Search results for "Nod"
showing 10 items of 4007 documents
The immunogenicity of human and murine cytomegaloviruses.
2000
Cytomegaloviruses are strictly host-species-specific. During an aeon of co-evolution, virus and host have found an arrangement: the productive and cytopathogenic cycle of viral gene expression is held in check by the host's immune response. As a consequence, cytomegalovirus disease is restricted to the immunocompromised host. The virus has evolved strategies to avoid its elimination and eventually hides itself in a silent state, referred to as 'viral latency'. Redundant molecular mechanisms have been identified by which cytomegaloviruses interfere with antigen presentation pathways to 'evade' immune control. In the annual period covered by this review, the IE1 protein was revisited as an im…
Adoptive Transfer of T-Cell-Receptor Engineered Human T Cells Specifically Reduces Viral Titers in HLA-Transgenic NSG Mice Infected with a Humanized …
2014
Abstract Reactivation of latent human cytomegalovirus (HCMV) infection is a frequent complication in patients after allogeneic hematopoietic stem cell transplantation (HSCT). Preclinical research in murine models as well as clinical phase I/II trials have shown that the adoptive transfer of virus-specific CD8+ T cells is a therapeutic option for preventing HCMV disease. However, the feasibility of HCMV-specific immunotherapy is currently limited in clinical routine due to technical restrictions. It has also limitations, if the donor is HCMV-seronegative or carries only low numbers of HCMV-specific memory T cells. In this situation, grafting non-reactive T cells by virus-antigen specific T-c…
Evaluating Human T-Cell Therapy of Cytomegalovirus Organ Disease in HLA-Transgenic Mice
2015
Reactivation of human cytomegalovirus (HCMV) can cause severe disease in recipients of hematopoietic stem cell transplantation. Although preclinical research in murine models as well as clinical trials have provided 'proof of concept' for infection control by pre-emptive CD8 T-cell immunotherapy, there exists no predictive model to experimentally evaluate parameters that determine antiviral efficacy of human T cells in terms of virus control in functional organs, prevention of organ disease, and host survival benefit. We here introduce a novel mouse model for testing HCMV epitope-specific human T cells. The HCMV UL83/pp65-derived NLV-peptide was presented by transgenic HLA-A2.1 in the conte…
Irreducibility of Hurwitz spaces of coverings with monodromy groups Weyl groups of type W(B_d)
2007
Let Y be a smooth, connected, projective complex curve of genus ≥0. R. Biggers and M. Fried [J. Reine Angew. Math. 335, 87–121 (1982; Zbl 0484.14002), Trans. Am. Math. Soc. 295, No. 1, 59–70 (1986; Zbl 0601.14022)] proved the irreducibility of the Hurwitz spaces which parametrize coverings of ℙ 1 whose monodromy group is a Weyl of type W(D d ). Here we prove the irreducibility of Hurwitz spaces that parametrize coverings of Y with monodromy group a Weyl group of type W(B d ).
On coverings with special points and monodromy group a Weyl group of type B_d
2014
In this paper we study Hurwitz spaces parameterizing coverings with special points and with monodromy group a Weyl group of type Bd. We prove that such spaces are irreducible if k > 3d ? 3. Here, k denotes the number of local monodromies that are reflections relative to long roots.
On the irreducibility of Hurwitz spaces of coverings with an arbitrary number of special points
2013
In this paper we study Hurwitz spaces of coverings of Y with an arbitrary number of special points and with monodromy group a Weyl group of type D_d, where Y is a smooth, complex projective curve. We give conditions for which these spaces are irreducible.
Data from: The cranium of Proviverra typica (Mammalia, Hyaenodonta) and its impact on hyaenodont phylogeny and endocranial evolution
2019
We describe the first endocast reconstruction of a hyaenodont mammal based on X‐ray microtomography. The endocast belongs to the type material of the European hyaenodont Proviverra typica. We performed phylogenetic analysis to contextualize the evolution of endocranial size and complexity in Hyaenodonta. We added several European hyaenodonts and modified several codings of the most recent character–taxon matrix established to question the relationships within Hyaenodonta. Including these new species in a phylogenetic analysis reveals a new clade: Hyaenodontoidea. Comparisons with several previously described endocasts show that there was an increase in complexity in the convolutions of the …
The key role of hydrogen bonding in the nuclearity of three copper(II) complexes with hydrazone-derived ligands and nitrogen donor heterocycles
2011
International audience; Three new Cu(II) complexes of formula [Cu(L1)(pyz)(CH3OH)]ClO4 (1), [Cu(L1)(4,4′-bpy)(ClO4)]·0.5H2O (2) and [{Cu(L2)(ClO4)}2(μ-4,4′-bpy)] (3) have been synthesised by using pyrazine (pyz) and 4,4′-bipyridine (4,4′-bpy) and tridentate O,N,O-donor hydrazone ligands, L1H and L2H, obtained by the condensation of 1,1,1-trifluoro-2,4-pentanedione with salicyloylhydrazide and benzhydrazide, respectively. The ligands and their complexes have been characterized by elemental analyses, FT-IR, and UV–Vis spectroscopies. Single crystal X-ray structure analysis evidences the metal ion in a slightly deformed square pyramidal geometry in all the complexes. However complexes 1 and 2 …
Preliminary Tests On A Miniaturized Hybrid Pv-Pemfc System
2007
A regenerative hybrid PV-PEMFC low power system is a suitable solution to replace batteries and to supply small electric devices placed in remote areas with no grid connection. Such a system was designed and built including a PV array, electrolyzer, PEMFC stack (6We) and hydrogen storage tank. As well known a hybrid PV-PEMFC energy system may represent a reliable solution to the renewable energy storage problem. Hydrogen produced by such a system is a clean fuel, suitable to replace traditional fuels which contain carbon damaging the environment. The paper reports results of a preliminary, non-dynamic experimental analysis performed on the system in order to study the effects of the anode p…
Neutron-Induced Effects on a Self-Refresh DRAM
2022
International audience; The field of radiation effects in electronics research includes unknowns for every new device, node size, and technical development. In this study, static and dynamic test methods were used to define the response of a self-refresh DRAM under neutron irradiation. The neutron-induced effects were investigated and characterised by event cross sections, soft-error rate, and bitmaps evaluations, leading to an identification of permanent and temporary stuck cells, single-bit upsets, and block errors. Block errors were identified in different patterns with dependency in the addressing order, leading to up to two thousand faulty words per event, representing a real threat fr…