, including depletion of protumourigenic or immune suppressive and activation of specific immune populations using agonistic antibodies. Nevertheless, due to the complexity of the TME, many of these strategies have been indiscriminately advanced to the clinic without clear mechanistic hypotheses. Nowadays, single-cell RNA sequencing (scRNA-seq)-based transcriptome analyses identify T ce…
In the literature: December 2019
2020
The introduction of new high-throughput technologies in oncology and the need to apply precision medicine for cancer patients has led to the detection of several molecular alterations. Among them, activating mutations of ERBB2 have been reported in many solid tumours. In the last years, several clinical trials with covalent tyrosine kinase inhibitors (TKIs) for ERBB2 mutant cancers have been conducted, with different results among several cancer types. In the SUMMIT trial, neratinib was most effective in breast cancer patients, with the majority of responders having tumours with L755S, V777L, or L869R ERBB2 mutations.1 In an elegant article published in C ancer C ell by Robichaux et al ,2 d…