Search results for "Niosome"
showing 3 items of 3 documents
Theoretical and experimental evaluation of decypolyglucoside vesicles as potential drug delivery systems
2006
The aim of this work was to ascertain the capability of a commercial mixture of decylpolyglucoside (Orami.x NS10) to form vesicle structures in water, either alone or in association with cholesterol. To this purpose, we compared results obtained from a theoretical model with those acquired from the experimental characterization of different Orami.x NS10/cliolesterol mixtures. The germen vesicular formation theory was used to predict the formation process of vesicular structures. To this purpose, the energy balance involved in the vesicle formation was calculated using critical concentration for vesicle formation (ccf), surface tension and molecular area of decylpolyglucoside. The ccf was me…
Development of novel diolein–niosomes for cutaneous delivery of tretinoin: Influence of formulation and in vitro assessment
2014
Abstract This work describes innovative niosomes, composed of diolein alone or in association with the hydrophilic penetration enhancer Labrasol ® , as carriers for cutaneous drug delivery. The model drug was tretinoin and conventional, and Labrasol ® containing liposomes was used as controls to evaluate the influence of vesicle composition and the role of Labrasol ® on vesicle physico-chemical properties and performance as skin delivery system. Vesicles, prepared by the thin film hydration technique, were characterized in terms of size distribution, morphology, zeta potential, structure, incorporation efficiency, and rheological properties. The influence of carrier composition on tretinoin…
Thermodynamical aspects regarding the formation of self-assembly decylpolyglucoside structures
2005
In this study, we used a generalized form of a recently reported parametrization based on the differential geometry and the thermodynamics of dispersed systems to ascertain the capability of decylpolyglucoside alone or in association with cholesterol to form vesicle structures (niosomes). The theoretical calculation of the energy balance involved in the vesicles formation was carried out using values of the critical concentration of formation (ccf), surface tension and the molar surface area of the non-ionic surfactant. Furthermore, in order to confirm the theoretical results found in this work, we prepared and characterized vesicles made with decylpolyglucoside and cholesterol. The vesicle…