Search results for "Nonagenarians"

showing 6 items of 6 documents

Role of prothrombotic polymorphisms in successful or unsuccessful aging.

2011

The study of the genetic profile of centenarians aims to identify the genes and allelic variants which may influence a greater life expectancy and that can be considered as predisposing factors associated to the aging diseases, such as Alzheimer. Centenarians, that represent a cohort of selected survivors, show an hypercoagulability state characterised by striking signs of high coagulation enzyme activity, as directly assessed by the tested higher plasma level of some important factors involved in the haemostasis balance. Anyway, these individuals seem to have a reduced susceptibility to dementia, as well as to cardiovascular events. In this study we analyze the frequencies of Leiden Factor…

GerontologyMaleAging.media_common.quotation_subjectDiseaseBioinformaticsLeiden factor V; Prothrombin; Nonagenarians; Alzheimer disease; Aging.Polymorphism (computer science)Alzheimer DiseasemedicineDementiaHumansNonagenarianAlleleAllelesmedia_commonAgedSettore MED/04 - Patologia GeneralePolymorphism GeneticSuccessful agingbusiness.industryALZHEIMER’S DISEASEagingLongevityFactor Vmedicine.diseaseCase-Control StudiesCohortFemaleProthrombinGeriatrics and GerontologyAlzheimer's diseasebusinessGerontologyLeiden Factor V
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Autoantibody production in aging: effect of cytokine gene polymorphisms in Sicilian ultra-nonagenarians

2012

aging autoantibodies ultra-nonagenariansSettore MED/05 - Patologia Clinica
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Association of Body Mass Index and Waist Circumference With Physical Functioning: The Vitality 90+ Study

2015

BACKGROUND Both obesity and underweight are associated with impaired physical functioning, but related information on the oldest old population is scarce. Our purpose was to examine whether body mass index, waist circumference (WC), and their combination are associated with physical performance and activities of daily living (ADL) disability in 90-year-old women and men. METHODS Data are from the Vitality 90+ Study, which is a population-based study of persons with age ≥90 years living in the area of Tampere, Finland. Altogether 416 women and 153 men, aged 90-91 years, provided data on body mass index, WC, chair stand, and Barthel Index. Comorbidity, physical exercise, smoking history, livi…

GerontologyMaleAgingWaistHealth StatusPopulationOverweightMotor ActivityBody compositionBody Mass IndexThinnessResidence CharacteristicsActivities of Daily LivingMedicineHumanseducationAbdominal obesityFinlandAged 80 and overeducation.field_of_studyExercise ToleranceBody volume indexbusiness.industryta3141Functional statusAbdominal obesityta3142medicine.diseaseObesityCross-Sectional StudiesObesity AbdominalNonagenariansFemaleSelf ReportGeriatrics and Gerontologymedicine.symptomUnderweightWaist Circumferencebusinesshuman activitiesBody mass indexJournals of Gerontology, Series A
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SARS CoV2 infection _The longevity study perspectives

2021

Graphical abstract

MaleAgingssRNA single-stranded RNARFLP restriction fragment length polymorphismHSPs heat shock proteinsReviewPTMs post-translational modificationsSevere Acute Respiratory SyndromeBiochemistryHIV-1 human immunodeficiency virus-1TNF-α tumor necrosis factor-αEC endothelial cells0302 clinical medicineFluAV influenza A virusI insertionMedicineIFN-γ interferon-γDIC disseminated intravascular coagulationPCR Polymerase Chain Reactionmedia_commonAged 80 and overLongevityRBD receptor-binding domainNeurologyLongevity modelMI myocardial infarctionNK natural killerhPIV2 human parainfluenza virus type 2media_common.quotation_subjectResearching genetic basis of resistance and potential pharmacological targetsLongevityDBP diastolic blood pressureNF-Kb nuclear transcription factor kBRANTES regulated upon activation normal T cell expressed and secretedMphi human macrophages03 medical and health sciencesCox 2 cyclooxygenase 2ORF open reading framePT prothrombin timeSettore MED/05 - Patologia ClinicaHumansMolecular BiologyInflammatory genesARDS acute respiratory distress syndromeNO nitric oxideD deletionCpGIs CpG islandsT2DM type 2 diabetes mellitusmedicine.diseaseFDP fibrin degradation products030104 developmental biologySARS CoV2 severe acute respiratory syndrome Coronavirus 2 virusImmunologyBMI body max indexItalian nonagenarians/centenariansRSV respiratory syncytial virusComplication030217 neurology & neurosurgeryMAPK mitogen-activated protein kinaseIP-10 IFN-γ -Inducible Protein 1040301 basic medicineAT1R activity of angiotensin 1 receptorsDCs dentritic cellsSSCP single strand conformation polymorphismACE/DD polymorphism of the angiotensin converting enzymeFGF21 fibroblast growth factor 21TLR4 toll-like receptor 4NAD nicotinamide adenine dinucleotideACE angiotensin-I converting enzymeAT2R activity of angiotensin 2 receptorsCOVID-19 Coronavirus disease 2019Respiratory distressACE2 angiotensin converting enzyme 2MKP-1 mitogen-activated protein kinase phosphatase-1 ()PD protease domainSNP single nucleotide polymorphismEH essential hypertensionTNFR tumor necrosis factor receptorINR international normalized ratio of the prothrombin timePAI-1 plasminogen activator inhibitor-1Ang angiotensinLPS lipopolysaccharideMCP1 monocyte chemoattractant protein-1medicine.symptomaPTT partial thromboplastin timeBiotechnologyDUSP1 dual specificity phosphatase 1Coronavirus disease 2019 (COVID-19)PC prostate cancerRAS renin-angiotensin aldosterone systemCCR5Δ32 genetic variant of chemokine receptorCOVID-19 Researching genetic basis of resistance and potential pharmacological targets Italian nonagenarians/centenarians Longevity modelAsymptomaticSARS-1 severe acute respiratory syndrome virus 1SIRT-1 Sirtuin 1Th1 t-helper lymphocyte type 1Immune systemROS reactive oxygen speciesTGF-β transforming growth factor betaET-1 endothelin-1ComputingMethodologies_COMPUTERGRAPHICSADAM-17 metallopeptidase domain 17business.industrySARS-CoV-2SBP systolic blood pressureCOVID-19HDACs histone deacetylasesComorbidityImmune Systembusiness5-LO lipoxygenase 5Ageing Research Reviews
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Associations of overweight and metabolic health with successful aging: 32-year follow-up of the Helsinki Businessmen Study

2020

Background & aims: Prognostic significance of metabolically healthy overweight and obesity (MHO) is under debate. However the relationship between MHO and health-related quality of life (HRQoL) is less studied. We compared successful aging (longevity plus HRQoL) in men with MHO, metabolically healthy normal weight (MHN) and metabolically unhealthy overweight and obesity (MUO). Methods: In the Helsinki Businessmen Study longitudinal cohort, consisting of men born 1919 to 1934. In 1985/86, overweight (BMI >= 25 kg/m(2)) and metabolic health were determined in 1309 men (median age 60 years). HRQoL was assessed using RAND-36/SF-36 in 2000 and 2007, and all-cause mortality retrieved from registe…

Male0301 basic medicineAgingFITNESSIMPACTRAND-36Successful agingMetabolically healthy overweight and obesityelämänlaatuOverweightCritical Care and Intensive Care MedicineOLD-AGE0302 clinical medicineQuality of lifeQUALITY-OF-LIFEaineenvaihduntaFinlandRISKNutrition and DieteticsHazard ratioylipainoMiddle Aged3. Good healthCARDIOVASCULAR-DISEASEOBESITY3143 Nutritionmedicine.symptomQuality of lifemedicine.medical_specialty030209 endocrinology & metabolism03 medical and health sciencesInternal medicinemedicineHumansAged030109 nutrition & dieteticsMetabolically unhealthy overweight and obesitySuccessful agingbusiness.industryMORTALITYOdds ratioOverweightmedicine.diseaseObesityConfidence intervalBODY-MASS INDEXikääntyminenPHYSICAL-ACTIVITYNonagenariansbusinessBody mass indexFollow-Up StudiesClinical Nutrition
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Structure of self-rated health among the oldest old: Analyses in the total population and those living with dementia

2020

No previous study has explored the structure of self-rated health (SRH), a measure holding strong predictive value for future health events, in the oldest old or in individuals with dementia. The aim was to construct a structural equation model of SRH for oldest old in general and for oldest old with dementia, and to explore direct and indirect associations between health-related factors and SRH. Cross-sectional data from the Vitality 90+, a population-based study in the city of Tampere, Finland, was used. Data were gathered by a mailed questionnaire in 2014. Altogether 1299 nonagenarians, of which 408 had self-reported dementia or cognitive decline, were included. Structural equation model…

cognitionkognitioeducationstructural equation modellingperceived healthSelf-assessed healthkoettu terveysArticleCognitionlcsh:Social sciences (General)FinlandPerceived healthlcsh:Public aspects of medicinelcsh:RA1-1270self-assessed health3142 Public health care science environmental and occupational health3141 Health care sciencebody regions5142 Social policynonagenariansStructural equation modellingNonagenarianslcsh:H1-99316 NursingmuistisairaatikääntyneetSSM - Population Health
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